Journal ArticleDOI
Cardiovascular disease risk in women with pre-eclampsia: systematic review and meta-analysis
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TLDR
Women diagnosed with pre-eclampsia are at increased risk of future cardiovascular or cerebrovascular events, with an estimated doubling of odds compared to unaffected women, and this has implications for the follow-up of all women who experience pre- eClampsia, not just those who deliver pre-term.Abstract:
There is increasing evidence that pre-eclampsia, a principal cause of maternal morbidity, may also be a risk factor for future cardiovascular and cerebrovascular events. This review aimed to assess the current evidence and quantify the risks of cardiovascular disease (CVD), cerebrovascular events and hypertension associated with prior diagnosis of pre-eclampsia. Medline and Embase were searched with no language restrictions, as were core journals and reference lists from reviews up until January 2012. Case–control and cohort studies which reported cardiovascular and cerebrovascular diseases or hypertension diagnosed more than 6 weeks postpartum, in women who had a history of pre-eclampsia relative to women who had unaffected pregnancies, were included. Fifty articles were included in the systematic review and 43 in the meta-analysis. Women with a history of pre-eclampsia or eclampsia were at significantly increased odds of fatal or diagnosed CVD [odds ratio (OR) = 2.28, 95 % confidence interval (CI): 1.87, 2.78], cerebrovascular disease (OR = 1.76, 95 % CI 1.43, 2.21) and hypertension [relative risk (RR) = 3.13, 95 % CI 2.51, 3.89]. Among pre-eclamptic women, pre-term delivery was not associated with an increased risk of a future cardiovascular event (RR = 1.32, 95 % CI 0.79, 2.22). Women diagnosed with pre-eclampsia are at increased risk of future cardiovascular or cerebrovascular events, with an estimated doubling of odds compared to unaffected women. This has implications for the follow-up of all women who experience pre-eclampsia, not just those who deliver pre-term. This association may reflect shared common risk factors for both pre-eclampsia and cardiovascular and cerebrovascular disease.read more
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Journal ArticleDOI
Preeclampsia: Pathophysiology, Challenges, and Perspectives
Sarosh Rana,Elizabeth R. Lemoine,Elizabeth R. Lemoine,Joey P. Granger,S. Ananth Karumanchi,S. Ananth Karumanchi +5 more
TL;DR: The current evidence for the role of abnormal placentation and therole of placental factors such as the antiangiogenic factor, sFLT1 (soluble fms-like tyrosine kinase 1) in the pathogenesis of the maternal syndrome of preeclampsia is discussed.
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Guidelines for the Prevention of Stroke in Women A Statement for Healthcare Professionals From the American Heart Association/American Stroke Association
Cheryl Bushnell,Louise D. McCullough,Issam A. Awad,Monique V. Chireau,Wende N. Fedder,Karen L. Furie,Virginia J. Howard,Judith H. Lichtman,Lynda D. Lisabeth,Ileana L. Piña,Mathew J. Reeves,Kathryn M. Rexrode,Gustavo Saposnik,Vineeta Singh,Amytis Towfighi,Viola Vaccarino,Matthew Walters +16 more
TL;DR: This guideline focuses on the risk factors unique to women, such as reproductive factors, and those that are more common in women, including migraine with aura, obesity, metabolic syndrome, and atrial fibrillation, which believe a female-specific stroke risk score is warranted.
Journal ArticleDOI
Preeclampsia and Future Cardiovascular Health: A Systematic Review and Meta-Analysis.
Pensee Wu,Randula Haththotuwa,Chun Shing Kwok,Aswin Babu,Rafail A. Kotronias,Claire A Rushton,Azfar Zaman,Anthony A. Fryer,Umesh T. Kadam,Carolyn Chew-Graham,Mamas A. Mamas +10 more
TL;DR: Preeclampsia is associated with a 4-fold increase in future incident heart failure and a 2-fold increased risk in coronary heart disease, stroke, and death because of coronary heart or cardiovascular disease.
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Cohort Profile Update: The Norwegian Mother and Child Cohort Study (MoBa)
Per Magnus,Charlotte Birke,Kristine Vejrup,Anita Haugan,Elin R. Alsaker,Anne Kjersti Daltveit,Marte Handal,Margaretha Haugen,Gudrun Høiseth,Gun Peggy Knudsen,Liv Paltiel,Patricia Schreuder,Kristian Tambs,Line Vold,Camilla Stoltenberg +14 more
TL;DR: The purpose of this update is to explain and describe new additions to the data collection, including questionnaires at 5, 7, 8 and 13 years as well as linkages to health registries, and to point to some findings and new areas of research.
Journal ArticleDOI
Sex differences in Alzheimer disease — the gateway to precision medicine
Maria Teresa Ferretti,Maria Florencia Iulita,Enrica Cavedo,Patrizia A. Chiesa,Annemarie Schumacher Dimech,Antonella Santuccione Chadha,Francesca Baracchi,Hélène Girouard,Sabina Misoch,Ezio Giacobini,Herman Depypere,Harald Hampel +11 more
TL;DR: The cumulative evidence reviewed indicates sex-specific patterns of disease manifestation as well as sex differences in the rates of cognitive decline and brain atrophy, suggesting that sex is a crucial variable in disease heterogeneity.
References
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Book
Systematic Reviews in Health Care : Meta-Analysis in Context
TL;DR: The second edition of this best-selling book has been thoroughly revised and expanded to reflect the significant changes and advances made in systematic reviewing.
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