Changes in the osteocyte lacunocanalicular network with aging.
TLDR
A more complete understanding of the structure and function of the osteocyte network, its lacunocanalicular system, and the degenerative changes that occur with aging should lead to advances in the understanding of age related bone loss and potentially lead to improved therapies.About:
This article is published in Bone.The article was published on 2019-05-01 and is currently open access. It has received 52 citations till now. The article focuses on the topics: Osteocyte & Osteoblast.read more
Citations
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Journal Article
Epidemiology of osteoporotic fractures
TL;DR: Patients with vertebral, hip, distal radius, and proximal humerus fractures are most common among the osteoporosis-related fractures.
Journal ArticleDOI
Monocyte Chemoattractant Protein-1 (MCP-1/CCL2) Drives Activation of Bone Remodelling and Skeletal Metastasis
TL;DR: Monocyte chemoattractant protein-1’s role in bone remodelling and bone-related cancers highlights its potential as a novel anti-resorptive and anti-metastatic target.
Journal ArticleDOI
The mechanoresponse of bone is closely related to the osteocyte lacunocanalicular network architecture.
Alexander Van Tol,Alexander Van Tol,Victoria Schemenz,Victoria Schemenz,Wolfgang Wagermaier,Andreas Roschger,Andreas Roschger,Hajar Razi,Isabela Vitienes,Isabela Vitienes,Peter Fratzl,Bettina M. Willie,Bettina M. Willie,Richard Weinkamer +13 more
TL;DR: It is shown that considering the network architecture results in a better prediction of bone remodeling than mechanical strain alone, and is necessary to understand skeletal mechanobiology.
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Fructus Ligustri Lucidi preserves bone quality through the regulation of gut microbiota diversity, oxidative stress, TMAO and Sirt6 levels in aging mice.
Lin Li,Beibei Chen,Ruyuan Zhu,Rui Li,Yimiao Tian,Chenyue Liu,Qiangqiang Jia,Lili Wang,Jinfa Tang,Dandan Zhao,Fangfang Mo,Yan Liu,Yu Li,Alexander N. Orekhov,Dieter Brömme,Dongwei Zhang,Sihua Gao +16 more
TL;DR: It is demonstrated that sustained exposure of ICR mice to D-galactose / sodium nitrite for 90 days causes aging-related osteoporosis and reduced cognitive performance and FLL-treated aging mice revealed a non-osteoporotic bone phenotype and an improvement on the cognitive function.
Journal ArticleDOI
Crosstalk between Bone and Nerves within Bone.
Qian Qian Wan,Wen Pin Qin,Yu Xuan Ma,Min Juan Shen,Jing Li,Zi Bin Zhang,Ji Hua Chen,Franklin R. Tay,Li Na Niu,Kai Jiao +9 more
TL;DR: In this article, the possible crosstalk between bone and intrabony peripheral nerves is comprehensively analyzed and harnessed in the design of tissue engineering scaffolds for repair of bone defects or be targeted for treatment of diseases related to bone and peripheral nerves.
References
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Free radicals and antioxidants in normal physiological functions and human disease
TL;DR: Attention is focussed on the ROS/RNS-linked pathogenesis of cancer, cardiovascular disease, atherosclerosis, hypertension, ischemia/reperfusion injury, diabetes mellitus, neurodegenerative diseases, rheumatoid arthritis, and ageing.
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Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis
TL;DR: Tight genetic linkage between FALS and a gene that encodes a cytosolic, Cu/Zn-binding superoxide dismutase (SOD1), a homodimeric metalloenzyme that catalyzes the dismutation of the toxic superoxide anion O–2 to O2 and H2O2 is reported.
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An estimate of the worldwide prevalence and disability associated with osteoporotic fractures.
Olof Johnell,John A. Kanis +1 more
TL;DR: It is concluded that osteoporotic fractures are a significant cause of morbidity and mortality, particularly in the developed countries.
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The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression
TL;DR: A senescence-associated secretory phenotype (SASP) is acquired that turns senescent fibroblasts into proinflammatory cells that have the ability to promote tumor progression.
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Hip fractures in the elderly: A world-wide projection
TL;DR: In this article, the authors applied available incidence rates for hip fracture from various parts of the world to projected populations in 1990, 2025 and 2050 in order to estimate the numbers of hip fractures which might occur in each of the major continental regions.