Journal ArticleDOI
Correlation between the phenotype and the functional capacity of activated T cells in patients with active systemic lupus erythematosus.
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TLDR
In vitro assays have shown that the different patterns of activation antigens are related to different functional stages of T‐cell activation, and the possible therapeutic consequences are discussed.Abstract:
Activated T cells in the peripheral blood of patients with systemic lupus erythematosus (SLE) were determined using monoclonal antibodies against activation antigens. Elevated percentages of HLA-DR+ T cells were found in association with active disease. In contrast, we observed an increase in IL-2, receptor-bearing T cells in only six out of 16 patients with active disease. In vitro assays, like spontaneous proliferation, response to IL-2, production of IL-2, and immunoglobulin synthesis have shown that the different patterns of activation antigens are related to different functional stages of T-cell activation. The possible therapeutic consequences are discussed.read more
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CD8+ lymphocytes from patients with systemic lupus erythematosus sustain, rather than suppress, spontaneous polyclonal IgG production and synergize with CD4+ cells to support autoantibody synthesis.
TL;DR: Removal of either CD8+ or CD4+ lymphocyte markedly decreased the spontaneous in vitro production of polyclonal IgG and of antigen-specific antibodies by SLE peripheral blood mononuclear cells (PBMC), but both cell subsets were required to reconstitute autoantibody production.
Journal ArticleDOI
Up-regulated expression of Fas antigen (CD95) by peripheral naive and memory T cell subsets in patients with systemic lupus erythematosus (SLE): a possible mechanism for lymphopenia.
Yoshiharu Amasaki,Seiichi Kobayashi,Tsuyoshi Takeda,Nobutaka Ogura,Satoshi Jodo,Tohru Nakabayashi,Akito Tsutsumi,Atsushi Fujisaku,Takao Koike +8 more
TL;DR: The results suggest that T cells with increased Fas antigen expression may be highly susceptible to apoptotic cell death, in vivo, and a putative mechanism for lymphopenia in SLE patients is discussed.
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Quantitative defect of CD4+2H4+ cells in systemic lupus erythematosus and Sjögren's syndrome.
TL;DR: Surface antigens of T lymphocytes in peripheral blood mononuclear cells from 19 patients with systemic lupus erythematosus, 14 patients with Sjögren's syndrome, and 14 healthy control subjects suggest that quantitative defect of suppressor/inducer cells may play an important role in the immunoregulatory disturbance in SLE and SS.
Journal ArticleDOI
Impaired polyclonal T cell cytolytic activity. A possible risk factor for systemic lupus erythematosus.
TL;DR: Impaired generation of polyclonal T cell cytolytic activity may be a predisposing factor in the development of SLE.
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The role of cytokines in the immunopathogenesis of lupus
Barry S. Handwerger,Barry S. Handwerger,Violeta Rus,Ludmila da Silva,Charles S. Via,Charles S. Via +5 more
TL;DR: This review has discussed a number of cytokines which appear to be involved in lupus pathogenesis and the models that have been put forward illustrate several possible mechanisms which may lead to lupu.
References
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Journal Article
Defective production of interleukin 1 and interleukin 2 in patients with systemic lupus erythematosus (SLE).
TL;DR: A severe defect in both IL 1 and IL 2 activity was observed and may be a primary defect that is important in the pathogenesis of systemic lupus erythematosus.
Journal ArticleDOI
The interleukin -2.
TL;DR: The lymphokine interleukin-2, intensively studied during the last years, plays a major role in the regulation of the immune function and is anticipated to have considerable implications in therapy.
Journal Article
Activated T cells in vivo and in vitro: divergence in expression of Tac and Ia antigens in the nonblastoid small T cells of inflammation and normal T cells activated in vitro.
TL;DR: These blastoid cells resembled the small T cells of inflammation in having only very limited overlap between the population that bore Ia antigens and those with the Tac antigen; however, there was a preponderance of Tac-bearing cells.
Journal Article
Characterization of T lymphocyte subpopulations responsible for deficient interleukin 2 activity in patients with systemic lupus erythematosus.
TL;DR: The deficient IL 2 activity may be intrinsic to SLE lymphocytes and may contribute to impaired immunoregulation and to the development of SLE.