Journal ArticleDOI
Carbonylative Heck reactions using CO generated ex situ in a two-chamber system.
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TLDR
Application to isotope labeling, incorporating (13)CO, was further established and an effective exploitation of the hazardous CO gas is obtained affording chalcone derivatives in good yields.About:
This article is published in Organic Letters.The article was published on 2011-04-06. It has received 91 citations till now. The article focuses on the topics: Heck reaction & Carbon monoxide.read more
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Chalcone: A Privileged Structure in Medicinal Chemistry.
TL;DR: This review aims to highlight the recent evidence of chalcone as a privileged scaffold in medicinal chemistry and is expected to be a comprehensive, authoritative, and critical review of the chal cone template to the chemistry community.
Journal ArticleDOI
The Development and Application of Two-Chamber Reactors and Carbon Monoxide Precursors for Safe Carbonylation Reactions
TL;DR: A two-chamber reactor (COware) is designed and developed for the controlled delivery and utilization of stoichiometric amounts of CO for Pd-catalyzed carbonylation reactions and carbon isotope variants of the CO precursors provide a simple means for performing isotope-labeling syntheses.
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Silacarboxylic acids as efficient carbon monoxide releasing molecules: synthesis and application in palladium-catalyzed carbonylation reactions.
TL;DR: The release of CO from crystalline MePh( 2)SiCO(2)H proved to be highly efficient, and it was successfully applied in a selection of palladium-catalyzed carbonylative couplings using near-stoichiometric quantities of carbon monoxide precursor.
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Recent advances in the transition metal catalyzed carbonylation of alkynes, arenes and aryl halides using CO surrogates
TL;DR: A review of the progress in the past decade in the development of synthetic methodologies in which carbonylation reactions are carried out without the use of gaseous carbon monoxide or using CO surrogates can be found in this article.
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Journal ArticleDOI
Palladium-catalyzed vinylic hydrogen substitution reactions with aryl, benzyl, and styryl halides
Richard F. Heck,J. P. Nolley +1 more
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Palladium-catalyzed carbonylation reactions of aryl halides and related compounds.
TL;DR: The recent academic developments in palladium-catalyzed carbonylation reactions of aromatic halides in the presence of various nucleophiles are summarized and the first industrial processes are summarized.
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Arylation of Olefin with Aryl Iodide Catalyzed by Palladium
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A versatile catalyst for Heck reactions of aryl chlorides and aryl bromides under mild conditions.
Adam F. Littke,Gregory C. Fu +1 more
TL;DR: In the presence of Cy2NMe, Pd/P(t-Bu)3 serves as an exceptionally mild and versatile catalyst for Heck reactions of aryl chlorides and bromides, representing an advance over previously reported catalysts for these Heck coupling processes.