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Journal ArticleDOI

Coffee Reduces Risk for Hepatocellular Carcinoma: An Updated Meta-analysis

TLDR
A meta-analysis of epidemiological studies to provide updated information on how coffee drinking affects HCC risk found the risk of HCC is reduced by 40% for any coffee consumption vs no consumption, and therefore could protect against liver carcinogenesis.
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This article is published in Clinical Gastroenterology and Hepatology.The article was published on 2013-11-01. It has received 212 citations till now.

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Journal ArticleDOI

Treatment of NAFLD with diet, physical activity and exercise

TL;DR: Clinical evidence strongly supports the role of lifestyle modification as a primary therapy for the management of NAFLD and NASH and should be accompanied by the implementation of strategies to avoid relapse and weight regain.
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Global epidemiology of hepatocellular carcinoma: an emphasis on demographic and regional variability.

TL;DR: Obesity, metabolic syndrome, and diabetes are increasing in developed and developing countries and will lead to more cases of HCC and new infections with hepatitis C virus are low in developed countries.
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Epidemiology of hepatocellular carcinoma in the United States: Where are we? Where do we go?

TL;DR: The age distribution of HCC patients has shifted to younger ages, with the greatest proportional increases among individuals 45-60 years old, and HCC incidence rates are reported to be higher among Hispanics born in the United States than among foreign-born Hispanics.
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Hepatocellular carcinoma epidemiology

TL;DR: In this article, a review of hepatocellular carcinoma (HCC) in Europe, USA, Japan, and Australia is presented, together with an overview of relevant etiologic factors for HCC and main measures for the prevention of this neoplasm.
References
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Journal ArticleDOI

Global cancer statistics

TL;DR: A substantial proportion of the worldwide burden of cancer could be prevented through the application of existing cancer control knowledge and by implementing programs for tobacco control, vaccination, and early detection and treatment, as well as public health campaigns promoting physical activity and a healthier dietary intake.
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Bias in meta-analysis detected by a simple, graphical test

TL;DR: Funnel plots, plots of the trials' effect estimates against sample size, are skewed and asymmetrical in the presence of publication bias and other biases Funnel plot asymmetry, measured by regression analysis, predicts discordance of results when meta-analyses are compared with single large trials.
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Quantifying heterogeneity in a meta‐analysis

TL;DR: It is concluded that H and I2, which can usually be calculated for published meta-analyses, are particularly useful summaries of the impact of heterogeneity, and one or both should be presented in publishedMeta-an analyses in preference to the test for heterogeneity.
Journal ArticleDOI

Meta-analysis of observational studies in epidemiology - A proposal for reporting

TL;DR: A checklist contains specifications for reporting of meta-analyses of observational studies in epidemiology, including background, search strategy, methods, results, discussion, and conclusion should improve the usefulness ofMeta-an analyses for authors, reviewers, editors, readers, and decision makers.
Journal ArticleDOI

Methods for Trend Estimation from Summarized Dose-Response Data, with Applications to Meta-Analysis

TL;DR: The authors propose two methods that account for the correlations but require only the summary estimates and marginal data from the studies, which provide more efficient estimates of regression slope, more accurate variance estimates, and more valid heterogeneity tests than those previously available.
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