Cardiovascular Risk in Women With PCOS
Pietro Scicchitano,Ilaria Dentamaro,Rosa Carbonara,Gabriella Bulzis,Annamaria Dachille,Paola Caputo,Roberta Riccardi,Manuela Locorotondo,Cosimo Mandurino,Marco Matteo Ciccone +9 more
Reads0
Chats0
TLDR
The main connections between PCOS and cardiovascular risk factors are pointed out according to the latest findings coming from literature data analysis, and the great influences that such a common disease can have on the patients’ health integrity are depicted.Abstract:
Polycystic ovary syndrome (PCOS), or Stein-Leventhal syndrome, is a common endocrine disorder defined by two of the three following features: i) oligoovulation or anovulation, ii) clinical and/or biochemical signs of hyperandrogenism, or iii) polycystic ovaries, once the related endocrinological and gynaecological disorders have been excluded. PCOS does not exclusively involve the reproductive apparatus , it has a complex number of systemic relevancy symptoms. It leads to Metabolic Syndrome, with severe consequences on the cardiovascular apparatus. Many clinical studies have underlined the connection between PCOS and the cardiovascular risk profile of such female patients, due to a lipid/glucose altered metabolism, hypertension, systemic inflammatory condition (assessable by markers such as VES, TNF-alfa, citokines and C-reactive protein (hsPCR) levels), and vascular injuries. Considering the early onset of the disease, PCOS could be considered as a real cardiovascular risk factor which affects the quality of life seriously. The current review aimed to point out the main connections between PCOS and cardiovascular risk factors according to the latest findings coming from literature data analysis, and try to depict the great influences that such a common disease can have on the patients' health integrity.read more
Citations
More filters
Journal ArticleDOI
Complications and challenges associated with polycystic ovary syndrome: current perspectives.
TL;DR: Women with PCOS are considered to be at increased risk of obstetric, cardiometabolic, oncology, and psychological complications throughout life, and it is recommended that these women be accurately assessed with periodic follow-up.
Journal ArticleDOI
Metformin reduces arterial stiffness and improves endothelial function in young women with polycystic ovary syndrome:a randomized, placebo-controlled, crossover trial
Neera Agarwal,Sam P. L. Rice,Hemanth Bolusani,Stephen D. Luzio,Gareth Dunseath,Marian Ludgate,D. Aled Rees +6 more
TL;DR: In this paper, the effects of short-term metformin therapy on arterial stiffness and endothelial function in women with polycystic ovarian syndrome (PCOS) were investigated.
Journal ArticleDOI
Selenium Supplementation and the Effects on Reproductive Outcomes, Biomarkers of Inflammation, and Oxidative Stress in Women with Polycystic Ovary Syndrome.
Maryam Razavi,Mehri Jamilian,Z. Fakhrieh Kashan,Zahra Heidar,Mehran Mohseni,Yaser Ghandi,Tayebeh Bagherian,Zatollah Asemi +7 more
TL;DR: Taken together, selenium supplementation for 8 weeks among PCOS women had beneficial effects on reproductive outcomes, DHEA, hs-CRP, and MDA levels.
Journal ArticleDOI
Effects of Zinc Supplementation on Endocrine Outcomes in Women with Polycystic Ovary Syndrome: a Randomized, Double-Blind, Placebo-Controlled Trial
Mehri Jamilian,Fatemeh Foroozanfard,Fereshteh Bahmani,Rezvan Talaee,Mahshid Monavari,Zatollah Asemi +5 more
TL;DR: Using 50 mg/day elemental zinc for 8 weeks among PCOS women had beneficial effects on alopecia, hirsutism, and plasma MDA levels; however, it did not affect hormonal profiles, inflammatory cytokines, and other biomarkers of oxidative stress.
Journal ArticleDOI
Association Study between Polycystic Ovarian Syndrome and the Susceptibility Genes Polymorphisms in Hui Chinese Women
TL;DR: The present study suggested that the SNP rs13405728 in the LHCGR gene was associated with PCOS in Hui ethnic women, and its TT genotype characterized with higher level of TT, TG and LDL.
References
More filters
Journal ArticleDOI
Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome
TL;DR: Since the 1990 NIH-sponsored conference on polycystic ovary syndrome, it has become appreciated that the syndrome encompasses a broader spectrum of signs and symptoms of ovarian dysfunction than those defined by the original diagnostic criteria.
Journal ArticleDOI
Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis.
TL;DR: Since PCOS usually has a menarchal age of onset, this makes it a particularly appropriate disorder in which to examine the ontogeny of defects in carbohydrate metabolism and for ascertaining large three-generation kindreds for positional cloning studies to identify NIDDM genes.
Journal ArticleDOI
Clinical Application of C-Reactive Protein for Cardiovascular Disease Detection and Prevention
TL;DR: The addition of CRP to standard cholesterol evaluation may provide a simple and inexpensive method to improve global risk prediction and compliance with preventive approaches.
Journal ArticleDOI
Hyperhomocysteinemia: an independent risk factor for vascular disease.
Robert Clarke,Leslie Daly,Killian Robinson,E. R. Naughten,Seamus F. Cahalane,Brian Fowler,Ian D. Graham +6 more
TL;DR: Hyperhomocysteinemia is an independent risk factor for vascular disease, including coronary disease, and in most instances is probably due to cystathionine beta-synthase deficiency.
Journal ArticleDOI
Mechanisms, Pathophysiology, and Therapy of Arterial Stiffness
TL;DR: A number of lifestyle changes and therapies that reduce arterial stiffness are presented, including weight loss, exercise, salt reduction, alcohol consumption, and neuroendocrine-directed therapies, such as those targeting the renin-angiotensin aldosterone system, natriuretic peptides, insulin modulators, as well as novel therapies that target advanced glycation end products.
Related Papers (5)
Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome
Cardiometabolic aspects of polycystic ovarian syndrome.
Consensus on women's health aspects of polycystic ovary syndrome (PCOS): The Amsterdam ESHRE/ASRM-Sponsored 3rd PCOS Consensus Workshop Group
Bart C.J.M. Fauser,Basil C. Tarlatzis,Robert W. Rebar,Richard S. Legro,Adam H. Balen,Roger A. Lobo,Enrico Carmina,Jeffrey P. Chang,Bulent O. Yildiz,Joop S.E. Laven,Jacky Boivin,Felice Petraglia,C. N. Wijeyeratne,Robert J. Norman,Andrea Dunaif,Stephen Franks,Robert A. Wild,Daniel A. Dumesic,Kurt T. Barnhart +18 more