John Varigos

TL;DR: Abnormal lipids, smoking, hypertension, diabetes, abdominal obesity, psychosocial factors, consumption of fruits, vegetables, and alcohol, and regular physical activity account for most of the risk of myocardial infarction worldwide in both sexes and at all ages in all regions.

TL;DR: Clopidogrel plus ASA plus irbesartan will lead to a new understanding of the role of combined antiplatelet therapy and therole of blood pressure lowering with an angiotensin II receptor blocker in patients with AF.

TL;DR: An individual participant data meta-analysis of all recorded adverse muscle events in large, long-term, randomised, double-blind trials of statin therapy found a small, clinically insignificant increase in median creatine kinase values of approximately 0·02 times the upper limit of normal.

TL;DR: In patients with chronic coronary artery disease and/or peripheral artery disease (PAD), extended combination treatment for a median of 1 year and a maximum of 3 years was associated with incidence rates for efficacy and bleeding that were similar to or lower than those seen during the randomized treatment phase, without any new safety signals as mentioned in this paper .

TL;DR: In this article, the authors showed that cholesterol and blood pressure can be effectively and safely lowered with statin drugs and BP-lowering drugs, reducing major cardiovascular events by 20%-30% within 5 years in high-risk individuals.