Journal ArticleDOI
Critical roles of Raf/MEK/ERK and PI3K/AKT signaling and inactivation of p38 MAP kinase in the differentiation and survival of monocyte-derived immature dendritic cells
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TLDR
The results indicate that the Raf/MEK/ERK and PI3K/AKT signaling pathways play critical roles in the differentiation and survival of immature MoDCs and demonstrates that activated p38 is detrimental to the differentiation of immatureMoDCs.About:
This article is published in Experimental Hematology.The article was published on 2005-05-01. It has received 97 citations till now. The article focuses on the topics: MAPK/ERK pathway & Protein kinase B.read more
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Regulation of dendritic cell development by GM-CSF: molecular control and implications for immune homeostasis and therapy
TL;DR: The specific intracellular events resulting from GM-CSF-induced signaling provide a molecular explanation for GM- CSF-dependent subset distribution as well as clues to the specific characteristics and functions of GM-csF-differentiated DCs compared with DCs generated by fms-related tyrosine kinase 3 ligand.
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Sorafenib, but not sunitinib, affects function of dendritic cells and induction of primary immune responses.
Madeleine M. Hipp,Norbert Hilf,Steffen Walter,Daniela Werth,Katharina M. Brauer,Markus P. Radsak,Toni Weinschenk,Harpreet Singh-Jasuja,Peter Brossart +8 more
TL;DR: Sunitinib, but not sorafenib, application significantly reduced the induction of antigen-specific T cells and numbers of regulatory T cells were reduced in peripheral blood mononuclear cells from mice treated with sunit inib.
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Tumor evasion of the immune system: Inhibiting p38 MAPK signaling restores the function of dendritic cells in multiple myeloma
TL;DR: The results suggested that tumor-induced p38 MAPK activation and ERK inhibition in DCs may be a new mechanism for tumor evasion and that regulating these pathways during DC differentiation provides new strategies for generating potent DC vaccines for immunotherapy in patients with cancer.
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Supernatant from bifidobacterium differentially modulates transduction signaling pathways for biological functions of human dendritic cells.
Cyrille Hoarau,Laurence Martin,Delphine Faugaret,Christophe Baron,Audrey Dauba,Cécile Aubert-Jacquin,Florence Velge-Roussel,Yvon Lebranchu +7 more
TL;DR: For the first time, a fermentation product of a bifidobacteria can differentially activate MAPK, GSK3 and PI3K in order to modulate DC biological functions and give new insights on the fine-tuned balance between the maintenance of normal mucosal homeostasis to commensal and probiotic bacteria and the specific inflammatory immune responses to pathogen bacteria.
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Optimizing immunotherapy in multiple myeloma: restoring the function of patients' monocyte-derived dendritic cells by inhibiting p38 or activating MEK/ERK MAPK and neutralizing interleukin-6 in progenitor cells
Siqing Wang,Sungyoul Hong,Jing Yang,Jianfei Qian,Xiang Zhang,Elizabeth J. Shpall,Larry W. Kwak,Qing Yi +7 more
TL;DR: The mechanistic defects of MoDCs from myeloma patients are delineated and ways for restoring the function of the cells to improve the efficacy of DC-based immunotherapy in this disease are identified.
References
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Journal ArticleDOI
Dendritic cells and the control of immunity
TL;DR: Once a neglected cell type, dendritic cells can now be readily obtained in sufficient quantities to allow molecular and cell biological analysis and the realization that these cells are a powerful tool for manipulating the immune system is realized.
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Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis
TL;DR: The effects of dominant-interfering or constitutively activated forms of various components of the JNK-p38 and ERK signaling pathways demonstrated that activation of JNK and p38 and concurrent inhibition of ERK are critical for induction of apoptosis in these cells.
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Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha.
TL;DR: Cultured DCs are as efficient as antigen-specific B cells in presenting tetanus toxoid (TT) to specific T cell clones and their efficiency of antigen presentation can be further enhanced by specific antibodies via FcR- mediated antigen uptake.
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A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V.
TL;DR: The Annexin V assay offers the possibility of detecting early phases of apoptosis before the loss of cell membrane integrity and permits measurements of the kinetics of apoptotic death in relation to the cell cycle.
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Proliferating dendritic cell progenitors in human blood.
Nikolaus Romani,S Gruner,D. Brang,Eckhart Kämpgen,Angela Lenz,B Trockenbacher,G Konwalinka,Peter O. Fritsch,Ralph M. Steinman,Gerold Schuler +9 more
TL;DR: Large numbers of DC progenitors are observed in cord blood and in adult blood from healthy donors, which should facilitate future studies of their Fc epsilon RI and CD4 receptors, and their use in stimulating T cell-mediated resistance to viruses and tumors.