Chemical and Pharmacological Studies of Saponins with a Focus on American Ginseng
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TLDR
Chemical analysis of saponins from these two ginsengs are discussed, including the effects on the cardiovascular system, immune system, and central nervous system as well as the antidiabetes and anti-cancer effects.About:
This article is published in Journal of Ginseng Research.The article was published on 2010-09-01 and is currently open access. It has received 138 citations till now. The article focuses on the topics: Asian Ginseng & American ginseng.read more
Citations
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Journal ArticleDOI
Chemical Diversity of Panax ginseng, Panax quinquifolium, and Panax notoginseng
TL;DR: Ginseng is the most commonly used as an adaptogenic agent and has been shown to enhance physical performance, promote vitality, increase resistance to stress and aging, and have immunomodulatory activity.
Journal ArticleDOI
Effects of Panax ginseng in Neurodegenerative Diseases
TL;DR: This review considers publications dealing with the various actions of P. ginseng that are indicative of possible neurotherapeutic efficacies in neurodegenerative diseases and neurological disorders such as Parkinson’s disease, Alzheimer's disease, Huntington’S disease, and amyotrophic lateral sclerosis and multiple sclerosis.
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Drug Interactions with Herbal Medicines
TL;DR: The present article summarizes herbal medicine-drug interactions involving mainly inhibition or induction of cytochrome P450 enzymes and/or drug transporters and describes the clinical implications of these interactions.
Journal ArticleDOI
Polysaccharides as vaccine adjuvants.
TL;DR: The present study systematically reviewed the recent studies on polysaccharides with vaccine adjuvant activities, including chitosan-based nanoparticles (NPs), glucan, mannose, inulinpolysaccharide and Chinese medicinal herb poly Saccharide, laying a foundation for the further development of polysacchide adjuvants.
Journal ArticleDOI
Biotransformation and metabolic profile of American ginseng saponins with human intestinal microflora by liquid chromatography quadrupole time-of-flight mass spectrometry.
Jin-Yi Wan,Peng Liu,Huaiyou Wang,Lian-Wen Qi,Lian-Wen Qi,Chong-Zhi Wang,Ping Li,Chun-Su Yuan +7 more
TL;DR: The biotransformation and metabolic profile of American ginseng extract by human intestinal microflora is studied and the three most abundant metabolites are 20S-ginsenoside Rg3, ginsenoside F2 and compound K.
References
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Journal ArticleDOI
Ginseng pharmacology: Multiple constituents and multiple actions
TL;DR: This commentary aims to review selected effects of ginseng and ginsenosides and describe their possible modes of action, structural and functional relationship to steroids, and potential targets of action.
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Herbal Medicines and Perioperative Care
TL;DR: During the preoperative evaluation, physicians should explicitly elicit and document a history of herbal medication use to prevent, recognize, and treat potentially serious problems associated with their use and discontinuation.
Book ChapterDOI
Ginsenosides: Chemistry, biosynthesis, analysis and potential health effects
TL;DR: Analytical techniques for the analysis of ginsenosides that are described in this chapter are thin-layer chromatography, high-performance liquid chromatography combined with various detectors, gas chromatography), colorimetry, enzyme immunoassays (EIA), capillary electrophoresis (CE), nuclear magnetic resonance (NMR) spectroscopy, and spectrophotometric methods.
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Antidiabetic Effects of Panax ginseng Berry Extract and the Identification of an Effective Component
Anoja S. Attele,Yun-Ping Zhou,Jing-Tian Xie,Ji An Wu,Liu Zhang,Lucy Dey,W. Pugh,Paul A. Rue,Kenneth S. Polonsky,Chun-Su Yuan +9 more
TL;DR: Antihyperglycemic and anti-obese effects of Panax ginseng berry extract and its major constituent, ginsenoside Re, in obese diabetic C57BL/6J ob/ ob mice and their lean littermates were evaluated, suggesting that other constituents in the extract have distinct pharmacological mechanisms on energy metabolism.
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Degradation of ginsenosides in humans after oral administration
TL;DR: It was shown that two hydrolysis products of the protopanaxatriol ginsenosides, namely G-Rh1 and G-F1 may reach the systemic circulation and are probably responsible for the action of ginseng in humans.