Combating COVID-19: The role of drug repurposing and medicinal plants
Shah Alam Khan,K. Al-Balushi +1 more
TLDR
The aim of this mini-review is to give an overview of identified repurposed anti-COVID-19 drugs which are currently under clinical trials and explore antiviral medicinal plants as adjunct or supportive therapy.About:
This article is published in Journal of Infection and Public Health.The article was published on 2021-04-01 and is currently open access. It has received 40 citations till now. The article focuses on the topics: Literature survey & Drug repositioning.read more
Citations
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Journal ArticleDOI
Discovery, Development, and Patent Trends on Molnupiravir: A Prospective Oral Treatment for COVID-19.
Mohd. Imran,Mandeep Kumar Arora,Syed Mohammed Basheeruddin Asdaq,Shah Alam Khan,Saleh I. Alaqel,Mohammed Kanan Alshammari,Mohammed M. Alshehri,Ahmed Subeh Alshrari,Alreshidi Mateq Ali,Ahmed Muteb Al-Shammeri,Bushra Dhuhayyan Alhazmi,Aishah Ali Harshan,Tauquir Alam +12 more
TL;DR: Molnupiravir as mentioned in this paper, an orally active RdRp inhibitor, is in a phase 3 clinical trial against COVID-19 and has shown good safety profile, tolerability, and oral bioavailability in humans.
Journal ArticleDOI
Recent advances on drug development and emerging therapeutic agents for Alzheimer's disease.
TL;DR: A brief review article is intended to cover the recent advances in drug development and emerging therapeutic agents for Alzheimer's disease acting at different targets as discussed by the authors, which is concluded that novel therapeutic strategies are required to discover and develop therapeutic agents to fight against the century old AD.
Journal ArticleDOI
Use of medicinal plants for COVID-19 prevention and respiratory symptom treatment during the pandemic in Cusco, Peru: A cross-sectional survey.
Magaly Villena-Tejada,Ingrid Vera-Ferchau,Anahí Cardona-Rivero,Rina Zamalloa-Cornejo,Mercedes Maritza Quispe-Flórez,Zany Frisancho-Triveno,Rosario C Abarca-Melendez,Susan G Alvarez-Sucari,Christian R. Mejia,Jaime A. Yáñez +9 more
TL;DR: In this article, a web-based cross-sectional study was conducted on general public (20-to 70-year-old) from August 31 to September 20, 2020.
Journal ArticleDOI
The find of COVID-19 vaccine: Challenges and opportunities
Marwan ElBagoury,Mahmoud M. Tolba,Hebatallah A. Nasser,Abdul Jabbar,Ahmed M. Elagouz,Yahia Aktham,Amy Hutchinson +6 more
TL;DR: Wang et al. as mentioned in this paper presented a comprehensive visualization about SARS-CoV-2 to tackle the current pandemic and concluded that vaccines formulation within exceptional no time in this pandemic is highly recommended.
Peer ReviewDOI
A Comprehensive Review of Drug Repurposing Strategies against Known Drug Targets of COVID-19
TL;DR: This review attempts to collate both the experimental and computational drug repurposing strategies that have been utilized against significant drug targets of SARS-CoV-2 and the available druggable targets shall also be discussed.
References
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Journal ArticleDOI
Curcumin inhibits HIV-1 by promoting Tat protein degradation.
Amjad Ali,Akhil C. Banerjea +1 more
TL;DR: A novel observation is revealed that curcumin causes potent degradation of Tat which may be one of the major mechanisms behind its anti HIV activity.
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Molecular docking, simulation and MM-PBSA studies of nigella sativa compounds: a computational quest to identify potential natural antiviral for COVID-19 treatment.
TL;DR: Compound DTQ of the present study, if validated in wet lab experiments, could be used to treat CO VID-19 and could serve as a lead in the future for development of more effective natural antivirals against COVID-19.
Journal ArticleDOI
COVID-19: emerging protective measures.
Vellingiri Balachandar,Iyer Mahalaxmi,Jayaramayya Kaavya,G Vivekanandhan,S Ajithkumar,Narayanasamy Arul,Ganesan Singaravelu,N. Senthil Kumar,S Mohana Dev +8 more
TL;DR: This work aims to develop an efficient viral inactivation system by exploiting active compounds from naturally occurring medicinal plants and infusing them into nanofiber-based respiratory masks using the compounds from medicinal plants for viral deactivation.
Journal ArticleDOI
A review on antiviral activity of the Himalayan medicinal plants traditionally used to treat bronchitis and related symptoms.
TL;DR: The aim of this review was to gather fragmented literature on ethnomedicinal plants used against bronchitis in the Himalayan region and their in‐vitro validation againstBronchitis causing viral pathogens.
Journal ArticleDOI
Antiviral activity of the infusion (SHS-174) from flowers of Sambucus nigra L., aerial parts of Hypericum perforatum L., and roots of Saponaria officinalis L. against influenza and herpes simplex viruses.
Julia Serkedjieva,Nadia Manolova,Izabella Zgórniak-Nowosielska,Barbara Zawilińska,Jan Grzybek +4 more
TL;DR: The SHS‐174 preparation, a lyophilized infusion from flowers of Sambucus nigra L., aerial parts of Hypericum perforatum L., and roots of Saponaria officinalis exhibited an antiviral effect and inhibited the reproduction of different strains of influenza virus types A and B, both in vitro and in vivo, and herpes simplex virus type 1, in vitro.