Journal ArticleDOI
Coinfection of hepatitis C virus in patients with chronic hepatitis B infection
Shinjiro Sato,Shigetoshi Fujiyama,Motohiko Tanaka,Kunio Yamasaki,Izumi Kuramoto,Shin ichi Kawano,Tatsuo Sato,Kyosuke Mizuno,Saneo Nonaka +8 more
TLDR
Results show that hepatitis C virus appears to be the primary cause of active hepatitis in most patients with hepatitis B and hepatitis C viruses coinfection.About:
This article is published in Journal of Hepatology.The article was published on 1994-01-01. It has received 152 citations till now. The article focuses on the topics: Hepatitis B virus DNA polymerase & Hepatitis B virus.read more
Citations
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Hepatocellular carcinoma: Epidemiology, risk factors and pathogenesis
TL;DR: The international epidemiology, the risk factors and the pathogenesis of HCC are summarized, including the roles of viral hepatitis, toxins, such as alcohol and aflatoxin, and insulin resistance.
Occult hepatitis b virus infection in patients with chronic hepatiis c liver disease
TL;DR: In this paper, the authors search for hepatitis B virus (HBV) DNA in liver and serum samples from 200 HBsAg-negative patients with hepatitis C virus (HCV)-related liver disease (147 with chronic hepatitis, 48 with cirrhosis, and 5 with minimal histologic changes).
Journal ArticleDOI
Occult hepatitis B virus infection
TL;DR: Much evidence suggests that hepatitis B virus can favour the progression of liver fibrosis and above all the development of hepatocellular carcinoma, and is an entity with world-wide diffusion.
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Occult hepatitis B virus infection in patients with chronic hepatitis C liver disease.
Irene Cacciola,Teresa Pollicino,Giovanni Squadrito,Giovanni Cerenzia,Maria Elena Orlando,Giovanni Raimondo +5 more
TL;DR: Occult hepatitis B infection occurs frequently in patients with chronic hepatitis C liver disease and may have clinical significance, and none of the sequenced HBV genomes had changes known to interfere with viral activity and gene expression.
Journal ArticleDOI
Characteristics of patients with dual infection by hepatitis B and C viruses
Jean-Pierre Zarski,Benoit Bohn,Anne Bastie,Jean-Michel Pawlotsky,Maryline Baud,Frédérique Bost-Bezeaux,Jeanne Tran Van Nhieu,Jean-Marie Seigneurin,Catherine Buffet,Daniel Dhumeaux +9 more
TL;DR: It is suggested that HBV DNA replication inhibits HCV RNA replication in patients with chronic active hepatitis B and C but increases the severity of histological lesions.
References
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Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
TL;DR: A new method of total RNA isolation by a single extraction with an acid guanidinium thiocyanate-phenol-chloroform mixture is described, providing a pure preparation of undegraded RNA in high yield and can be completed within 4 h.
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Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase
Randall Keichi Saiki,David H. Gelfand,Susanne Stoffel,Stephen J. Scharf,Russell Higuchi,Glenn Thomas Horn,Kary B. Mullis,Henry A. Erlich +7 more
TL;DR: A thermostable DNA polymerase was used in an in vitro DNA amplification procedure, the polymerase chain reaction, which significantly improves the specificity, yield, sensitivity, and length of products that can be amplified.
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Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome
TL;DR: A random-primed complementary DNA library was constructed from plasma containing the uncharacterized non-A, non-B hepatitis agent and screened with serum from a patient diagnosed with NANBH, showing consistent with the agent being similar to the togaviridae or flaviviridae.
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An assay for circulating antibodies to a major etiologic virus of human non-A, non-B hepatitis
George Kuo,Q L Choo,Harvey J. Alter,G.L. Gitnick,Allan G. Redeker,Robert H. Purcell,Tatsuo Miyamura,Jules L. Dienstag,M.J. Alter,Cladd E. Stevens,Gary E. Tegtmeier,Ferruccio Bonino,Massimo Colombo,W.-S. Lee,C. Kuo,K. Berger,Jeffrey R. Shuster,Lacy Rasco Overby,Daniel W. Bradley,Michael Houghton +19 more
TL;DR: Assays of ten blood transfusions in the United States that resulted in chronic NANBH revealed that there was at least one positive blood donor in nine of these cases and that all ten recipients seroconverted during their illnesses.
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The hepatitis B virus
TL;DR: In this paper, the hepatitis B virus (HBV) virology has been analyzed and recombinant DNA recombinant technology has been used for the development of new vaccines for hepatocellular carcinoma.