Central corneal thickness considered an index of corneal hydration of the UVB irradiated rabbit cornea as influenced by UVB absorber.
TLDR
It is suggested that actinoquinol/ hyaluronic acid drops might be helpful for the human eye in the defence against photooxidative and other oxidative processes.Abstract:
UVB radiation from sunlight induces an acute corneal inflammation, photokeratitis, accompanied by changes in corneal hydration. We employed a method of ultrasonic pachymetry for daily examination of central corneal thickness as an index of corneal hydration of the rabbit cornea repeatedly irradiated by UVB radiation (312 nm, daily dose of 0.25 J/cm(2) during three or four days) as influenced by UVB absorber (actinoquinol combined with hyaluronic acid) dropped on the ocular surface during irradiation. One day after the third irradiation procedure the animals were sacrificed and corneas examined immuno-histochemically for peroxynitrite formation, a marker of oxidative damage, the antioxidant aldehyde dehydrogenase 3A1 and endothelial nitric oxide synthase, an enzyme generated nitric oxide. Results show that UV absorber combined with hyaluronic acid protected the cornea against UVB-induced changes in corneal thickness and microscopical disturbances to the cornea (both seen after buffered saline application) until the fourth experimental day. These UVB doses are equivalent to a daily exposure of 2.5 hrs of the human cornea to solar UVB radiation for three consecutive days. It is suggested that actinoquinol/ hyaluronic acid drops might be helpful for the human eye in the defence against photooxidative and other oxidative processes.read more
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A New Nanosecond UV Laser at 355 nm: Early Results of Corneal Flap Cutting in a Rabbit Model
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Molecular Hydrogen Effectively Heals Alkali-Injured Cornea via Suppression of Oxidative Stress
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Mitochondria-targeted antioxidant SKQ1 protects cornea from oxidative damage induced by ultraviolet irradiation and mechanical injury
Evgeni Yu. Zernii,Evgeni Yu. Zernii,O. S. Gancharova,O. S. Gancharova,Veronika V. Tiulina,Andrey A. Zamyatnin,Andrey A. Zamyatnin,Pavel P. Philippov,Viktoriia E. Baksheeva,Ivan I. Senin +9 more
TL;DR: SkQ1 efficiently prevents UV-induced corneal damage and enhancesCorneal wound healing after UV and mechanical impacts common to ocular surgery.
References
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Journal ArticleDOI
Changes in biologically active ultraviolet radiation reaching the Earth's surface
TL;DR: It will be several years before the beginning of an ozone recovery can be unambiguously identified at individual locations, and future changes in greenhouse gases will affect the future evolution of ozone through chemical, radiative, and dynamic processes.
Journal ArticleDOI
Changes in biologically-active ultraviolet radiation reaching the Earth's surface
TL;DR: The Montreal Protocol is working as mentioned in this paper and ozone depletion is now decreasing, and the decline in total column amounts seen in the 1980s and 1990s at mid-latitudes has not continued.
Journal ArticleDOI
Sodium hyaluronate (hyaluronic acid) promotes migration of human corneal epithelial cells in vitro.
TL;DR: The beneficial effect of sodium hyaluronate in corneal wound healing is likely to be related to rapid migration of cells leading to rapid wound closure and may be facilitated by the adhesion between CD44 on the cells and hyaluronic acid, which coats the surface of the denuded cornea.
Journal ArticleDOI
Acute effects of UVR on human eyes and skin.
TL;DR: Tanning is modestly photoprotective against further acute UVR damage and skin colour is also transiently changed by UVA-dependent immediate pigment darkening, the function of which is unknown.
Journal Article
The ocular dose of ultraviolet radiation to outdoor workers.
TL;DR: The results provide parameters which can be used in modeling ocular UVR exposure in epidemiological and clinical studies and a seasonal effect on the ocular ambient exposure ratio (OAER) was also observed.