Current Understandings and Clinical Translation of Nanomedicines for Breast Cancer Therapy.
TLDR
A comprehensive review of the nanomedicines for breast cancer treatment, from laboratory investigations to clinical applications, can be found in this paper, where the authors highlight the key advances in the understanding of the biological fate and the targeting strategies of breast cancer nanometrics and the implications to clinical translation.About:
This article is published in Advanced Drug Delivery Reviews.The article was published on 2021-11-01 and is currently open access. It has received 18 citations till now. The article focuses on the topics: Breast cancer & Medicine.read more
Citations
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Actively Targeted Nanomedicines in Breast Cancer: From Pre-Clinal Investigation to Clinic
TL;DR: All active targeted nanomedicines for the treatment of breast cancer are discussed, analyzing their advantages and disadvantages over conventional chemotherapy as well as the challenges involved in their lab to clinical translation.
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Self-Rectifiable and Hypoxia-Assisted Chemo-Photodynamic Nanoinhibitor for Synergistic Cancer Therapy.
Yanan Wang,J Huo,Shuang Li,Ran Huang,Daopeng Fan,Hanghang Cheng,Bo Wan,Yong-Kun Du,Hua He,Gaiping Zhang +9 more
TL;DR:
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Frontiers in Preparations and Promising Applications of Mesoporous Polydopamine for Cancer Diagnosis and Treatment
Hualin Ma,Jingwen Peng,Jianing Zhang,Li-li Pan,Jiayi Ouyang,Zimu Li,Baochun Guo,Zhen Wang,Ying Ji Xu,Daizheng Lian,Xiaowei Zeng +10 more
TL;DR: In this article , the characteristics and manufacturing process of mesoporous polydopamine (MPDA) are systematically summarized, and the application in the diagnosis and treatment of cancer, and discussed the existing problems in its development and clinical application.
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Nanomedicine in therapeutic warfront against estrogen receptor–positive breast cancer
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Therapeutic potential of non-starch polysaccharides on type 2 diabetes: from hypoglycemic mechanism to clinical trials.
Meng Xiao,Xing Jia,Nifei Wang,Jinho Kang,Xinzhong Hu,H. Douglas Goff,Steve W. Cui,Huihuang Ding,Qingbin Guo +8 more
TL;DR: The development of anti-T2DM medication or dietary supplements of NSPs could be promoted with an in-depth understanding of the multiple regulatory effects in the treatment/intervention of T2DM.
References
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Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries.
Hyuna Sung,Jacques Ferlay,Rebecca L. Siegel,Mathieu Laversanne,Isabelle Soerjomataram,Ahmedin Jemal,Freddie Bray +6 more
TL;DR: The GLOBOCAN 2020 estimates of cancer incidence and mortality produced by the International Agency for Research on Cancer (IARC) as mentioned in this paper show that female breast cancer has surpassed lung cancer as the most commonly diagnosed cancer, with an estimated 2.3 million new cases (11.7%), followed by lung cancer, colorectal (11 4.4%), liver (8.3%), stomach (7.7%) and female breast (6.9%), and cervical cancer (5.6%) cancers.
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Prospective identification of tumorigenic breast cancer cells
Muhammad Al-Hajj,Max S. Wicha,Adalberto Benito-Hernandez,Sean J. Morrison,Sean J. Morrison,Michael F. Clarke +5 more
TL;DR: The ability to prospectively identify tumorigenic cancer cells will facilitate the elucidation of pathways that regulate their growth and survival and strategies designed to target this population may lead to more effective therapies.
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Cancer Statistics, 2021.
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TL;DR: Stem cell biology has come of age: Unequivocal proof that stem cells exist in the haematopoietic system has given way to the prospective isolation of several tissue-specific stem and progenitor cells, the initial delineation of their properties and expressed genetic programmes, and the beginnings of their utility in regenerative medicine.
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Targeting HIF-1 for cancer therapy
TL;DR: Hypoxia-inducible factor 1 (HIF-1) activates the transcription of genes that are involved in crucial aspects of cancer biology, including angiogenesis, cell survival, glucose metabolism and invasion.