Journal ArticleDOI
Comparison of 4-class and continuous fat/water methods for whole-body, MR-based PET attenuation correction
Scott David Wollenweber,Sonal Ambwani,Albert Henry Roger Lonn,Dattesh Dayanand Shanbhag,Sheshadri Thiruvenkadam,Sandeep Kaushik,Rakesh Mullick,Florian Wiesinger,Hua Qian,Gaspar Delso +9 more
- Vol. 60, Iss: 5, pp 3391-3398
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TLDR
It is demonstrated that both 4class and continuousFat/water AC methods provided adequate quantitation in the body, and that the continuous fat/water method was within 5.7% on average for SUV mean in liver and 1.6% onaverage for SUV max for FDG-avid features.Abstract:
The goal of this study was to compare two approaches for MR-based PET patient attenuation correction (AC) in whole-body FDG-PET imaging using a tri-modality PET/CT & MR setup. Sixteen clinical whole-body FDG patients were included in this study. Mean standard uptake values (SUV) were measured for liver and lung volumes-of-interest for comparison. Maximum SUV values were measured in 18 FDGavid features in ten of the patients. The AC methods compared to gold-standard CT-based AC were segmentation of the CT (air, lung, fat, water), MR image segmentation with 4 tissue classes (air, lung, fat, water) and segmentation with air, lung and a continuous fat/water method. Results: The magnitude of uptake value differences induced by CT-based image segmentation were similar but lower on average than those found using the MRderived AC methods. The average liver SUV difference with that found using CTAC was 1.3%, 10.4% and 5.7% for 4-class segmented CT, 4-class MRAC and continuous fat/water MRAC methods, respectively. The average FDG-avid feature SUV max difference was -0.5%,1.7% and -1.6% for 4-class segmented CT, 4-class MRAC and continuous fat/water MRAC methods, respectively. Conclusion: The results demonstrated that both 4class and continuous fat/water AC methods provided adequate quantitation in the body, and that the continuous fat/water method was within 5.7% on average for SUV mean in liver and 1.6% on average for SUV max for FDG-avid features.read more
Citations
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Journal ArticleDOI
Zero-Echo-Time and Dixon Deep Pseudo-CT (ZeDD CT): Direct Generation of Pseudo-CT Images for Pelvic PET/MRI Attenuation Correction Using Deep Convolutional Neural Networks with Multiparametric MRI
Andrew P. Leynes,Andrew P. Leynes,Jaewon Yang,Florian Wiesinger,Sandeep Kaushik,Dattesh Dayanand Shanbhag,Youngho Seo,Youngho Seo,Thomas A. Hope,Thomas A. Hope,Peder E. Z. Larson,Peder E. Z. Larson +11 more
TL;DR: ZeDD CT produces natural-looking and quantitatively accurate pseudo-CT images and reduces error in pelvic PET/MRI attenuation correction compared with standard methods.
Journal ArticleDOI
NEMA NU 2-2012 performance studies for the SiPM-based ToF-PET component of the GE SIGNA PET/MR system.
Alexander M. Grant,Timothy Deller,Mohammad Mehdi Khalighi,Sri Harsha Maramraju,Gaspar Delso,Craig S. Levin +5 more
TL;DR: Performance measurements of the ToF-PET whole body GE SIGNA PET/MR system indicate that it is a promising new simultaneous imaging platform.
Journal ArticleDOI
PET/MRI: Where might it replace PET/CT?
Eric C. Ehman,Geoffrey B. Johnson,Javier Villanueva-Meyer,Soonmee Cha,Andrew P. Leynes,Peder E. Z. Larson,Thomas A. Hope +6 more
TL;DR: It is hoped that future work will prove the benefit of PET/MRI to specific groups of patients, initially those in which PET/CT and MRI are already performed, leveraging simultaneity and allowing for greater degrees of multiparametric evaluation.
Journal ArticleDOI
68Ga-PSMA-11 PET Imaging of Response to Androgen Receptor Inhibition: First Human Experience.
Thomas A. Hope,Thomas A. Hope,Charles Truillet,Eric C. Ehman,Ali Afshar-Oromieh,Rahul Aggarwal,Charles J. Ryan,Peter R. Carroll,Eric J. Small,Michael J. Evans +9 more
TL;DR: Inhibition of the AR can increase PSMA expression in prostate cancer metastases and increase the number of lesions visualized using PSMA PET in a mouse xenograft model and a patient with castration-sensitive prostate cancer.
Journal ArticleDOI
Design Features and Mutual Compatibility Studies of the Time-of-Flight PET Capable GE SIGNA PET/MR System
Craig S. Levin,Sri Harsha Maramraju,Mohammad Mehdi Khalighi,Timothy Deller,Gaspar Delso,Floris Jansen +5 more
TL;DR: A whole body hybrid PET/MR system capable of simultaneous acquisition of both time-of-flight (TOF) PET and high resolution MR data and impact of PET on MR IQ was assessed by comparing SNR with PET acquisition on and off.
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