Journal ArticleDOI
Comparative effects of palm vitamin E and α-tocopherol on healing and wound tissue antioxidant enzyme levels in diabetic rats
M Musalmah,M. Y. Nizrana,A. H. M. Fairuz,A. H. NoorAini,A. L. Azian,M. T. Gapor,Wan Zurinah Wan Ngah +6 more
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TLDR
Results showed that PVE had a greater potency to enhance wound repair and induce the increase in free radical-scavenging enzyme activities than α-Toc, which were potent antioxidants and significantly reduced the lipid peroxidation levels in the wounds as measured by the reduction in MDA levels.Abstract:
The effect of supplementing 200 mg/kg body weight palm vitamin E (PVE) and 200 mg/kg body weight α-tocopherol (α-loc) on the healing of wounds in streptozotocin-induced diabetic rats was evaluated. The antioxidant potencies of these two preparations of vitamin E were also evaluated by determining the antioxidant enzyme activities, namely, glutathione peroxidase (GPx) and superoxide dismutase (SOD), and malondialdehyde (MDA) levels in the healing of dermal wounds. Healing was evaluated by measuring wound contractions and protein contents in the healing wounds. Cellular redistribution and collagen deposition were assessed morphologically using cross-sections of paraffin-embedded day-10 wounds stained according to the Van Gieson method. GPx and SOD activities as well as MDA levels were determined in homogenates of day-10 dermal wounds. Results showed that PVE had a greater potency to enhance wound repair and induce the increase in free radical-scavenging enzyme activities than α-Toc. Both PVE and α-Toc, however, were potent antioxidants and significantly reduced the lipid peroxidation levels in the wounds as measured by the reduction in MDA levels.read more
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Oxidative stress in normal and impaired wound repair
Matthias Schäfer,Sabine Werner +1 more
TL;DR: This review summarizes the current information about the roles of low molecular weight antioxidants and ROS-detoxifying enzymes in normal and impaired wound repair, and reports on the consequences of their modulation at the wound site.
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Wound Healing Properties of Selected Natural Products.
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Antioxidant therapies for wound healing: a clinical guide to currently commercially available products.
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TL;DR: Both the extracts of plantain banana showed good safety profile and favoured wound healing which could be due to its antioxidant effect and on various wound healing biochemical parameters.
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Xing-Tai Li,Ya-Kui Zhang,Hai-Xue Kuang,Feng-Xin Jin,De-Wen Liu,Ming-Bo Gao,Ze Liu,Xiao-Juan Xin +7 more
TL;DR: According to this research, Astragalus polysaccharides protects mitochondria by scavenging reactive oxygen species (ROS), inhibiting mitochondrial PT and increasing the activities of antioxidases, which has the effect of promoting health.
References
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TL;DR: D-Alpha-tocotrienol possesses 40-60 times higher antioxidant activity against (Fe2+ + ascorbate)- and (Fe1+ + NADPH)-induced lipid peroxidation in rat liver microsomal membranes and 6.5 times better protection of cytochrome P-450 against oxidative damage than d-alpha-tocopherol.
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