Chronic Liver Disease: Noninvasive Subharmonic Aided Pressure Estimation of Hepatic Venous Pressure Gradient
John R. Eisenbrey,Jaydev K. Dave,Valgerdur G. Halldorsdottir,Daniel A. Merton,Cynthia Miller,Jose M. Gonzalez,Priscilla Machado,Suhyun Park,Scott Dianis,Carl L. Chalek,Christopher E. Kim,Jeffrey P. Baliff,Kai Erik Thomenius,Daniel B. Brown,Victor Navarro,Flemming Forsberg +15 more
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TLDR
Preliminary results show SHAPE to be an accurate noninvasive technique for estimating portal hypertension, and may be a useful tool for the diagnosis of clinically important portal hypertension.Abstract:
In this study, we correlated subharmonic aided pressure estimation data with the hepatic venous pressure gradient and found good overall agreement, indicating that this noninvasive technique may be a useful screening tool for predicting the presence of clinically important portal hypertension in patients undergoing transjugular liver biopsy.read more
Citations
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Emerging non-invasive approaches for diagnosis and monitoring of portal hypertension.
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A Review of Phospholipid Encapsulated Ultrasound Contrast Agent Microbubble Physics.
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TL;DR: Cirrhosis is now seen as a dynamic disease able to progress and regress between the compensated and decompensated stages, leading to the advancement of individualized risk stratification in clinical practice.
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Origins of Portal Hypertension in Nonalcoholic Fatty Liver Disease
TL;DR: Improved methods of noninvasive portal venous pressure monitoring will hopefully give new insights into the pathobiology of NAFLD and help efforts to identify patients at increased risk for adverse outcomes and novel drug candidates targeting reversible components of aberrant sinusoidal circulation may prevent progression inNAFLD.
References
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A model to predict survival in patients with end‐stage liver disease
Patrick S. Kamath,Russell H. Wiesner,Michael Malinchoc,Walter K. Kremers,Terry M. Therneau,Catherine L. Kosberg,Gennaro D'Amico,E. Rolland Dickson,M.B.A. W. Ray Kim M.D. +8 more
TL;DR: The MELD scale is a reliable measure of mortality risk in patients with end‐stage liver disease and suitable for use as a disease severity index to determine organ allocation priorities in patient groups with a broader range of disease severity and etiology.
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A model to predict poor survival in patients undergoing transjugular intrahepatic portosystemic shunts.
Michael Malinchoc,Patrick S. Kamath,Fredric D. Gordon,Craig J. Peine,Jeffrey M. Rank,Pieter C.J. ter Borg +5 more
TL;DR: This Mayo TIPS model may predict early death following elective TIPS for either prevention of variceal rebleeding or for treatment of refractory ascites, superior to both the Child‐Pugh classification and the Child-Pugh score in predicting survival.
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TL;DR: The natural history of cirrhosis is outlined, the model for end stage liver disease (MELD) has replaced the Child–Pugh score in the United States for prioritizing liver donor allocation and a systematic review of the literature regarding predictors of mortality in cirrhotic patients is reported on.
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Chronic hepatitis. An update on terminology and reporting.
Kenneth P. Batts,Jurgen Ludwig +1 more
TL;DR: For the reporting practice of pathologists, it is recommended that the pathologist routinely sign out biopsy samples with features of chronic hepatitis by indicating etiology, grade, and stage, which eliminates ambiguous terminology and avoids the risk of inappropriate treatment.
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Portal pressure, presence of gastroesophageal varices and variceal bleeding.
Guadalupe Garcia-Tsao,Roberto J. Groszmann,Rosemarie L. Fisher,Harold O. Conn,Colin E. Atterbury,Morton G. Glickman +5 more
TL;DR: This study was performed to examine the relationships between portal pressure measurements and the presence of esophagogastric varices, the size of varices and the occurrence of hemorrhage from varices in 93 patients with alcoholic cirrhosis, using standardized measurements of portal pressure by hepatic vein catheterization.