Journal ArticleDOI
Chemical and anticancer activity studies for some 3-chloro-3-chlorosulfenyl-4′-methylspiro[chroman-2,1′-cyclohexane]-4-ones
Tamer El Malah,Ahmed H. Shamroukh,Eman R. Kotb,Hanan A. Soliman,Khaled Mahmoud,Mohamed I. Hegab +5 more
TLDR
In this paper, the reaction of spiro 4′-methylcyclohexan-1′,2-chroman-4-one with thionyl chloride according to re...Abstract:
3-Chloro-3-chlorosulfenyl-4′-methylspiro[chroman-2,1′-cyclohexane]-4-one (4) was prepared from the reaction of spiro 4′-methylcyclohexan-1′,2-chroman-4-one (3) with thionyl chloride according to re...read more
Citations
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Design, synthesis and structure-activity relationship studies of novel spirochromanone hydrochloride analogs as anticancer agents.
Surendar Chitti,Sravani Pulya,Adinarayana Nandikolla,Tarun Patel,Karan Kumar Banoth,Sankaranarayanan Murugesan,Balaram Ghosh,Venkata Gowri Chandra Sekhar Kondapalli +7 more
TL;DR: A molecular docking study of Csp 12 exhibited effective binding at the active site of the epidermal growth factor receptor kinase domain, highlighting the importance of spirochromanones as anticancer agents.
References
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Journal ArticleDOI
Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
TL;DR: A tetrazolium salt has been used to develop a quantitative colorimetric assay for mammalian cell survival and proliferation and is used to measure proliferative lymphokines, mitogen stimulations and complement-mediated lysis.
Journal ArticleDOI
Chalcones and flavonoids as anti-tuberculosis agents.
TL;DR: A hydrophobic substituent on one aromatic ring, and a hydrogen-bonding group on the other aromatic ring resulted in increased anti-TB activity of the chalcones and chalcone-like compounds.
Journal ArticleDOI
Enantioselective organocatalytic tandem Michael-Aldol reactions: one-pot synthesis of chiral thiochromenes.
TL;DR: A highly enantioselective diphenylpyrrolinol silyl ether promoted tandem Michael-aldol reaction of alpha,beta-unsaturated aldehydes with 2-mercaptobenzaldehydes has been developed and affords one-pot access to chiral and synthetically useful thiochromenes in high yields and high enantiOSElectivities from readily available compounds.
Journal ArticleDOI
Screening of hepatoprotective plant components using a HepG2 cell cytotoxicity assay
TL;DR: A screening assay has been developed based on protection of human liver‐derived HepG2 cells against toxic damage that is effective in quantifying the active components of plants with hepatoprotective properties during fractionation and purification.
Journal ArticleDOI
Synthesis, chromatographic resolution, and anti-human immunodeficiency virus activity of (±)-calanolide A and its enantiomers
Michael T. Flavin,John D. Rizzo,Albert Khilevich,Alla Kucherenko,Abram Kivovich Sheinkman,Vilayphone Vilaychack,Lin Lin,Wei Chen,Eugenia Mata Greenwood,Thitima Pengsuparp,John M. Pezzuto,Stephen H. Hughes,Thomas M. Flavin,Michael Cibulski,William A. Boulanger,Robert L. Shone,Ze-Qi Xu +16 more
TL;DR: The anti-HIV agent (+/-)-calanolide A (1) has been synthesized in a five-step approach starting with phloroglucinol, which includes Pechmann reaction, Friedel-Crafts acylation, chromenylation with 4,4-dimethoxy- 2-methylbutan-2-ol, cyclization, and Luche reduction.