Common Developmental Requirement for Olig Function Indicates a Motor Neuron/Oligodendrocyte Connection
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TLDR
Targeted disruption of Olig1 and Olig2 genes sheds light on the ontogeny of oligodendroglia and genetic requirements for their development from multipotent CNS progenitors, indicating that oligod endodendrocytes are derived from Olig-specified progenitor that give rise also to neurons.About:
This article is published in Cell.The article was published on 2002-04-05 and is currently open access. It has received 1006 citations till now. The article focuses on the topics: Oligodendrocyte Transcription Factor 2 & OLIG2.read more
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Principles of Neural Science
TL;DR: The editors have done a masterful job of weaving together the biologic, the behavioral, and the clinical sciences into a single tapestry in which everyone from the molecular biologist to the practicing psychiatrist can find and appreciate his or her own research.
Journal ArticleDOI
Directed Differentiation of Embryonic Stem Cells into Motor Neurons
TL;DR: It is shown that developmentally relevant signaling factors can induce mouse embryonic stem cells to differentiate into spinal progenitor cells, and subsequently into motor neurons, through a pathway recapitulating that used in vivo.
Journal ArticleDOI
Proneural genes and the specification of neural cell types
TL;DR: Parallel studies in Drosophila and vertebrates have revealed that proneural genes are key regulators of neurogenesis, coordinating the acquisition of a generic neuronal fate and of specific subtype identities that are appropriate for the location and time of neuronal generation.
Journal ArticleDOI
The bHLH Transcription Factors OLIG2 and OLIG1 Couple Neuronal and Glial Subtype Specification
Qiao Zhou,David J. Anderson +1 more
TL;DR: The results suggest that in the spinal cord, Olig and proneural genes comprise a combinatorial code for the specification of neurons, astrocytes, and oligodendroCytes, the three fundamental cell types of the central nervous system.
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Competing waves of oligodendrocytes in the forebrain and postnatal elimination of an embryonic lineage.
Nicoletta Kessaris,Matthew Fogarty,Palma Iannarelli,Matthew Grist,Michael Wegner,William D. Richardson +5 more
TL;DR: It is shown, by Cre-lox fate mapping in transgenic mice, that the first OLPs originate in the medial ganglionic eminence (MGE) and anterior entopeduncular area (AEP) in the ventral forebrain, and that functionally redundant populations of OLPs compete for space in the developing brain.
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Principles of Neural Science
TL;DR: The principles of neural science as mentioned in this paper have been used in neural networks for the purpose of neural network engineering and neural networks have been applied in the field of neural networks, such as:
Journal ArticleDOI
Principles of Neural Science
TL;DR: The editors have done a masterful job of weaving together the biologic, the behavioral, and the clinical sciences into a single tapestry in which everyone from the molecular biologist to the practicing psychiatrist can find and appreciate his or her own research.
Journal ArticleDOI
Neuronal specification in the spinal cord: inductive signals and transcriptional codes
TL;DR: The mechanisms that specify the identity of neural cells have been examined in many regions of the nervous system and reveal a high degree of conservation in the specification of cell fate by key signalling molecules.
PatentDOI
A homeodomain protein code specifying progenitor cell identity and neuronal fate in the ventral neural tube
TL;DR: Cross-repressive interactions between class I and class II proteins appear to refine and maintain these progenitor domains, which generate a distinct class of postmitotic neurons in the ventral third of the neural tube.
Related Papers (5)
The bHLH Transcription Factors OLIG2 and OLIG1 Couple Neuronal and Glial Subtype Specification
Qiao Zhou,David J. Anderson +1 more