Cellular immunity in vaccinia infection of mice. Anti-thymocyte serum effects on primary and secondary responsiveness.
TLDR
Rabbit anti-mouse thymocyte serum suppressed host cell-mediated responsiveness to intravenously administered vaccinia virus, thereby augmenting the morbidity and mortality of this infection.Abstract:
Rabbit anti-mouse thymocyte serum suppressed host cell-mediated responsiveness to intravenously administered vaccinia virus, thereby augmenting the morbidity and mortality of this infection. It did not affect either humoral antibody or interferon production in response to vaccinia virus. No effects were noted on primary or secondary immunity to intracerebral virus inoculation.read more
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Molecular Mechanisms of Lymphocyte-Mediated Cytotoxicity and Their Role in Immunological Protection and Pathogenesis In Vivo
TL;DR: Evidence for a role of Fas-dependent cytotoxicity as a T cell effector mechanism in vivo is lacking, and current data suggest that the main function of Fas may be in regulation of the immune response and apparently less at the level of an effector mechanisms in host defense.
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CD8 is needed for development of cytotoxic T cells but not helper T cells.
Wai-Ping Fung-Leung,Marco W. Schilham,Amin Rahemtulla,Thomas M. Kündig,Maja Vollenweider,Julia Potter,Willem van Ewijk,Tak W. Mak +7 more
TL;DR: It is suggested that CD8 is necessary for the maturation and positive selection of class I MHCrestricted cytotoxic T lymphocytes but is not required on any of the intermediate thymocyte populations during the development of functional class II MHC restricted helper T cells.
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Immunodepression and malignancy.
TL;DR: Both clinical and experimental evidence indicates that the diseases or procedures that lower the immune functions in mammals are associated with a higher incidence of malignancies.
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The roles of perforin- and Fas-dependent cytotoxicity in protection against cytopathic and noncytopathic viruses.
David Kägi,Peter Seiler,Jovan Pavlovic,Birgit Ledermann,Kurt Bürki,Rolf M. Zinkernagel,Hans Hengartner +6 more
TL;DR: It is suggested that perforin‐dependent cytotoxicity mediated by T cells is crucial for protection against noncytopathic viruses, whereas infections with cytopATHic viruses are controlled by nonlytic T cell‐dependent soluble mediators such as cytokines and neutralizing antibodies.
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Resistance to Intracellular Infection
TL;DR: A mechanism of defense in which a specifically committed lymphocyte serves as the immunologic go-between that enables mononuclear phagocytes to perform their microbicidal function is called into play.