Combating COVID-19: The role of drug repurposing and medicinal plants
Shah Alam Khan,K. Al-Balushi +1 more
TLDR
The aim of this mini-review is to give an overview of identified repurposed anti-COVID-19 drugs which are currently under clinical trials and explore antiviral medicinal plants as adjunct or supportive therapy.About:
This article is published in Journal of Infection and Public Health.The article was published on 2021-04-01 and is currently open access. It has received 40 citations till now. The article focuses on the topics: Literature survey & Drug repositioning.read more
Citations
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Journal ArticleDOI
Discovery, Development, and Patent Trends on Molnupiravir: A Prospective Oral Treatment for COVID-19.
Mohd. Imran,Mandeep Kumar Arora,Syed Mohammed Basheeruddin Asdaq,Shah Alam Khan,Saleh I. Alaqel,Mohammed Kanan Alshammari,Mohammed M. Alshehri,Ahmed Subeh Alshrari,Alreshidi Mateq Ali,Ahmed Muteb Al-Shammeri,Bushra Dhuhayyan Alhazmi,Aishah Ali Harshan,Tauquir Alam +12 more
TL;DR: Molnupiravir as mentioned in this paper, an orally active RdRp inhibitor, is in a phase 3 clinical trial against COVID-19 and has shown good safety profile, tolerability, and oral bioavailability in humans.
Journal ArticleDOI
Recent advances on drug development and emerging therapeutic agents for Alzheimer's disease.
TL;DR: A brief review article is intended to cover the recent advances in drug development and emerging therapeutic agents for Alzheimer's disease acting at different targets as discussed by the authors, which is concluded that novel therapeutic strategies are required to discover and develop therapeutic agents to fight against the century old AD.
Journal ArticleDOI
Use of medicinal plants for COVID-19 prevention and respiratory symptom treatment during the pandemic in Cusco, Peru: A cross-sectional survey.
Magaly Villena-Tejada,Ingrid Vera-Ferchau,Anahí Cardona-Rivero,Rina Zamalloa-Cornejo,Mercedes Maritza Quispe-Flórez,Zany Frisancho-Triveno,Rosario C Abarca-Melendez,Susan G Alvarez-Sucari,Christian R. Mejia,Jaime A. Yáñez +9 more
TL;DR: In this article, a web-based cross-sectional study was conducted on general public (20-to 70-year-old) from August 31 to September 20, 2020.
Journal ArticleDOI
The find of COVID-19 vaccine: Challenges and opportunities
Marwan ElBagoury,Mahmoud M. Tolba,Hebatallah A. Nasser,Abdul Jabbar,Ahmed M. Elagouz,Yahia Aktham,Amy Hutchinson +6 more
TL;DR: Wang et al. as mentioned in this paper presented a comprehensive visualization about SARS-CoV-2 to tackle the current pandemic and concluded that vaccines formulation within exceptional no time in this pandemic is highly recommended.
Peer ReviewDOI
A Comprehensive Review of Drug Repurposing Strategies against Known Drug Targets of COVID-19
TL;DR: This review attempts to collate both the experimental and computational drug repurposing strategies that have been utilized against significant drug targets of SARS-CoV-2 and the available druggable targets shall also be discussed.
References
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In silico screening of Chinese herbal medicines with the potential to directly inhibit 2019 novel coronavirus.
TL;DR: A rational screen to identify Chinese medical herbs that are commonly used in treating viral respiratory infections and also contain compounds that might directly inhibit 2019 novel coronavirus (2019-nCoV), an ongoing novel coronvirus that causes pneumonia is executed.
Journal ArticleDOI
Drug targets for corona virus: A systematic review.
Manisha Prajapat,Phulen Sarma,Nishant Shekhar,Pramod Avti,Shweta Sinha,Hardeep Kaur,Subodh Kumar,Anusuya Bhattacharyya,Harish Kumar,Seema Bansal,Bikash Medhi +10 more
TL;DR: The occurrence of frequent recombination events is a major deterrent factor toward the development of CoV-specific vaccines/drugs, which may serve an important role from drug design perspectives.
Journal ArticleDOI
Ecology, evolution and classification of bat coronaviruses in the aftermath of SARS.
TL;DR: It is shown that bats harbour more CoV diversity than other mammalian hosts and are widely represented in most, but not all parts of the tree of mammalian CoVs, to show the need to preserve these ecologically highly relevant animals.
Journal Article
A review of the 2019 novel coronavirus (COVID-19) based on current evidence
TL;DR: This review will introduce a general overview of coronavirus and describe the clinical features, evaluation, and treatment of COVID-19 patients and provide a means to raise awareness among primary and secondary healthcare providers during the current pandemic.
Journal ArticleDOI
Identification of myricetin and scutellarein as novel chemical inhibitors of the SARS coronavirus helicase, nsP13
Mi-Sun Yu,June Lee,Jin-Moo Lee,Younggyu Kim,Young-Won Chin,Jun-Goo Jee,Young-Sam Keum,Yong-Joo Jeong +7 more
TL;DR: This study demonstrates for the first time that selected naturally-occurring flavonoids, including myricetin and scutellarein might serve as SARS-CoV chemical inhibitors.