Cucurbiturils: from synthesis to high-affinity binding and catalysis
Khaleel I. Assaf,Werner M. Nau +1 more
TLDR
The fundamental properties of CBn homologues and their cyclic derivatives are discussed with a focus on their synthesis and their applications in catalysis.Abstract:
In the wide area of supramolecular chemistry, cucurbit[n]urils (CBn) present themselves as a young family of molecular containers, able to form stable complexes with various guests, including drug molecules, amino acids and peptides, saccharides, dyes, hydrocarbons, perfluorinated hydrocarbons, and even high molecular weight guests such as proteins (e.g., human insulin). Since the discovery of the first CBn, CB6, the field has seen tremendous growth with respect to the synthesis of new homologues and derivatives, the discovery of record binding affinities of guest molecules in their hydrophobic cavity, and associated applications ranging from sensing to drug delivery. In this review, we discuss in detail the fundamental properties of CBn homologues and their cyclic derivatives with a focus on their synthesis and their applications in catalysis.read more
Citations
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疟原虫var基因转换速率变化导致抗原变异[英]/Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A
TL;DR: PfPMP1)与感染红细胞、树突状组胞以及胎盘的单个或多个受体作用,在黏附及免疫逃避中起关键的作�ly.
Journal ArticleDOI
Cucurbituril-Based Molecular Recognition.
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Surveying macrocyclic chemistry: from flexible crown ethers to rigid cyclophanes
TL;DR: This Review surveys the recent developments of the chemistry of naturally occurring cyclodextrins, along with a variety of synthetic flexible and rigid macrocycles that have drawn their inspiration from Pedersen's ground-breaking discovery of crown ethers in the mid-1960s.
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Supramolecular chemotherapy based on host–guest molecular recognition: a novel strategy in the battle against cancer with a bright future
Jiong Zhou,Guocan Yu,Feihe Huang +2 more
TL;DR: A review summarizing the progress of supramolecular chemotherapy in cancer treatment based on host-guest recognition and guidance on the design of new targeting supramolescular chemotherapy combining diagnostic and therapeutic functions is presented.
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Drug delivery by supramolecular design
Matthew J. Webber,Robert Langer +1 more
TL;DR: In the context of clinical translation, features of supramolecular design may prove additionally advantageous, specifically in enabling quantitative drug loading, molecularly discrete delivery devices, and a priori knowledge of carrier degradation and clearance mechanisms.
References
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疟原虫var基因转换速率变化导致抗原变异[英]/Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A
TL;DR: PfPMP1)与感染红细胞、树突状组胞以及胎盘的单个或多个受体作用,在黏附及免疫逃避中起关键的作�ly.
Journal ArticleDOI