Journal ArticleDOI
Cellular tumorigenicity in nude mice: Correlation with cell growth in semi-solid medium
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TLDR
It is suggested that the degree of cell growth in methyl cellulose is a useful parameter in vitro for predicting tumorigenicity in the animal, and the potential usefulness of the nude mouse for analysis of cellular malignancy irrespective of the tissue or species of origin is demonstrated.About:
This article is published in Cell.The article was published on 1974-12-01. It has received 826 citations till now. The article focuses on the topics: Nude mouse & Cell growth.read more
Citations
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sources and effects of ionizing radiation
TL;DR: This annex is aimed at providing a sound basis for conclusions regarding the number of significant radiation accidents that have occurred, the corresponding levels of radiation exposures and numbers of deaths and injuries, and the general trends for various practices, in the context of the Committee's overall evaluations of the levels and effects of exposure to ionizing radiation.
Journal ArticleDOI
Cyclosporine induces cancer progression by a cell-autonomous mechanism
Minoru Hojo,Takashi Morimoto,Mary A. Maluccio,Tomohiko Asano,Kengo Morimoto,Mila Lagman,Toshikazu Shimbo,Manikkam Suthanthiran +7 more
TL;DR: It is suggested that immunosuppressants like cyclosporine can promote cancer progression by a direct cellular effect that is independent of its effect on the host's immune cells, and that cyclospora-induced TGF-β production is involved in this.
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Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5' cap
TL;DR: It is reported here that overexpression of eIF-4E in NIH 3T3 and Rat 2 fibroblasts causes their tumorigenic transformation as determined by three criteria: formation of transformed foci on a monolayer of cells; anchorage-independent growth; and tumour formation in nude mice.
References
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Journal ArticleDOI
The serial cultivation of human diploid cell strains.
Leonard Hayflick,P.S. Moorhead +1 more
TL;DR: A consideration of the cause of the eventual degeneration of these strains leads to the hypothesis that non-cumulative external factors are excluded and that the phenomenon is attributable to intrinsic factors which are expressed as senescence at the cellular level.
Journal ArticleDOI
Quantitative studies of the growth of mouse embryo cells in culture and their development into established lines
George J. Todaro,Howard Green +1 more
TL;DR: Disaggregated mouse embryo cells, grown in monolayers, underwent a progressive decline in growth rate upon successive transfer, the rapidity of the decline depending on the inoculation density, but nearly all cultures developed into established lines within 3 months of culture.
Journal ArticleDOI
Selection of Hybrids from Matings of Fibroblasts in vitro and Their Presumed Recombinants
TL;DR: Evidence can be obtained which suggests that mating may be followed by segregation in mice, and when two clonal lines of mouse fibroblasts are grown together for 4 days, hybrid cells can be detected by selective conditions.
Journal ArticleDOI
Agar suspension culture for the selective assay of cells transformed by polyoma virus.
Ian Macpherson,Luc Montagnier +1 more
Journal ArticleDOI
Polyoma transformation of hamster cell clones--an investigation of genetic factors affecting cell competence.
Ian Macpherson,Michael Stoker +1 more
TL;DR: Polyoma virus induced transformation in four fibroblast clones derived from a culture of baby hamster kidney cells is found to be low, not due to these populations consisting of a mixture of genetically stable insusceptible and susceptible cells.
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Agar suspension culture for the selective assay of cells transformed by polyoma virus.
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