Journal ArticleDOI
Extracellular vesicles in coronary artery disease
Chantal M. Boulanger,Chantal M. Boulanger,Xavier Loyer,Xavier Loyer,Pierre-Emmanuel Rautou,Pierre-Emmanuel Rautou,Nicolas Amabile +6 more
TLDR
Current knowledge on the role of extracellular vesicles in coronary artery disease, and their emerging potential as biomarkers and therapeutic agents are summarized.Abstract:
Membrane vesicles released in the extracellular space are composed of a lipid bilayer enclosing soluble cytosolic material and nuclear components. Extracellular vesicles include apoptotic bodies, exosomes, and microvesicles (also known previously as microparticles). Originating from different subcellular compartments, the role of extracellular vesicles as regulators of transfer of biological information, acting locally and remotely, is now acknowledged. Circulating vesicles released from platelets, erythrocytes, leukocytes, and endothelial cells contain potential valuable biological information for biomarker discovery in primary and secondary prevention of coronary artery disease. Extracellular vesicles also accumulate in human atherosclerotic plaques, where they affect major biological pathways, including inflammation, proliferation, thrombosis, calcification, and vasoactive responses. Extracellular vesicles also recapitulate the beneficial effect of stem cells to treat cardiac consequences of acute myocardial infarction, and now emerge as an attractive alternative to cell therapy, opening new avenues to vectorize biological information to target tissues. Although interest in microvesicles in the cardiovascular field emerged about 2 decades ago, that for extracellular vesicles, in particular exosomes, started to unfold a decade ago, opening new research and therapeutic avenues. This Review summarizes current knowledge on the role of extracellular vesicles in coronary artery disease, and their emerging potential as biomarkers and therapeutic agents.read more
Citations
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Journal ArticleDOI
New Technologies for Analysis of Extracellular Vesicles
TL;DR: This article aims to present a comprehensive and critical overview of emerging analytical technologies for EV detection and their clinical applications.
Journal ArticleDOI
Exosomes and Ectosomes in Intercellular Communication
TL;DR: Exosomes and ectosomes, two distinct types of extracellular vesicles generated by all types of cell, play key roles in intercellular communication and are useful in the development of innovative therapeutic approaches.
Journal ArticleDOI
Extracellular vesicles in diagnostics and therapy of the ischaemic heart: Position Paper from the Working Group on Cellular Biology of the Heart of the European Society of Cardiology
Joost Petrus Gerardus Sluijter,Sean M. Davidson,Chantal M. Boulanger,Edit I. Buzás,Dominique de Kleijn,Felix B. Engel,Zoltán Giricz,Derek J. Hausenloy,Raj Kishore,Sandrine Lecour,Jonathan Leor,Rosalinda Madonna,Rosalinda Madonna,Rosalinda Madonna,Cinzia Perrino,Fabrice Prunier,Susmita Sahoo,Raymond M. Schiffelers,Rainer Schulz,Linda W. van Laake,Kirsti Ytrehus,Péter Ferdinandy +21 more
TL;DR: The overall objective is to provide a set of recommendations for the analysis and translational application of EVs focussing on the diagnosis and therapy of the ischaemic heart, to ensure that the data from emerging studies are robust and repeatable, and optimize the pathway towards the diagnostic and therapeutic use of EVs in clinical studies for patient benefit.
Journal ArticleDOI
Transplanted Mesenchymal Stem Cells Reduce Autophagic Flux in Infarcted Hearts via the Exosomal Transfer of miR-125b.
Changchen Xiao,Kan Wang,Yinchuan Xu,Hengxun Hu,Na Zhang,Yingchao Wang,Zhiwei Zhong,Jing Zhao,Qingju Li,Dan Zhu,Changle Ke,Shuhan Zhong,Xianpeng Wu,Hong Yu,Wei Zhu,Jinghai Chen,Jianyi Zhang,Jian-an Wang,Xinyang Hu +18 more
TL;DR: The beneficial effects offered by MSC transplantation after myocardial infarction are at least partially because of improved autophagic flux through excreted exosome containing mainly miR-125b-5p.
Journal ArticleDOI
Endothelial cell apoptosis and the role of endothelial cell-derived extracellular vesicles in the progression of atherosclerosis.
TL;DR: A review of the known causes and consequences of endothelial cell death during atherosclerosis along with highlighting current methodological approaches to studying EndoEVs and the potential roles of Endo-EVs in atherogenic development is provided in this paper.
