Journal ArticleDOI
Convenient synthesis of 2-thionaphthylmethyl isocyanide: a useful reagent for methyl isocyanide transfer
TLDR
The 2-thionaphthylmethyl isocyanide (2-THIOCYANIDE) as discussed by the authors, which is derived from the novel N-(formamidomethyl)-N-benzyl morpholinium iodide (N-BNI) via transfer of elements of CH 2 NHCHO, is totally devoid of pervasive odour.About:
This article is published in Tetrahedron Letters.The article was published on 1988-01-01. It has received 8 citations till now. The article focuses on the topics: Methyl isocyanide & Isocyanide.read more
Citations
More filters
Journal ArticleDOI
Alkylation of amino acids and glutathione in water by o-quinone methide. Reactivity and selectivity.
TL;DR: These are the first direct reaction rate measurements of nucleophilic addition to the parent o-quinone methide, and a thermal and photochemical reversibility of the alkylation process opens a new perspective for the use and application of such adducts as o-QM molecular carriers.
Journal ArticleDOI
Asmic: An Exceptional Building Block for Isocyanide Alkylations.
Embarek Alwedi,J. Armando Lujan-Montelongo,Bhaskar Reddy Pitta,Allen Chao,Rodrigo Cortés-Mejía,Jorge M. del Campo,Fraser F. Fleming +6 more
TL;DR: The o-anisylsulfanyl group serves a critical dual role by facilitating deprotonation-alkylation and providing a latent nucleophilic site through an unusual arylsulfanyl-lithium exchange.
Journal ArticleDOI
Oxazole Synthesis by Sequential Asmic-Ester Condensations and Sulfanyl-Lithium Exchange-Trapping.
TL;DR: In this article, Oxazoles are rapidly assembled through a sequential deprotonation-condensation of Asmic, anisylsulfanylmethylisocyanide, with esters followed by sulfanyl-lithium exchange-trapping Deprotonating As.
Patent
Process for the synthesis of imidazoles
TL;DR: In this article, a process for the preparation of imidazoles by reacting a cyano compound with a silylalkylisocyanide compound was described, which are useful pharmacologically-active compounds and/or intermediates for the synthesis of pharmacologically active compounds.
References
More filters
Journal ArticleDOI
Condensation of Naphthols with Formaldehyde and Primary Amines1
Journal Article
Chemistry of sulfonylmethyl isocyanides .22. synthesis of (+)-(neomenthylsulfonyl)methyl isocyanide - synthesis and absolute-configuration of (r)-(+)-2-methylcyclobutanone and (s)-(-)-2-methylcyclobutanone
Journal ArticleDOI
Über Darstellung und Umsetzungen von Formamidomethyl-aminen, -sulfiden und -sulfonen
Horst Böhme,Günter Fuchs +1 more
TL;DR: In this article, the authors describe the preparation and reaction of (formamidomethyl)amines, sulfides, and -sulfones using formaldehyde and secondary amines.
Journal ArticleDOI
Synthesis of 1‐(arylthio)alkenyl isocyanides
TL;DR: In this paper, a series of (Z)- and/or (E)-1-(arylthio)alkenyl isocyanides (1, 2) was synthesized in good yields from (arylthios)methyl isocynides (4) and either aldehydes or ketones via a Peterson olefination using silylated 4 as intermediates.
Related Papers (5)
Synthesis of α-Arylated Phenylsulfonylacetonitriles. A Useful Precursor for Substituted α-Arylalkanoic Acid and Their Derivatives
An efficient synthesis of 2-chloro-3-carboethoxy- or 2-chloro-3-cyano- 4,5-disubstituted and 5-substituted pyrroles
Louise H. Foley,Louise H. Foley +1 more