Circulating CD31+/Annexin V+ microparticles correlate with cardiovascular outcomes.
TLDR
The level of circulating CD31+/Annexin V+ MPs is an independent predictor of cardiovascular events in stable CAD patients and may be useful for risk stratification.Abstract:
Aims CD31+/Annexin V+ microparticles (MPs) are increased in patients with cardiovascular risk factors and impaired coronary endothelial function. We evaluated whether MPs are an independent marker for cardiovascular events in patients with stable coronary artery disease (CAD).
Methods and results The number of CD31+/Annexin V+ MP was determined by flow cytometry in 200 patients (age 66.1 ± 10.4 years) and correlated with cardiovascular outcomes. The median follow-up time for major adverse cardiovascular and cerebral event (MACCE)-free survival was 6.1 (6.0/6.4) years. Four patients were lost to follow-up. A first MACCE occurred in 72 patients (37%). Microparticle levels were significantly higher in patients with MACCE compared with patients without event ( P = 0.004). The prevalence of diabetes ( P = 0.02) and male gender ( P = 0.05) was significantly related to the MP level. In multivariate analysis (cardiovascular risk factors, number of diseased vessels, use of angiotensin-converting enzyme-inhibitors and statins), high MP levels were associated with a higher risk for cardiovascular death [Hazard ratio (HR) 4.0, 95% confidence interval (CI) 1.1–14.6; P = 0.04], the need for revascularization (HR 2.4, 95% CI 1.3–4.4; P = 0.005), and the occurrence of a first MACCE (HR 2.3, 95% CI 1.4–3.8; P = 0.001). Inclusion of the MP level into a classical risk factor model substantially increased c -statistics from 0.637 (95% CI: 0.557–0.717) to 0.702 (95% CI: 0.625–0.780) ( P = 0.03).
Conclusion The level of circulating CD31+/Annexin V+ MPs is an independent predictor of cardiovascular events in stable CAD patients and may be useful for risk stratification.read more
Citations
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Diabetes and vascular disease: pathophysiology, clinical consequences, and medical therapy: part I
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TL;DR: High levels of MPs circulate in the blood of patients with atherothrombotic diseases, where they could serve as a useful biomarker of vascular injury and a potential predictor of cardiovascular mortality and major adverse cardiovascular events.
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Dylan Burger,Sarah C. Schock,Charlie S. Thompson,Augusto C. Montezano,Antoine M. Hakim,Rhian M. Touyz,Rhian M. Touyz +6 more
TL;DR: The present review examines the evidence for microparticles as both biomarkers of, and contributors to, the progression of disease and novel concepts relating to the formation of microparticle and their biological effects are examined.
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