Journal ArticleDOI
Corneal Penetration Behavior of β-Blocking Agents I: Physicochemical Factors
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In this article, rabbit corneas were excised and mounted in a chamber to determine the permeability characteristics of a group of beta-blocking agents which varied in octanol-water partitioning over a fourfold logarithmic range.About:
This article is published in Journal of Pharmaceutical Sciences.The article was published on 1983-11-01. It has received 390 citations till now. The article focuses on the topics: Correlation coefficient.read more
Citations
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Epithelial Transport Of Drugs In Cell Culture. I: A Model For Studying The Passive Diffusion Of Drugs Over Intestinal Absorbtive (Caco-2) Cells
TL;DR: The findings of this paper indicate that Caco-2 cells may be used to model the intestinal absorption of drugs.
Journal ArticleDOI
Ophthalmic drug delivery systems—Recent advances
TL;DR: In this paper, the authors focus on three representative areas of ophthalmic drug delivery systems: polymeric gels, colloidal systems, cyclodextrins and collagen shields.
Journal ArticleDOI
Permeability of cornea, sclera, and conjunctiva: A literature analysis for drug delivery to the eye
TL;DR: A comprehensive database of ocular tissue permeability measurements found in a review of the literature to guide models for drug transport in the eye was collected and the corneal epithelium was shown generally to control transcorneal transport.
Journal ArticleDOI
Topical Ocular Drug Delivery: Recent Developments and Future Challenges
TL;DR: The focus of this review is on recent developments in topical ocular drug delivery systems relative to their success in overcoming the constraints imposed by the eye and to the improvements that have yet to be made.
Journal ArticleDOI
Pharmacokinetic aspects of retinal drug delivery.
Eva M. del Amo,Anna-Kaisa Rimpelä,Emma M. Heikkinen,Otto K. Kari,Eva Ramsay,Tatu Lajunen,Mechthild Schmitt,Laura Pelkonen,Madhushree Bhattacharya,Dominique Richardson,Astrid Subrizi,Tiina Turunen,Mika Reinisalo,Jaakko Itkonen,Elisa Toropainen,Marco G. Casteleijn,Heidi Kidron,Maxim Antopolsky,Kati-Sisko Vellonen,Marika Ruponen,Arto Urtti +20 more
TL;DR: This article aims to provide a systematic and quantitative view on the pharmacokinetic factors in drug delivery to the posterior eye segment, based on the literature and unpublished data from the authors' laboratory.
References
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Book
Applied Regression Analysis
Norman R. Draper,Harry Smith +1 more
TL;DR: In this article, the Straight Line Case is used to fit a straight line by least squares, and the Durbin-Watson Test is used for checking the straight line fit.
Journal ArticleDOI
Potentiometric titrations using Gran plots: A textbook omission
F. J. C. Rossotti,Hazel Rossotti +1 more
TL;DR: Describes Gran's graphical method of end point determination for the precise analysis of acids and bases.
Journal ArticleDOI
Mass transport Phenomena and Models: Theoretical Concepts
Book
Biochemistry of the Eye
TL;DR: Tears, Iris-Ciliary Body, and Trabeculum: Selected Topics in Biochemistry Relevant to the Eye.