Comparative analysis of human matrix metalloproteinases: Emerging therapeutic targets in diseases.
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TLDR
It is hypothesize that cysteine rich and highly thermostable MMPs might be key players in diseased conditions and a plausible grouping of disease responsive M MPs that might be considered as promising clinical targets may be done.Abstract:
The identification of specific target proteins for any diseased condition involves extensive characterization of the potentially involved proteins. Members of a protein family demonstrating comparable features may show certain unusual features when implicated in a pathological condition. Advancements in the field of computational biology and the use of various bioinformatics tools for analysis can aid researchers to comprehend their system of work in primary stages of research. This initial screening can help to reduce time and cost of testing and experimentation in laboratory. Human matrix metalloproteinase (MMP) family of endopeptidases is one such family of 23 members responsible for the remodeling of extracellular matrix (ECM) by degradation of the ECM proteins. Though their role has been implicated in various pathological conditions such as arthritis, atherosclerosis, cancer, liver fibrosis, cardio-vascular and neurodegenerative disorders, little is known about the specific involvement of members of the large MMP family in diseases. A comparative in silico characterization of the MMP protein family has been carried out to analyze their physico-chemical, secondary structural and functional properties. Based on the observed patterns of occurrence of atypical features, we hypothesize that cysteine rich and highly thermostable MMPs might be key players in diseased conditions. Thus, a plausible grouping of disease responsive MMPs that might be considered as promising clinical targets may be done. This study can be used as a fundamental approach to characterize, analyze and screen large protein families for the identification of signature patterns.read more
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Study of the Correlations among Some Parameters of the Oxidative Status, Gelatinases, and Their Inhibitors in a Group of Subjects with Metabolic Syndrome
TL;DR: In MS subjects a prooxidant status and increased levels of gelatinases and their inhibitors are evident although the correlations between oxidative stress and MMPs or TIMPs are controversial and need further investigation.
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Extracellular Matrix Remodeling of Adipose Tissue in Obesity and Metabolic Diseases
TL;DR: This review is focused at identifying the putative role of ECM in adipose tissue, describing its structure and components, its main tissue receptors, and how it is affected in obesity, and subsequently the importance of an appropriate ECM remodeling in adiposes tissue expansion to prevent metabolic diseases.
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Intricate functions of matrix metalloproteinases in physiological and pathological conditions
Rahul Mittal,Amit P. Patel,Luca H. Debs,Desiree Nguyen,Kunal Patel,M'hamed Grati,Jeenu Mittal,Denise Yan,Prem P. Chapagain,Xue Zhong Liu +9 more
TL;DR: A review article summarized the recent advances in understanding the role of MMPs in physiological and pathological conditions and suggested drugs specifically targeting individual M MPs could revolutionize the treatment of a great number of health conditions and tremendously reduce their burden.
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Matrix metalloproteinases in metabolic syndrome
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TL;DR: The evidences of an improvement in MMP/TIMP ratio with diet, exercise and medical therapy should encourage further investigations with the intent to contrast the atherosclerotic process and to reduce morbidity and mortality of this kind of patients.
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References
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ExPASy: The proteomics server for in-depth protein knowledge and analysis.
Elisabeth Gasteiger,Alexandre Gattiker,Christine Hoogland,Ivan Ivanyi,Ron D. Appel,Amos Marc Bairoch +5 more
TL;DR: The ExPASy (the Expert Protein Analysis System) World Wide Web server, provided as a service to the life science community by a multidisciplinary team at the Swiss Institute of Bioinformatics, provides access to a variety of databases and analytical tools dedicated to proteins and proteomics.
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