Journal ArticleDOI
Comparative study on the binding of estrogens by human and rat serum proteins in development
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TLDR
The adult human and particularly the female at the end of pregnancy, display a serum sex binding globulin with high affinity for both 17β-estradiol and testosterone.About:
This article is published in Biochemical and Biophysical Research Communications.The article was published on 1974-03-15. It has received 76 citations till now. The article focuses on the topics: Blood proteins & Estrone.read more
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The potential roles of estrogens in regulating Leydig cell development and function: a review.
TL;DR: The net biologic effect of estradiol in the testis appears to be inhibition of androgen production, either by limiting development and growth of the Leydig cell population or through direct action in the LeYDig cell.
Journal ArticleDOI
A molecular basis for estrogen-induced cryptorchidism
TL;DR: It is shown that maternal exposure to estrogens, including 17alpha- and beta-estradiol, as well as DES, specifically down regulates Insl3 expression in embryonic Leydig cells, thereby providing a mechanism for cryptorchidism.
Journal ArticleDOI
Alpha-fetoprotein: a review.
TL;DR: Maternal serum AFP measurement can be used as a screening procedure to identify neural tube defects providing a rigorous protocol is followed and a reliable assay with adequate controls is employed.
References
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Journal Article
Protein Measurement with the Folin Phenol Reagent
TL;DR: Procedures are described for measuring protein in solution or after precipitation with acids or other agents, and for the determination of as little as 0.2 gamma of protein.
Journal ArticleDOI
Immunochemical quantitation of antigens by single radial immunodiffusion
TL;DR: By standardizing the technical conditions of the experiment it is possible to use this principle for the immunochemical determination of antigens, and the lower limit of the method was found to correspond to 0·0025 μg of antigen, and to an antigen concentrations of 1·25 μg per ml.
Journal ArticleDOI
Steroid-protein interaction with particular reference to testosterone binding by human serum.
William H. Pearlman,Odette Crépy +1 more
TL;DR: A sensitive and rapid method for the detection and quantitative estimation of serum protein, or proteins, exhibiting a specific or high binding affinity for testosterone may also prove to be useful in the general study of steroid-protein interaction.
Journal ArticleDOI
Occurrence of fetoprotein in patients with neoplasms and non-neoplastic diseases
TL;DR: The results show that fetoprotein appears in two types of tumors only: 1) in hepatocellular carcinoma, and 2) in malignant undifferentiated teratoma.
Journal ArticleDOI
Estrogen-binding properties of rat, mouse and man fetospecific serum proteins. Demonstration by immuno-autoradiographic methods.
TL;DR: The results obtained strongly support the conclusion that the high estrogen-ligand properties of sera from embryos and new born rats and of rat and human pregnancy plasma are, at least in part, due to the presence of this feto-specific protein.
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Steroid-protein interaction with particular reference to testosterone binding by human serum.
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