Journal ArticleDOI
Carbon catabolite repression in bacteria: many ways to make the most out of nutrients
Boris Görke,Jörg Stülke +1 more
TLDR
The most recent findings on the different mechanisms that have evolved to allow bacteria to use carbon sources in a hierarchical manner are discussed.Abstract:
Using the process of carbon catabolite repression (CCR), bacteria control gene expression and protein activity to preferentially metabolize the carbon sources that are most easily accessible and allow fastest growth. Recent findings have provided new insight into the mechanisms that different bacteria use to control CCR. Most bacteria can selectively use substrates from a mixture of different carbon sources. The presence of preferred carbon sources prevents the expression, and often also the activity, of catabolic systems that enable the use of secondary substrates. This regulation, called carbon catabolite repression (CCR), can be achieved by different regulatory mechanisms, including transcription activation and repression and control of translation by an RNA-binding protein, in different bacteria. Moreover, CCR regulates the expression of virulence factors in many pathogenic bacteria. In this Review, we discuss the most recent findings on the different mechanisms that have evolved to allow bacteria to use carbon sources in a hierarchical manner.read more
Citations
More filters
Journal ArticleDOI
Functional diversity within the simple gut microbiota of the honey bee
TL;DR: The sequenced metagenome of the gut microbiota of honey bees reveals insights into mutualistic functions governed by the microbiota of this important pollinator and indicates that the honey bee can serve as a model for understanding more complex gut-associated microbial communities.
Journal ArticleDOI
Nitroaromatic Compounds, from Synthesis to Biodegradation
Kou San Ju,Rebecca E. Parales +1 more
TL;DR: This review provides an overview of the synthesis of both man-made and biogenic nitroaromatic compounds, the bacteria that have been identified to grow on and completely mineralize nitrobiotic compounds, and the pathways that are present in these strains.
Journal ArticleDOI
Degradation of alkanes by bacteria
TL;DR: This review summarizes current knowledge on how microorganisms degrade alkanes, focusing on the biochemical pathways used and on how the expression of pathway genes is regulated and integrated within cell physiology.
Journal ArticleDOI
Listeria monocytogenes - from saprophyte to intracellular pathogen.
TL;DR: The regulation of PrfA and its role in the L. monocytogenes transition from the saprophytic stage to the virulent intracellular stage is described.
Journal ArticleDOI
Carbon catabolite repression in Pseudomonas : optimizing metabolic versatility and interactions with the environment
TL;DR: This review summarizes the regulatory mechanisms responsible for CCR in the bacteria of the genus Pseudomonas, which can live in many different habitats and has implications in the optimization of biotechnological processes such as biotransformations or bioremediation strategies.
References
More filters
Journal ArticleDOI
Network motifs in the transcriptional regulation network of Escherichia coli
TL;DR: This work applied new algorithms for systematically detecting network motifs to one of the best-characterized regulation networks, that of direct transcriptional interactions in Escherichia coli, and finds that much of the network is composed of repeated appearances of three highly significant motifs.
Journal ArticleDOI
Phosphoenolpyruvate:carbohydrate phosphotransferase systems of bacteria.
TL;DR: The IIAGlc protein, part of the glucose-specific PTS, is a central regulatory protein which in its nonphosphorylated form can bind to and inhibit several non-PTS uptake systems and thus prevent entry of inducers.
Journal ArticleDOI
How Phosphotransferase System-Related Protein Phosphorylation Regulates Carbohydrate Metabolism in Bacteria
TL;DR: The known protein phosphorylation-related regulatory functions of the PTS are summarized, which shows that the PTS regulation network not only controls carbohydrate uptake and metabolism but also interferes with the utilization of nitrogen and phosphorus and the virulence of certain pathogens.
Journal ArticleDOI
Genomic islands in pathogenic and environmental microorganisms
TL;DR: Recent lessons that have been learned from pathogenicity islands in pathogenic microorganisms are discussed and how they apply to the role of genomic islands in commensal, symbiotic and environmental bacteria are discussed.