Journal ArticleDOI
Cubé Resin Insecticide: Identification and Biological Activity of 29 Rotenoid Constituents
Nianbai Fang,John E. Casida +1 more
TLDR
Assays of the 29 rotenoids as inhibitors of NADH:ubiquinone oxidoreductase activity and phorbol ester-induced ornithine decarboxylase activity for cytotoxicity establish similar structure-activity relationships in each system and the importance of the overall molecular conformation and the E-ring substituents.Abstract:
Cube resin, the root extract from Lonchocarpus utilis and urucu, is an important insecticide, acaricide, and piscicide. The four major active ingredients are rotenone, deguelin, rotenolone, and tep...read more
Citations
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Journal ArticleDOI
Natural products in crop protection.
TL;DR: The historical use of natural products in agricultural practices, the impact ofnatural products on the development of new pesticides, and the future prospects for natural products-based pest management are reviewed.
Journal ArticleDOI
Isoflavonoids of the leguminosae
TL;DR: This account describes 275 new isoflavonoids published between 2008 and 2011 as constituents of the Leguminosae, commenting on their source, identification, biological activity, synthesis, and ecological or chemosystematic significance.
Journal ArticleDOI
Biorational insecticides in pest management
TL;DR: A review article of the latest developments of the biorational approaches in pest management appeared in the literature from 1997 to date, paying particular attention to those practical approaches that are respectful to the environment.
Journal ArticleDOI
Rotenone, Deguelin, Their Metabolites, and the Rat Model of Parkinson's Disease
Pierluigi Caboni,Todd B. Sherer,Nanjing Zhang,Georgia Taylor,Hye Me Na,J. Timothy Greenamyre,John E. Casida +6 more
TL;DR: Rotenone was known earlier, and deguelin is shown here to induce a Parkinson's disease (PD)-like syndrome after subcutaneous treatment of rats by osmotic minipump, and is about half as active as rotenone in inducing the PD-like syndrome in rats and in acute ip LD50 in mice.
Journal ArticleDOI
Natural toxins for use in pest management.
Stephen O. Duke,Charles L. Cantrell,Kumudini M. Meepagala,David E. Wedge,Nurhayat Tabanca,Kevin K. Schrader +5 more
TL;DR: There are highly successful products based on natural compounds in the major pesticide classes, including the herbicide glufosinate, the spinosad insecticides, and the strobilurin fungicides, which are discussed.
References
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Journal ArticleDOI
Anticancer action of cubé insecticide: Correlation for rotenoid constituents between inhibition of NADH:ubiquinone oxidoreductase and induced ornithine decarboxylase activities
Nianbai Fang,John E. Casida +1 more
TL;DR: Findings on cubé insecticide constituents and an earlier study comparing rotenone and pyridaben miticide indicate that inhibition of NADH:ubiquinone oxidoreductase activity lowers the level of induced ODC activity leading to the antiproliferative effect and anticancer action.
Journal ArticleDOI
Rotenoids mediate potent cancer chemopreventive activity through transcriptional regulation of ornithine decarboxylase.
Clarissa Gerhäuser,W. Mar,W. Mar,Sang Kook Lee,Nanjoo Suh,Y. Luo,Jerome W. Kosmeder,Lumonadio Luyengi,Harry H. S. Fong,A D Kinghorn,Robert M. Moriarty +10 more
TL;DR: Four active rotenoids obtained from the African plant Mundulea sericea were obtained and appear to function by a unique mechanism at the level of ODC messenger RNA expression, which can be regarded as promising new chemopreventive or anticancer agents.
Journal ArticleDOI
New bioactive flavonoids and stilbenes in cubé resin insecticide
Nianbai Fang,John E. Casida +1 more
TL;DR: Fractionation of cube resin from Lonchocarpus utilus and L. urucu roots led to the isolation and identification of 11 minor flavonoids and stilbenes containing the gem-dimethylpyran moiety or a dihydrodiol derivative thereof as mentioned in this paper.
Journal ArticleDOI
Rotenoids and chalcones from Mundulea sericea that inhibit phorbol ester-induced ornithine decarboxylase activity
TL;DR: In this paper, two new rotenoids, (−)-13α-hydroxydeguelin and (−−13α −13α -hydroxytephrosin, and a new chalcone, munsericin, were isolated from the bark of Mundulea sericea, and their structures were elucidated by spectroscopic methods.
Journal ArticleDOI
Fenazaquin Acaricide Specific Binding Sites in NADH: Ubiquinone Oxidoreductase and Apparently the ATP Synthase Stalk
TL;DR: Fenazaquin (and presumably rotenone as well) therefore has at least two specific binding sites in ETP, the anticipated high–affinity site in NADH:ubiquinone oxidoreductase and apparently a low-affinity sites of unknown function, photoaffinity labeled in the stalk region of ATP synthase.
Related Papers (5)
Anticancer action of cubé insecticide: Correlation for rotenoid constituents between inhibition of NADH:ubiquinone oxidoreductase and induced ornithine decarboxylase activities
Nianbai Fang,John E. Casida +1 more