Combating COVID-19: The role of drug repurposing and medicinal plants
Shah Alam Khan,K. Al-Balushi +1 more
TLDR
The aim of this mini-review is to give an overview of identified repurposed anti-COVID-19 drugs which are currently under clinical trials and explore antiviral medicinal plants as adjunct or supportive therapy.About:
This article is published in Journal of Infection and Public Health.The article was published on 2021-04-01 and is currently open access. It has received 40 citations till now. The article focuses on the topics: Literature survey & Drug repositioning.read more
Citations
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Journal ArticleDOI
Discovery, Development, and Patent Trends on Molnupiravir: A Prospective Oral Treatment for COVID-19.
Mohd. Imran,Mandeep Kumar Arora,Syed Mohammed Basheeruddin Asdaq,Shah Alam Khan,Saleh I. Alaqel,Mohammed Kanan Alshammari,Mohammed M. Alshehri,Ahmed Subeh Alshrari,Alreshidi Mateq Ali,Ahmed Muteb Al-Shammeri,Bushra Dhuhayyan Alhazmi,Aishah Ali Harshan,Tauquir Alam +12 more
TL;DR: Molnupiravir as mentioned in this paper, an orally active RdRp inhibitor, is in a phase 3 clinical trial against COVID-19 and has shown good safety profile, tolerability, and oral bioavailability in humans.
Journal ArticleDOI
Recent advances on drug development and emerging therapeutic agents for Alzheimer's disease.
TL;DR: A brief review article is intended to cover the recent advances in drug development and emerging therapeutic agents for Alzheimer's disease acting at different targets as discussed by the authors, which is concluded that novel therapeutic strategies are required to discover and develop therapeutic agents to fight against the century old AD.
Journal ArticleDOI
Use of medicinal plants for COVID-19 prevention and respiratory symptom treatment during the pandemic in Cusco, Peru: A cross-sectional survey.
Magaly Villena-Tejada,Ingrid Vera-Ferchau,Anahí Cardona-Rivero,Rina Zamalloa-Cornejo,Mercedes Maritza Quispe-Flórez,Zany Frisancho-Triveno,Rosario C Abarca-Melendez,Susan G Alvarez-Sucari,Christian R. Mejia,Jaime A. Yáñez +9 more
TL;DR: In this article, a web-based cross-sectional study was conducted on general public (20-to 70-year-old) from August 31 to September 20, 2020.
Journal ArticleDOI
The find of COVID-19 vaccine: Challenges and opportunities
Marwan ElBagoury,Mahmoud M. Tolba,Hebatallah A. Nasser,Abdul Jabbar,Ahmed M. Elagouz,Yahia Aktham,Amy Hutchinson +6 more
TL;DR: Wang et al. as mentioned in this paper presented a comprehensive visualization about SARS-CoV-2 to tackle the current pandemic and concluded that vaccines formulation within exceptional no time in this pandemic is highly recommended.
Peer ReviewDOI
A Comprehensive Review of Drug Repurposing Strategies against Known Drug Targets of COVID-19
TL;DR: This review attempts to collate both the experimental and computational drug repurposing strategies that have been utilized against significant drug targets of SARS-CoV-2 and the available druggable targets shall also be discussed.
References
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Journal ArticleDOI
Inhibition of Angiotensin-Converting Enzyme Activity by Flavonoids: Structure-Activity Relationship Studies
Ligia Guerrero,Julián Castillo,Mar Quiñones,Santiago Garcia-Vallvé,Lluís Arola,Gerard Pujadas,Begoña Muguerza +6 more
TL;DR: The results suggest that flavonoids are an excellent source of functional antihypertensive products and the structure-activity relationship studies show that the combination of sub-structures on the flavonoid skeleton that increase ACEI activity is made up of the catechol group in the B-ring and the cetone group in C4 at the C-ring.
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SARS-CoV-2: Recent Reports on Antiviral Therapies Based on Lopinavir/Ritonavir, Darunavir/Umifenovir, Hydroxychloroquine, Remdesivir, Favipiravir and other Drugs for the Treatment of the New Coronavirus.
TL;DR: Since the recoveries/deaths ratio in the last weeks significantly increased, especially in China, it is clear that the experimental antiviral therapy, together with the availability of intensive care unit beds in hospitals and rigorous government control measures, all play an important role in dealing with this virus.
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In vitro antiviral activities of Caesalpinia pulcherrima and its related flavonoids.
TL;DR: The mode of action of quercetin against HSV-1 and ADV-3 was found to be at the early stage of multiplication and with SI values greater than 20, suggesting the potential use of this compound for treatment of the infection caused by these two viruses.
Journal ArticleDOI
Aminoquinolines Against Coronavirus Disease 2019 (COVID-19): Chloroquine or Hydroxychloroquine
TL;DR: This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record.
Journal ArticleDOI
Antiviral potential of curcumin
Dony Chacko Mathew,Wei-Li Hsu +1 more
TL;DR: This review summarizes the current state of knowledge with a focus on the anti-viral effect of curcumin, and their possible molecular mechanisms.