Colitis-Associated Variant of TLR2 Causes Impaired Mucosal Repair Because of TFF3 Deficiency
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TLDR
A novel function of TLR2 in intestinal GC that links products of commensal bacteria to innate immune protection of the host via TFF3 is demonstrated.About:
This article is published in Gastroenterology.The article was published on 2009-07-01 and is currently open access. It has received 218 citations till now. The article focuses on the topics: Intestinal mucosa & TLR2.read more
Citations
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Journal ArticleDOI
Intestinal epithelial cells: regulators of barrier function and immune homeostasis
Lance W. Peterson,David Artis +1 more
TL;DR: This Review provides a comprehensive overview of how IECs maintain host–commensal microbial relationships and immune cell homeostasis in the intestine.
Journal ArticleDOI
Toll-like receptor signalling in the intestinal epithelium: how bacterial recognition shapes intestinal function
TL;DR: Dysregulated TLR signalling by intestinal epithelial cells may explain how colonic bacteria and inflammation promote colorectal cancer.
Journal ArticleDOI
Intestinal Goblet Cells and Mucins in Health and Disease: Recent Insights and Progress
TL;DR: The mucus layer coating the gastrointestinal tract is the front line of innate host defense, largely because of the secretory products of intestinal goblet cells, and elucidation of the regulatory mechanisms involved in mucin changes in cancer and inflammation may lead to the development of novel therapeutic approaches.
Journal ArticleDOI
Gut microbiota and IBD: causation or correlation?
TL;DR: Current associations between IBD and dysbiosis are summarized, the role of the gut microbiota in the context of specific animal models of colitis is described, and the potential role of microbiota-focused interventions in the treatment of human IBD is discussed.
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Chemically induced mouse models of acute and chronic intestinal inflammation
Stefan Wirtz,Vanessa Popp,Markus Kindermann,Katharina Gerlach,Benno Weigmann,Stefan Fichtner-Feigl,Markus F. Neurath +6 more
TL;DR: This protocol update describes an adaptation of the existing protocol that modifies the technique that has been used to generate improved mouse models that better reflect the nature of IBDs in humans.
References
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Journal ArticleDOI
Recognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis
Seth Rakoff-Nahoum,Justin C. Paglino,Fatima Eslami-Varzaneh,Stephen C. Edberg,Ruslan Medzhitov +4 more
TL;DR: It is shown that commensal bacteria are recognized by TLRs under normal steady-state conditions, and this interaction plays a crucial role in the maintenance of intestinal epithelial homeostasis and protection from injury.
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Unravelling the pathogenesis of inflammatory bowel disease
TL;DR: Recently, substantial advances in the understanding of the molecular pathogenesis of inflammatory bowel disease (IBD) have been made owing to three related lines of investigation as mentioned in this paper, which have shown the importance of epithelial barrier function, and innate and adaptive immunity in disease pathogenesis.
Journal ArticleDOI
Molecular Analysis of Commensal Host-Microbial Relationships in the Intestine
TL;DR: Coloring germ-free mice with Bacteroides thetaiotaomicron reveals that this commensal bacterium modulates expression of genes involved in several important intestinal functions, including nutrient absorption, mucosal barrier fortification, xenobiotic metabolism, angiogenesis, and postnatal intestinal maturation.
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Differential Alteration in Intestinal Epithelial Cell Expression of Toll-Like Receptor 3 (TLR3) and TLR4 in Inflammatory Bowel Disease
Elke Cario,Daniel K. Podolsky +1 more
TL;DR: The data suggest that IBD may be associated with distinctive changes in selective TLR expression in the intestinal epithelium, implying that alterations in the innate response system may contribute to the pathogenesis of these disorders.
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Crystal Structure of the TLR1-TLR2 Heterodimer Induced by Binding of a Tri-Acylated Lipopeptide
Mi Sun Jin,Sung-Eun Kim,Jin Young Heo,Mi Eun Lee,Ho Min Kim,Sang-Gi Paik,Hayyoung Lee,Jie-Oh Lee +7 more
TL;DR: It is proposed that formation of the TLR1-TLR2 heterodimer brings the intracellular TIR domains close to each other to promote dimerization and initiate signaling.
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Differential Alteration in Intestinal Epithelial Cell Expression of Toll-Like Receptor 3 (TLR3) and TLR4 in Inflammatory Bowel Disease
Elke Cario,Daniel K. Podolsky +1 more