Journal ArticleDOI
Controls of hair follicle cycling.
Kurt S. Stenn,Ralf Paus +1 more
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TLDR
This review has used Chase as the model and tried to put the adult hair follicle growth cycle in perspective, and hopes that this work will serve as an introduction to basic biologists who are looking for a defined biological system that illustrates many of the challenges of modern biology.Abstract:
Nearly 50 years ago, Chase published a review of hair cycling in which he detailed hair growth in the mouse and integrated hair biology with the biology of his day. In this review we have used Chas...read more
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Journal ArticleDOI
Stem cells find their niche
TL;DR: Technical advances now make it possible to characterize small zones that maintain and control stem cell activity in several organs, including gonads, skin and gut, and promise to advance efforts to use stem cells therapeutically.
Journal ArticleDOI
The biology of hair follicles.
Ralf Paus,George Cotsarelis +1 more
TL;DR: Progress in understanding of the biology and pathology of hair follicles should lead to more effective therapies for disorders of hair growth, and few drugs that are effective for these purposes are available.
Journal ArticleDOI
A comprehensive guide for the accurate classification of murine hair follicles in distinct hair cycle stages.
Sven Müller-Röver,Bori Handjiski,Carina van der Veen,Stefan B. Eichmüller,Kerstin Foitzik,Ian A. McKay,Kurt S. Stenn,Ralf Paus +7 more
TL;DR: This guide should become a useful tool when screening new mouse mutants or mice treated with pharmaceuticals for discrete morphologic abnormalities of hair follicle cycling in a highly reproducible, easily applicable, and quantifiable manner.
Journal ArticleDOI
Diversity, topographic differentiation, and positional memory in human fibroblasts
Howard Y. Chang,Jen-Tsan Chi,Sandrine Dudoit,Chanda Bondre,Matt van de Rijn,David Botstein,Patrick O. Brown +6 more
TL;DR: Cultured fetal and adult human fibroblasts maintained key features of HOX gene expression patterns established during embryogenesis, suggesting that HOX genes may direct topographic differentiation and underlie the detailed positional memory in fibro Blasts.
Book ChapterDOI
Developmental roles and clinical significance of hedgehog signaling.
TL;DR: This review focuses on the developing systems themselves, providing a comprehensive survey of the role of Hedgehog signaling in each of these, and the increasing significance of Hedge Hog signaling in the clinical setting.
References
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Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.
TL;DR: The extent of tissue-PCD revealed by this method is considerably greater than apoptosis detected by nuclear morphology, and thus opens the way for a variety of studies.
Journal ArticleDOI
Patterns and Emerging Mechanisms of the Angiogenic Switch during Tumorigenesis
TL;DR: The work from the authors' laboratories reviewed herein was supported by grants from the National Cancer Institute.
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The Bcl-2 Protein Family: Arbiters of Cell Survival
Jerry M. Adams,Suzanne Cory +1 more
TL;DR: Bcl-2 and related cytoplasmic proteins are key regulators of apoptosis, the cell suicide program critical for development, tissue homeostasis, and protection against pathogens.
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Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation
TL;DR: It is shown here that this morphological change is closely associated with excision of nucleosome chains from nuclear chromatin, apparently through activation of an intracellular, but non-lysosomal, endonuclease.