Combating COVID-19: The role of drug repurposing and medicinal plants
Shah Alam Khan,K. Al-Balushi +1 more
TLDR
The aim of this mini-review is to give an overview of identified repurposed anti-COVID-19 drugs which are currently under clinical trials and explore antiviral medicinal plants as adjunct or supportive therapy.About:
This article is published in Journal of Infection and Public Health.The article was published on 2021-04-01 and is currently open access. It has received 40 citations till now. The article focuses on the topics: Literature survey & Drug repositioning.read more
Citations
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A review of ethnobotany, phytochemistry, antimicrobial pharmacology and toxicology of Nigella sativa L.
Md. Sanower Hossain,Ashik Sharfaraz,Amit Dutta,Asif Ahsan,Md. Anwarul Masud,Idris Adewale Ahmed,Bey Hing Goh,Bey Hing Goh,Zannat Urbi,Md. Moklesur Rahman Sarker,Long Chiau Ming +10 more
TL;DR: In this paper, the authors discuss the antimicrobial pharmacology of N. sativa-based treatments and provide a holistic overview of the ethnobotany, ethnopharmacology, and phytochemistry of the plant.
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Targeting SARS-CoV-2 nsp13 Helicase and Assessment of Druggability Pockets: Identification of Two Potent Inhibitors by a Multi-Site In Silico Drug Repurposing Approach
Isabella Romeo,Francesca Alessandra Ambrosio,Giosuè Costa,Angela Corona,Mohammad Alkhatib,Romina Salpini,Saverio Lemme,Davide Vergni,Valentina Svicher,Maria Mercedes Santoro,Enzo Tramontano,Francesca Ceccherini-Silberstein,Anna Artese,Stefano Alcaro +13 more
TL;DR: In this article , a detailed conservation analysis of the SARS-CoV-2 helicase genome was performed to predict the druggable enzyme's binding pockets and a structure-based virtual screening was used to identify valuable compounds that are capable of recognizing multiple nsp13 pockets.
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Cultural belief and medicinal plants in treating COVID 19 patients of Western Colombia
TL;DR: In this paper , the authors focused on the importance of traditional, cultural and generations history with reference to the use of importance and significance of medicinal plants, especially to find out a strategy to fight the new virus.
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COVID-19 therapeutics: Clinical application of repurposed drugs and futuristic strategies for target-based drug discovery
TL;DR: In this article , the up-to-date information on target-based pharmacological classification of repurposed drugs, the potential mechanism of actions, and the current clinical trial status of various drugs which are under repurposing since early 2020 are discussed.
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Some flavolignans as potent SARS-CoV-2 inhibitors via molecular docking, molecular dynamic simulations and ADME Analysis.
TL;DR: According to the results obtained from molecular docking studies, molecular dynamic simulations, and ADME analysis, it can be proposed that the flavolignans which can be used to design effective antiviral drug candidates against the SARS-CoV-2, can be tried for promising and effective inhibitors of the SAR's main protease in vitro and in vivo studies.
References
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Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Chaolin Huang,Yeming Wang,Xingwang Li,Lili Ren,Jianping Zhao,Yi Hu,Li Zhang,Guohui Fan,Jiuyang Xu,Xiaoying Gu,Zhenshun Cheng,Ting Yu,Jia'an Xia,Yuan Wei,Wenjuan Wu,Xuelei Xie,Wen Yin,Li Hui,Min Liu,Yan Xiao,Hong Gao,Li Guo,Jungang Xie,Guang-Fa Wang,Rongmeng Jiang,Zhancheng Gao,Qi Jin,Jianwei Wang,Bin Cao +28 more
TL;DR: The epidemiological, clinical, laboratory, and radiological characteristics and treatment and clinical outcomes of patients with laboratory-confirmed 2019-nCoV infection in Wuhan, China, were reported.
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Clinical Characteristics of Coronavirus Disease 2019 in China.
Wei-jie Guan,Zhengyi Ni,Yu Hu,Wenhua Liang,Chun-Quan Ou,Jianxing He,Lei Liu,Hong Shan,Chunliang Lei,David S.C. Hui,Bin Du,Lanjuan Li,Guang Zeng,Kowk-Yung Yuen,Ruchong Chen,Chun-Li Tang,Tao Wang,Ping-Yan Chen,Jie Xiang,Shiyue Li,Jinlin Wang,Zi-jing Liang,Yi-xiang Peng,Li Wei,Yong Liu,Ya-hua Hu,Peng Peng,Jian-ming Wang,Ji-yang Liu,Zhong Chen,Gang Li,Zhi-jian Zheng,Shao-qin Qiu,Jie Luo,Chang-jiang Ye,Shao-yong Zhu,Nanshan Zhong +36 more
TL;DR: During the first 2 months of the current outbreak, Covid-19 spread rapidly throughout China and caused varying degrees of illness, and patients often presented without fever, and many did not have abnormal radiologic findings.
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Risk Factors Associated With Acute Respiratory Distress Syndrome and Death in Patients With Coronavirus Disease 2019 Pneumonia in Wuhan, China
Chaomin Wu,Xiaoyan Chen,Yanping Cai,Jia’an Xia,Xing Zhou,Sha Xu,Han-Ping Huang,Li Zhang,Xia Zhou,Chunling Du,Yuye Zhang,Juan Song,Sijiao Wang,Yencheng Chao,Zeyong Yang,Jie Xu,Xin Zhou,Dechang Chen,Weining Xiong,Lei Xu,Feng Zhou,Jinjun Jiang,Chunxue Bai,Zheng Junhua,Yuanlin Song +24 more
TL;DR: Although high fever was associated with the development of ARDS, it was also associated with better outcomes among patients with ARDS and treatment with methylprednisolone may be beneficial for patients who develop ARDS.
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Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro.
Manli Wang,Ruiyuan Cao,Leike Zhang,Xing-Lou Yang,Jia Liu,Mingyue Xu,Zhengli Shi,Zhihong Hu,Wu Zhong,Gengfu Xiao +9 more
TL;DR: This study evaluated the antiviral efficiency of five FAD-approved drugs including ribavirin, penciclovir, nitazoxanide, nafamostat, chloroquine and two well-known broad-spectrum antiviral drugs remdesivir and favipiravir against a clinical isolate of 2019-nCoV in vitro.
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First Case of 2019 Novel Coronavirus in the United States.
Michelle Holshue,Chas DeBolt,Scott Lindquist,Kathy H Lofy,John Wiesman,Hollianne Bruce,Christopher Spitters,Keith M. Marzilli Ericson,Sara Wilkerson,Ahmet Tural,George Diaz,Amanda C. Cohn,LeAnne Fox,Anita Patel,Susan I. Gerber,Lindsay Kim,Suxiang Tong,Xiaoyan Lu,Steve Lindstrom,Mark A. Pallansch,William C. Weldon,Holly M. Biggs,Timothy M. Uyeki,Satish K. Pillai +23 more
TL;DR: This case highlights the importance of close coordination between clinicians and public health authorities at the local, state, and federal levels, as well as the need for rapid dissemination of clinical information related to the care of patients with this emerging infection.