Carbapenem-resistant Enterobacteriaceae: A review of treatment and outcomes
TLDR
In summary, new antibiotics are greatly needed, as is additional prospective research for combination therapy over single-agent therapy for the treatment of CRE bloodstream infections.About:
This article is published in Diagnostic Microbiology and Infectious Disease.The article was published on 2013-02-01 and is currently open access. It has received 288 citations till now. The article focuses on the topics: Carbapenem-resistant enterobacteriaceae & Tigecycline.read more
Citations
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Journal ArticleDOI
The global epidemiology of carbapenemase-producing Enterobacteriaceae
David van Duin,Yohei Doi +1 more
TL;DR: Carbapenemase-producing Enterobacteriaceae have been most commonly associated with the Indian Subcontinent as well as with specific countries in Europe, including Romania, Denmark, Spain, and Hungary.
Journal ArticleDOI
Colistin Versus Ceftazidime-Avibactam in the Treatment of Infections Due to Carbapenem-Resistant Enterobacteriaceae
David van Duin,Judith J. Lok,Michelle Earley,Eric Cober,Sandra S. Richter,Federico Perez,Federico Perez,Robert A. Salata,Robert C. Kalayjian,Richard R. Watkins,Richard R. Watkins,Yohei Doi,Keith S Kaye,Vance G. Fowler,David L. Paterson,Robert A. Bonomo,Robert A. Bonomo,Scott R. Evans +17 more
TL;DR: Ceftazidime-avibactam may be a reasonable alternative to colistin in the treatment of K. pneumoniae carbapenemase-producing CRE infections and require confirmation in a randomized controlled trial.
Journal ArticleDOI
Ceftazidime/Avibactam and Ceftolozane/Tazobactam: Second-generation β-Lactam/β-Lactamase Inhibitor Combinations.
David van Duin,Robert A. Bonomo +1 more
TL;DR: Ceftolozane/tazobactam and ceftazidime/avibactam are 2 new second-generation cephalosporin/β-lactamase inhibitor combinations and may prove useful in the treatment of MDR GNB infections.
Journal ArticleDOI
Epidemiology and Diagnostics of Carbapenem Resistance in Gram-negative Bacteria.
TL;DR: Advances in rapid diagnostic tests to improve the detection of carbapenem resistance and the use of large, population-based datasets to capture a greater proportion of carbAPenem-resistant organisms can help to gain a better understanding of this urgent threat and enable physicians to select the most appropriate antibiotics.
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Multidrug-Resistant Bacteria in the Community: Trends and Lessons Learned
David van Duin,David L. Paterson +1 more
TL;DR: Prevention of further community spread of MDR bacteria is of the utmost importance, and requires a multidisciplinary approach involving all stakeholders.
References
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Colistin: The Revival of Polymyxins for the Management of Multidrug-Resistant Gram-Negative Bacterial Infections
TL;DR: Recent studies of patients who received intravenous polymyxins for the treatment of serious P. aeruginosa and Acinetobacter baumannii infections of various types, including pneumonia, bacteremia, and urinary tract infections, have led to the conclusion that these antibiotics have acceptable effectiveness and considerably less toxicity than was reported in old studies.
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Clinical Response to Aminoglycoside Therapy: Importance of the Ratio of Peak Concentration to Minimal Inhibitory Concentration
TL;DR: It is demonstrated that a high peak concentration relative to the MIC for the infecting organism is a major determinant of the clinical response to aminoglycoside therapy.
Journal ArticleDOI
Health care costs and mortality associated with nosocomial diarrhea due to Clostridium difficile.
TL;DR: A conservative estimate of the cost of this disease in the United States exceeds $1.1 billion per year after adjustment for age, comorbidity, and disease severity.
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Predictors of mortality in bloodstream infections caused by Klebsiella pneumoniae carbapenemase-producing K. pneumoniae: importance of combination therapy
Mario Tumbarello,Pierluigi Viale,Claudio Viscoli,Enrico Maria Trecarichi,Fabio Tumietto,Anna Marchese,Teresa Spanu,Simone Ambretti,Francesca Ginocchio,Francesco Cristini,Angela Raffaella Losito,Sara K. Tedeschi,Roberto Cauda,Matteo Bassetti,Matteo Bassetti +14 more
TL;DR: To improve survival, combined treatment with 2 or more drugs with in vitro activity against the isolate, especially those also including a carbapenem, may be more effective than active monotherapy.
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Combating antimicrobial resistance: policy recommendations to save lives.
Brad Spellberg,Martin J. Blaser,Robert Guidos,Helen W. Boucher,John S. Bradley,Barry I. Eisenstein,Dale N. Gerding,Ruth Lynfield,L B Reller,John H. Rex,Schwartz D,Edward Septimus,Fred C. Tenover,David N. Gilbert +13 more
TL;DR: This policy paper summarizes the Infectious Diseases Society of America’s (IDSA) recommendations about how best to address the synergistic crises of rising rates of antibiotic resistance and waning approvals of new antibiotics.
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