Journal ArticleDOI
Cognitive enhancing effects in young and old rats of pBC264, a selective CCKB receptor agonist
TLDR
Propionyl-BC264, a selective agonist of CCKB receptors, is of value in the treatment of cognitive impairments associated with both normal and pathological ageing and is devoid of anxiogenic effects.Abstract:
Rationale: The implication of CCKB receptors in cognitive processes is far from fully understood. Objective: The present study investigated the effect of propionyl-BC264, a selective agonist of CCKB receptors, in young and old rats. Methods: Cognitive functions were studied in a two-trial recognition memory task developed in our laboratory. Results: It was shown that propionyl-BC264 enhanced information processing in young as well as in old rats when injected (10 μg/kg; IP) immediately after the acquisition phase and before the retrieval trial but not before the acquisition trial. This cognitive enhancing effect was blocked by prior administration of L 365,260, a selective CCKB receptor antagonist. Conclusions: In view of the fact that BC264 is devoid of anxiogenic effects, it could be of value in the treatment of cognitive impairments associated with both normal and pathological ageing.read more
Citations
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International Union of Pharmacology. XXI. Structure, distribution, and functions of cholecystokinin receptors.
Florence Noble,Stephen A. Wank,Jacqueline N. Crawley,Jacques Bradwejn,Kim B. Seroogy,M. Hamon,Bernard P. Roques +6 more
TL;DR: The peptide cholecystokinin has been shown to mediate pancreatic secretion and contraction of gallbladder and was described in the mammalian central nervous system (CNS) as a gastrin-like peptide.
Journal ArticleDOI
CCK-B receptor: chemistry, molecular biology, biochemistry and pharmacology
Florence Noble,Bernard P. Roques +1 more
TL;DR: The strategies followed to design these probes, and their use to study the anatomy of CCK pathways, the neurochemical and pharmacological properties of this peptide and the clinical perspectives offered by manipulation of the CCK system will be reported.
Journal ArticleDOI
Cholecystokinin and endogenous opioid peptides: interactive influence on pain, cognition, and emotion.
TL;DR: While CCK induces relatively protracted behavioral disturbances in both animal and human subjects following stressor applications, opioid receptor activation may change the course of psychopathology, the antagonistic interaction of CCK and opioid peptides is evident in psychological disturbances as well as stress-induced analgesia.
Journal ArticleDOI
CCK in anxiety and cognitive processes.
Valérie Daugé,Isabelle Léna +1 more
TL;DR: Investigations into CCK-B1 and CCk-B2 systems might be of critical interest, since only one site appears to be responsible for the effects of anxiety, and the improvement of attention and/or memory processes by CCK, through CCK -B2 receptors, could offer a new perspective in the treatment of attention or memory disorders.
Journal ArticleDOI
The state of GPCR research in 2004
TL;DR: 20 questions of fundamental importance to the future development of the field are posed to 20 of the world's leading experts on GPCR research, and here are their replies.
References
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Dissociation of Object and Spatial Processing Domains in Primate Prefrontal Cortex
TL;DR: These findings indicate that the prefrontal cortex contains separate processing mechanisms for remembering "what" and "where" an object is.
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A triple dissociation of memory systems: hippocampus, amygdala, and dorsal striatum
TL;DR: The results of this study are consistent with the hypothesis that the mammalian brain may be capable of acquiring different kinds of information with different, more-or-less independent neural systems.
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Chronic stress impairs rat spatial memory on the Y maze, and this effect is blocked by tianeptine pretreatment.
TL;DR: Results from Experiment 4 showed that chronic restraint stress impaired spatial memory performance on the Y maze when rats were tested the day after the last stress session and that tianeptine prevented the stress-induced spatial memory impairment.
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Two brain cholecystokinin receptors: implications for behavioral actions.
TL;DR: The distribution and relative specificity of cholecystokinin receptors in the rat brain was mapped by in vitro autoradiography with [125I]CCK-33 and two distinct binding patterns were identified, suggesting two CCK receptor types.