Showing papers in "Clinica Chimica Acta in 1986"

TL;DR: A positive correlation between the lipid peroxide concentration and other investigated components in plasma and between the triglycerides, cholesterol, total lipids and lipid peroxides in patients with atherosclerotic lesions of peripheral arteries and in the arterial wall was found.

TL;DR: A capillary gas chromatographic method for the profiling of trimethylsilylated mono- and disaccharides and polyols in urine, plasma and unwashed and washed erythrocytes is described, and quantitative data obtained from urines of pediatric patients with galactosemia and a neurological disorder with a high calorie gastric drip feeding are presented and discussed.

TL;DR: It is concluded that the chimpanzee excretes both isoflavonic phytoestrogens and lignans in urine, apparently in high concentrations, and it is suggested that these compounds may play a role in the maintenance of the resistance against carcinogenic effects of estrogens.

TL;DR: The nervous system specific proteins glial fibrillary acidic protein (GFAp), S-100 and myelin basic protein (MBP) were determined in 535 human cerebrospinal fluid (CSF) samples and it was suggested that GFAp is to be considered as a specific marker of fibrilla gliosis in CSF and can be used as a diagnostic tool in dementia and syringomyelia.

TL;DR: Assay procedures are described for the detection of defects in the process of NADH oxidation by the respiratory chain in human skeletal muscle biopsy specimens and the use of ferricyanide as electron acceptor for estimation of NADh dehydrogenase activity is inadequate when only applied on a disrupted mitochondrial preparation.

TL;DR: The major circulating antioxidant protein, caeruloplasmin (CP), was significantly increased by 25-30% in DMD patients compared with both adult and young male controls suggesting that increased LPX may be a trigger for CP synthesis.

TL;DR: A sandwich enzyme immunoassay for epidermal growth factor (EGF) has been developed which measures EGF concentrations in serum, urine, saliva, gastric and pancreatic juices without pretreatment, suggesting that EGF promotes cell proliferation during growth.

TL;DR: The concentration of conjugated bile acids became significantly elevated 30, and 60 min after a standard meal, whereas that of unconjugated biles acids remained unchanged in jejunal fluid.

TL;DR: A linear correlation (r = 0.92; p less than 0.001) was found between plasma oxalate and plasma creatinine in patients with chronic renal failure, thus indicating a net tubular secretion of oxalates.

TL;DR: The low level in serum compared to the high urinary excretion of NAA suggests the possibility that NAA is synthesized in the kidneys in addition to the brain, and may cast new light on the functional role of N-acetylaspartic acid in humans.

TL;DR: In samples from normal infants and children bile salt peaks were rarely detectable above the background whereas peaks produced by steroid sulphates and glucuronides and bile alcohol glucuronide could usually be identified.

TL;DR: A simple and reliable method for determination of total HDL, HDL2, and HDL3 by a precipitation technique using dextran-sulfate (Mr 50,000)-Mg2+.

TL;DR: Microalbuminuria, (relative albumin clearance) detected by means of a sensitive, specific immunochemical method was a more discriminatory diagnostic test in pre-eclampsia than the customary test strip reaction for clinical proteinuria.

TL;DR: This ELISA, although among the most sensitive immunoassays for human proinsulin, is still not sensitive enough to measure the concentrations expected in samples from IDDM patients in the fasting state, but the method is useful in characterising beta-cell function in stimulated situations, as well as in the diagnosis of insulinoma.

TL;DR: The lithogenic and inhibitory substances in the 24-h urine of 150 healthy females and 150 healthy males were recorded and all the parameters measured with respect to the males displayed higher levels of excretion than those of the females.

TL;DR: Neither vitamin D3 nor 25-hydroxyvitamin D3 were found in tissues of vitamin D-deficient rats using this method, and 25-Hydroxyv Vitamin D3 could not be detected in adipose tissue and very little was found in muscle of normal rats.

TL;DR: The results suggest that patients suffering from cholesterol gallstones have a reduced ability to esterify potentially harmful free cholesterol compared with controls and support the proposition that cholesterol gallstone formation is related to altered hepatic cholesterol metabolism.

TL;DR: An original assay is developed which allows measurement of the overall peroxisomal beta-oxidation activity in human liver homogenates and shows a strong deficiency of this activity was detected in liver from Zellweger patients using palmitoyl-CoA as a substrate.

TL;DR: The data suggest laminin as a potentially useful parameter for monitoring the portal venous pressure in cirrhotic and severe fibrotic patients.

TL;DR: The concentrations of guanidino compounds in blood are raised in uraemic patients and may have toxic effects; however, the values obtained for taurocyamine and beta-guanidinoproprionic acid were much lower than those reported by others.

TL;DR: Multiple stepwise regression analyses identified the combination of neopterin, hematocrit, weekly stool frequency, palpable abdominal mass and related symptoms as predicting clinical activity better than Crohn's Disease Activity Index (CDAI).

TL;DR: It was found that the most pronounced inhibition was obtained with the polyanions with the highest charge density, i.e., heparin and pentosan polysulphate.

TL;DR: At the inhibitory pH at 25 degrees C, the glucose content did not decrease over a period of 8 h, but it did decrease by 1.3 +/- 1.1 mg/dl over 24 h.

TL;DR: It is concluded that CA 125 is a non-specific marker of ascites whatever the origin: ovarian carcinoma, cirrhosis or peritoneal inflammatory process.

TL;DR: It is now rather more than 25 years since the idea that, within a single organism, the same chemical reaction may be catalysed by several structurally distinct enzyme proteins became accepted as a major generalization in biochemistry.

TL;DR: The data indicate that increased levels of very-long-chain fatty acids in Zellweger syndrome are due to the lack of the enzyme proteins of peroxisomal beta-oxidation.

TL;DR: Patients with inherited adenylosuccinase deficiency excrete large quantities of succinyloaminoimidazolecarboxamide riboside (SAICAR) and succinyloadenosine (SAdo) and their concentrations are determined by cation exchange column chromatography.

TL;DR: New methods for the estimation of red cell gamma-glutamylcysteine Synthetase and glutathione synthetase have been developed and normal values are presented.

TL;DR: The inter-assay reproducibility of the HDL-cholesterol determination after phosphotungstic acid/MgCl2 precipitation and subsequent LDL-ch cholesterol quantification according to Friedewald was statistically equivalent to that of ultracentrifugation, whereas the quantitative lipoprotein electrophoresis proved less precise.

TL;DR: A precise and easy method for measuring glycated serum albumin using affinity chromatography and immunoturbidimetry on a centrifugal analyser, ensuring complete recovery of serumalbumin is described.