Clock mutations alter developmental timing in Drosophila.
C. P. Kyriacou,M Oldroyd,Jo Wood,M. G. F. Sharp,M Hill +4 more
- Vol. 64, Iss: 3, pp 395-401
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TLDR
The developmental time of period mutants in Drosophila melanogaster was monitored and it was observed that the pers mutants, which have short 19 h circadian cycles, develop faster from eggs to adult than the wild-type: perL mutants, who have long 28 h circadian rhythms, complete development more slowly than theWild-type.Abstract:
The developmental time of period mutants in Drosophila melanogaster was monitored under different environmental conditions. We observed that the pers mutants, which have short 19 h circadian cycles, develop faster from eggs to adult than the wild-type: perL mutants, which have long 28 h circadian rhythms, complete development more slowly than the wild-type. These results suggest that endogenous timers may be involved in regulating the development time of D. melanogaster.read more
Citations
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Resonating circadian clocks enhance fitness in cyanobacteria
TL;DR: This work tested the adaptive significance of circadian programming by measuring the relative fitness under competition between various strains of cyanobacteria expressing different circadian periods and found strains that had a circadian period similar to that of the light/dark cycle were favored under competition in a manner that indicates the action of soft selection.
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The mating of a fly
TL;DR: Courtship in Drosophila is influenced by a wide variety of genes, in that many different kinds of pleiotropic mutations lead to defective courtship; the broad temporal and spatial expression of most of the fly's "neuro genes" makes it difficult to exclude elements of such genes' actions as materially underlying reproductive behavior.
Journal ArticleDOI
Trippings along the trail to the molecular mechanisms of biological clocks
TL;DR: Investigations that involve negatively acting transcription factors and other clock molecules that are presumed to interact with them should permit chronogeneticists to unravel further details of how the clock works, how environmental information finds its way to it, and how it sends information out into the organism's physiology, biochemistry and behavior.
Book
Genetics and Molecular Biology of Rhythms in Drosophila and Other Insects
TL;DR: These clock mechanisms are being analyzed in ways that are increasingly complex and occasionally obscure; not all panels of this picture are comprehensive or clear, including problems revolving round the biological meaning or a given features of all this molecular cycling
Journal ArticleDOI
Loss of circadian clock function decreases reproductive fitness in males of Drosophila melanogaster.
TL;DR: A circadian clock in the reproductive system is identified and its role in the sperm release that promotes reproductive fitness in D. melanogaster is defined and reversed by reversal of the low-fertility phenotype in flies with rescued per or tim function.
References
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Book
Nonparametric statistics for the behavioral sciences
TL;DR: This is the revision of the classic text in the field, adding two new chapters and thoroughly updating all others as discussed by the authors, and the original structure is retained, and the book continues to serve as a combined text/reference.
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Clock Mutants of Drosophila melanogaster
Ronald J. Konopka,Seymour Benzer +1 more
TL;DR: Three mutants have been isolated in which the normal 24-hour rhythm is drastically changed and all these mutations appear to involve the same functional gene on the X chromosome.
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A clock and wavefront model for control of the number of repeated structures during animal morphogenesis
J. Cooke,E. C. Zeeman +1 more
TL;DR: It is argued that the elements, a smooth oscillator, a slow wavefront and a rapid cellular change, have biological plausibility and are compatible with experimental observations such as the sequential formation of somites from anterior to posterior in a regular time sequence, the timing of cellular change during development generally, and the increasing evidence for widespread existence of cellular biorhythms.
Journal ArticleDOI
Restoration of circadian behavioural rhythms by gene transfer in Drosophila
TL;DR: It is reported that when a 7.1-kb fragment from a per+ fly, including the sequences encoding the 4.5-kb transcript, is introduced into the genome of a per0 (arrhythmic) fly by P element-mediated transformation, circadian rhythmicity of behaviour such as eclosion and locomotor activity is restored.
Journal ArticleDOI
Antibodies to the period gene product of drosophila reveal diverse tissue distribution and rhythmic changes in the visual system
TL;DR: The intensity of per-specific staining in the visual system was found to oscillate, defining a free-running circadian rhythm with a peak in the middle of the night.