Cardiac fibrosis - A short review of causes and therapeutic strategies.
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TLDR
This review presents an overview of what is known about cardiac fibrosis including the role of cardiac cells and extracellular matrix in this disease, and summarizes current diagnostic tools and highlights pre-clinical or clinical therapeutic strategies to address this disease.About:
This article is published in Advanced Drug Delivery Reviews.The article was published on 2019-05-31 and is currently open access. It has received 232 citations till now. The article focuses on the topics: Cardiac fibrosis & Fibrosis.read more
Citations
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Drug delivery to macrophages: A review of targeting drugs and drug carriers to macrophages for inflammatory diseases
Wei He,Wei He,Wei He,Neha Kapate,Neha Kapate,Neha Kapate,C. Wyatt Shields,C. Wyatt Shields,Samir Mitragotri,Samir Mitragotri +9 more
TL;DR: The role of Macrophages in the initiation and progression of various inflammatory diseases is discussed, the leading drugs used to regulate macrophages are summarized, and drug delivery systems designed to target macrophage are reviewed.
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Small-molecule fluorescence-based probes for interrogating major organ diseases.
Hai Hao Han,He Tian,Yi Zang,Adam C. Sedgwick,Jia Li,Jonathan L. Sessler,Xiao-Peng He,Tony D. James,Tony D. James +8 more
TL;DR: A tutorial review of the development of small-molecule fluorescent probes that allow the targeting of organ related processes in vitro and in vivo can be found in this article, where the authors highlight the design strategy that underlies the preparation of various promising probes, their optical response to key biomarkers, and proof-of-concept biological studies.
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The role of extracellular matrix in biomechanics and its impact on bioengineering of cells and 3D tissues.
TL;DR: The cells and tissues of the human body are constantly exposed to exogenous and endogenous forces that are referred to as biomechanical cues, and these processes are highly relevant for disease modelling or when aiming for the development of novel therapies.
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3D bioprinting of mechanically tuned bioinks derived from cardiac decellularized extracellular matrix.
Yu Jung Shin,Ryan T. Shafranek,Jonathan H. Tsui,Jelisha Walcott,Alshakim Nelson,Deok Ho Kim,Deok Ho Kim,Deok Ho Kim +7 more
TL;DR: Hydrogel bioinks derived from decellularized extracellular matrix combine extrudability, shape fidelity, rapid cross-linking, and cytocompatibility in a single formulation, highlighting the potential for applications in modeling both healthy and fibrotic cardiac tissue.
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Naringenin and naringin in cardiovascular disease prevention: A preclinical review
Reza Heidary Moghaddam,Zeinab Samimi,Seyed Zachariah Moradi,Peter J. Little,Suowen Xu,Mohammad Hosein Farzaei +5 more
TL;DR: The data collected in this review may serve as a comprehensive reference for the effects of naringin, and naringenin in cardiovascular disease, which may be beneficial for further research and for the design of naredin and naredenin analogs as new therapeutic options for cardiovascular diseases.
References
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Heart Disease and Stroke Statistics—2016 Update: A Report From the American Heart Association
Dariush Mozaffarian,Emelia J. Benjamin,Alan S. Go,Donna K. Arnett,Michael J. Blaha,Mary Cushman,Sandeep R Das,Sarah D. de Ferranti,Jean-Pierre Després,Heather J. Fullerton,Virginia J. Howard,Mark D. Huffman,Carmen R. Isasi,Monik C. Jiménez,Suzanne E. Judd,Brett M. Kissela,Judith H. Lichtman,Lynda D. Lisabeth,Simin Liu,Rachel H. Mackey,David J. Magid,Darren K. McGuire,Emile R. Mohler,Claudia S. Moy,Paul Muntner,Michael E. Mussolino,Khurram Nasir,Robert W. Neumar,Graham Nichol,Latha Palaniappan,Dilip K. Pandey,Mathew J. Reeves,Carlos J. Rodriguez,Wayne D. Rosamond,Paul D. Sorlie,Joel M. Stein,Amytis Towfighi,Tanya N. Turan,Salim S. Virani,Daniel Woo,Robert W. Yeh,Melanie B. Turner +41 more
TL;DR: Author(s): Writing Group Members; Mozaffarian, Dariush; Benjamin, Emelia J; Go, Alan S; Arnett, Donna K; Blaha, Michael J; Cushman, Mary; Das, Sandeep R; de Ferranti, Sarah; Despres, Jean-Pierre; Fullerton, Heather J; Howard, Virginia J; Huffman, Mark D; Isasi, Carmen R; Jimenez, Monik C; Judd, Suzanne
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The extracellular matrix at a glance
TL;DR: The extracellular matrix is the non-cellular component present within all tissues and organs, and provides not only essential physical scaffolding for the cellular constituents but also initiates crucial biochemical and biomechanical cues that are required for tissue development.
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Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts.
TL;DR: It is shown that the subcutaneous administration of transforming growth factor- beta 1 to rats results in the formation of a granulation tissue in which alpha-SM actin expressing myofibroblasts are particularly abundant, suggesting that TGF beta 1 plays an important role in my ofibroblast differentiation during wound healing and fibrocontractive diseases by regulating the expression of alpha- SM actin in these cells.
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Formation and Function of the Myofibroblast during Tissue Repair
TL;DR: Intervention with myofibroblast stress perception and transmission offers novel strategies to reduce tissue contracture; stress release leads to the instant loss of contraction and promotes apoptosis.
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The pathogenesis of cardiac fibrosis
TL;DR: Both experimental and clinical evidence suggests that cardiac fibrotic alterations may be reversible, and understanding the mechanisms responsible for initiation, progression, and resolution of cardiac fibrosis is crucial to design anti-fibrotic treatment strategies for patients with heart disease.