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Cd4
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This article is published in International Journal of Dermatology and Venereology.The article was published on 1990-05-15 and is currently open access. It has received 146 citations till now.read more
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Regulatory CD4+CD25+ T Cells in Tumors from Patients with Early-Stage Non-Small Cell Lung Cancer and Late-Stage Ovarian Cancer
Edward Y. Woo,Christina S. Chu,Theresa J. Goletz,Katia Schlienger,Heidi Yeh,George Coukos,Stephen C. Rubin,Larry R. Kaiser,Carl H. June +8 more
TL;DR: T tumor-associated T cells from patients with early and late-stage epithelial tumors contain increased proportions of CD4(+)CD25(+) T cells that secrete the immunosuppressive cytokine transforming growth factor-beta, consistent with the phenotype of regulatory T cells.
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Human CD4(+)CD25(+) cells: a naturally occurring population of regulatory T cells.
Wan-Fai Ng,Phillip J. Duggan,Frederique Ponchel,Giuseppe Matarese,Giovanna Lombardi,A. David Edwards,John D. Isaacs,Robert I. Lechler +7 more
TL;DR: The results suggest that CD4(+)CD25(+) cells represent a population of regulatory T cells that arise during fetal life and may play a key role in the prevention of autoimmune diseases in humans.
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Mechanisms of action of probiotics: Recent advances
TL;DR: Mechanisms contributing to altered immune function in vivo induced by probiotic bacteria may include modulation of the microbiota itself, improved barrier function with consequent reduction in immune exposure to microbiota, and direct effects of bacteria on different epithelial and immune cell types.
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The CCR5 and CXCR4 coreceptors--central to understanding the transmission and pathogenesis of human immunodeficiency virus type 1 infection.
TL;DR: This review will discuss what is known, what is suspected, and what still remains obscure about the central role played by coreceptor expression and usage in the transmission and pathogenic consequences of human immunodeficiency virus type 1 (HIV-1) infection.
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Estimating the proportion of treatment effect explained by a surrogate marker
TL;DR: The extent to which a biological marker is a surrogate endpoint for a clinical event by the proportional reduction in the regression coefficient for the treatment indicator due to the inclusion of the marker in the Cox regression model is measured.
References
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The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus
Angus Dalgleish,Peter C. L. Beverley,Paul R. Clapham,Dorothy H. Crawford,Mel Greaves,Robin A. Weiss +5 more
TL;DR: It is concluded that the CD4 antigen is an essential and specific component of the receptor for the causative agent of AIDS.
Journal Article
Regulatory CD4+CD25+ T Cells in Tumors from Patients with Early-Stage Non-Small Cell Lung Cancer and Late-Stage Ovarian Cancer
Edward Y. Woo,Christina S. Chu,Theresa J. Goletz,Katia Schlienger,Heidi Yeh,George Coukos,Stephen C. Rubin,Larry R. Kaiser,Carl H. June +8 more
TL;DR: T tumor-associated T cells from patients with early and late-stage epithelial tumors contain increased proportions of CD4(+)CD25(+) T cells that secrete the immunosuppressive cytokine transforming growth factor-beta, consistent with the phenotype of regulatory T cells.
Journal ArticleDOI
Transforming Growth Factor-β
TL;DR: Transforming growth factor-β (TGF-β) as mentioned in this paper is the cytokine with the broadest range of activities in repair of injured tissue, based both on the variety of cell types that produce and/or respond to it and on the spectrum of its cellular responses.
Journal ArticleDOI
Evolutionary conservation of surface molecules that distinguish T lymphocyte helper/inducer and cytotoxic/suppressor subpopulations in mouse and man
Jeffrey A. Ledbetter,RL Evans,M Lipinski,C Cummingham-Rundles,R.A. Good,Leonard A. Herzenberg +5 more
TL;DR: The maintenance of the homologous molecules on functionally distinct T cell subpopulations in two evolutionarily distant species suggests that the Lyt and Leu antigens perform essential functions for the cells on which they are found.
Journal ArticleDOI
Normal development and function of CD8+ cells but markedly decreased helper cell activity in mice lacking CD4.
Amin Rahemtulla,Wai-Ping Fung-Leung,Marco W. Schilham,Thomas M. Kündig,S. R. Sambhara,Aru Narendran,A. Arabian,Andrew Wakeham,Christopher J. Paige,R. M. Zinkernagel,Richard G. Miller,T. W. Mak +11 more
TL;DR: In these mice, the development of CD8+ T cells and myeloid components is unaltered, indicating that expression of CD4 on progenitor cells and CD4+CD8+ (double positive) thymocytes is not obligatory, which is important to the understanding of immune disorders, including AIDS.