References
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Journal ArticleDOI
Biological properties of extracellular vesicles and their physiological functions
María Yáñez-Mó,Pia Siljander,Zoraida Andreu,Apolonija Bedina Zavec,Francesc E. Borràs,Edit I. Buzás,Krisztina Buzas,Krisztina Buzas,Enriqueta Casal,Francesco Cappello,Joana Carvalho,Joana Carvalho,Eva Colas,Anabela Cordeiro da Silva,Anabela Cordeiro da Silva,Stefano Fais,Juan M. Falcón-Pérez,Irene M. Ghobrial,Bernd Giebel,Mario Gimona,Mario Gimona,Michael W. Graner,Ihsan Gursel,Mayda Gursel,Niels H. H. Heegaard,Niels H. H. Heegaard,An Hendrix,Peter Kierulf,Katsutoshi Kokubun,Maja Kosanović,Veronika Kralj-Iglič,Eva-Maria Krämer-Albers,Saara Laitinen,Cecilia Lässer,Thomas Lener,Thomas Lener,Erzsébet Ligeti,Aija Linē,Georg Lipps,Alicia Llorente,Jan Lötvall,Mateja Manček-Keber,Antonio Marcilla,María Mittelbrunn,Irina Nazarenko,Esther N. M. Nolte-‘t Hoen,Tuula A. Nyman,Lorraine O'Driscoll,Mireia Olivan,Carla Oliveira,Carla Oliveira,Éva Pállinger,Hernando A. del Portillo,Hernando A. del Portillo,Jaume Reventós,Jaume Reventós,Marina Rigau,Eva Rohde,Eva Rohde,Marei Sammar,Francisco Sánchez-Madrid,Nuno Santarém,Nuno Santarém,Katharina Schallmoser,Katharina Schallmoser,Marie Stampe Ostenfeld,Willem Stoorvogel,Roman Štukelj,Susanne G. van der Grein,M. Helena Vasconcelos,M. Helena Vasconcelos,Marca H. M. Wauben,Olivier De Wever +72 more
TL;DR: A comprehensive overview of the current understanding of the physiological roles of EVs is provided, drawing on the unique EV expertise of academia-based scientists, clinicians and industry based in 27 European countries, the United States and Australia.
Journal ArticleDOI
Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma
Jason D. Arroyo,John R. Chevillet,Evan M. Kroh,Ingrid K. Ruf,Colin C. Pritchard,Donald F. Gibson,Patrick S. Mitchell,Christopher F. Bennett,Era L. Pogosova-Agadjanyan,Derek L. Stirewalt,Jonathan F. Tait,Muneesh Tewari +11 more
TL;DR: Identification of extracellular Ago2–miRNA complexes in plasma raises the possibility that cells release a functional miRNA-induced silencing complex into the circulation, and reveals two populations of circulating miRNAs and suggest that circulating Ago2 complexes are a mechanism responsible for the stability of plasma mi RNAs.
Journal ArticleDOI
MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins
TL;DR: Evidence that high-density lipoprotein (HDL) transports endogenous miRNAs and delivers them to recipient cells with functional targeting capabilities is presented, indicating that HDL participates in a mechanism of intercellular communication involving the transport and delivery of miRNA.
Journal ArticleDOI
Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes.
Joanna Kowal,Guillaume Arras,Marina Colombo,Mabel Jouve,Jakob Paul Morath,Bjarke Primdal-Bengtson,Florent Dingli,Damarys Loew,Mercedes Tkach,Clotilde Théry +9 more
TL;DR: This work demonstrates the presence of exosomal and nonexosomal subpopulations within small EVs, and proposes their differential separation by immuno-isolation using either CD63, CD81, or CD9, and provides guidelines to define subtypes of EVs for future functional studies.
Journal ArticleDOI
Standardization of sample collection, isolation and analysis methods in extracellular vesicle research
Kenneth W. Witwer,Edit I. Buzás,Lynne T. Bemis,Adriana Bora,Cecilia Lässer,Jan Lötvall,Esther Nolte-‘t Hoen,Melissa G. Piper,Sarada Sivaraman,Johan Skog,Clotilde Théry,Marca H. M. Wauben,Fred H. Hochberg +12 more
TL;DR: The need for standardization of specimen handling, appropriate normative controls, and isolation and analysis techniques to facilitate comparison of results is emphasized, and it is recognized that continual development and evaluation of techniques will be necessary as new knowledge is amassed.
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