Journal ArticleDOI
Concerted regulation of cardiac sarcoplasmic reticulum calcium transport by cyclic adenosine monophosphate dependent and calcium--calmodulin-dependent phosphorylations.
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This article is published in Biochemistry.The article was published on 1979-11-13. It has received 432 citations till now. The article focuses on the topics: Ryanodine receptor 2 & Cyclic adenosine monophosphate.read more
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The role of protein phosphorylation in neural and hormonal control of cellular activity
TL;DR: There is an integrated network of regulatory pathways, mediated by phosphorylation–dephosphorylation, that allows diverse cellular events to be coordinated by neural and hormonal stimuli, and the evidence that supports this concept is reviewed.
Journal ArticleDOI
Calmodulin—an intracellular calcium receptor
Anthony R. Means,John R. Dedman +1 more
TL;DR: Calmodulin, a protein that binds calcium with high affinity and specificity, is structurally conserved and functionally preserved throughout the animal and plant kingdoms.
Journal Article
Increased accumulation of vincristine and adriamycin in drug-resistant P388 tumor cells following incubation with calcium antagonists and calmodulin inhibitors
TL;DR: The high intracellular drug accumulation was directly related to the enhancement of the cytotoxicity of the antitumor agents, and the vincristine and Adriamycin resistance in these cells was circumvented.
Journal ArticleDOI
Phospholamban: Protein Structure, Mechanism of Action, and Role in Cardiac Function
TL;DR: A comprehensive discussion is presented of advances in understanding the structure and function of phospholamban, the principal regulator of the Ca2+-ATPase of cardiac sarcoplasmic reticulum.
Journal ArticleDOI
Calcium/calmodulin-dependent protein kinase II.
Roger J. Colbran,C. M. Schworer,Y Hashimoto,Y. L. Fong,D. P. Rich,M K Smith,Thomas R. Soderling +6 more
TL;DR: The chapter summarizes the present knowledge of CaM kinase II with the particular emphasis on the molecular mechanisms involved in the regulation of kinase activity, and reviews the literature concerning the putative physiological functions of the kinase.
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Journal Article
Protein Measurement with the Folin Phenol Reagent
TL;DR: Procedures are described for measuring protein in solution or after precipitation with acids or other agents, and for the determination of as little as 0.2 gamma of protein.
Journal ArticleDOI
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
TL;DR: Using an improved method of gel electrophoresis, many hitherto unknown proteins have been found in bacteriophage T4 and some of these have been identified with specific gene products.
Journal Article
Cleavage of structural proteins during the assemble of the head of bacterio-phage T4
TL;DR: Using an improved method of gel electrophoresis, many hitherto unknown proteins have been found in bacteriophage T4 and some of these have been identified with specific gene products as mentioned in this paper.
Journal ArticleDOI
Preparation of Iodine-131 Labelled Human Growth Hormone of High Specific Activity
W M Hunter,F. C. Greenwood +1 more
TL;DR: Current procedures for the immunological assay of protein hormones in human plasma require the routine preparation of hormones labelled with iodine-131 of high specific activity, and this work demonstrates the importance of knowing the carrier and removal status of iodine.
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A simple method for the preparation of 32P-labelled adenosine triphosphate of high specific activity
IM Glynn,JB Chappell +1 more
TL;DR: Hydrolysis of the labeled ATP with heavy meromyosin indicates that 98 to 99% of the /sup 32/P is in the 1 -phosphate group.