Common Carotid Intima-Media Thickness and Arterial Stiffness Indicators of Cardiovascular Risk in High-Risk Patients The SMART Study (Second Manifestations of ARTerial disease)
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TLDR
Common carotid IMT anddistensibility are clear markers of cardiovascular risk in patients who already have vascular disease or atherosclerotic risk factors and IMT appears to discriminate between low- and high-risk patients better than distensibility.Abstract:
Background—Common carotid intima-media thickness (IMT) and distensibility are markers of structural and functional vessel wall properties. Both parameters have been found in population-based studies to be associated with cardiovascular risk factors and prevalent cardiovascular disease. We investigated cross-sectionally whether IMT and distensibility are associated with cardiovascular risk in patients who already have vascular disease or atherosclerotic risk factors and evaluated the diagnostic ability of IMT and distensibility to discriminate between low- and high-risk patients. Methods and Results—IMT and distensibility (change of diameter) of the left and right common carotid arteries were measured in the first 570 patients (537 for distensibility) enrolled in the Second Manifestations of ARTerial disease (SMART) study, a cohort study among patients with a manifestation of vascular disease or cardiovascular risk factors. Three risk scores were used to classify each patient’s vascular risk. Areas under t...read more
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