Journal ArticleDOI
Cycloheximide Induction of Aflatoxin Synthesis in a Nontoxigenic Strain of Aspergillus Flavus
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TLDR
An inverse correlation is inferred between aflatoxin production and the presence of double–stranded RNA, which has been reported in A. flavus, and cycloheximide has an inhibitory effect on 80S ribosome–directed protein synthesis as well as on double–Stranded RNA virus synthesis in fungi.Abstract:
Cycloheximide Induction of Aflatoxin Synthesis in a Nontoxigenic Strain of Aspergillus Flavusread more
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Patent
Genetic Inhibition by Double-Stranded RNA
Andrew Fire,Stephen A. Kostas,Mary K. Montgomery,Lisa Timmons,SiQun Xu,Hiroaki Tabara,Samuel E. Driver,Craig C. Mello +7 more
TL;DR: In this article, a double-stranded RNA has been used to inhibit gene expression of a target gene in a living cell in order to identify the source and target genes in the cell.
Patent
Methods and means for obtaining modified phenotypes
TL;DR: In this paper, the authors proposed a method to reduce the phenotypic expression of a nucleic acid of interest in eucaryotic cells, particularly in plant cells, by introducing chimeric genes encoding sense and antisense RNA molecules directed towards the target nucleic acids.
Patent
Composition and method for in vivo and in vitro attenuation of gene expression using double stranded rna
TL;DR: The introduction of double stranded RNA into cells, cell culture, organs and tissues, and whole organisms, particularly vertebrates, specifically attenuates gene expression as mentioned in this paper, specifically attenuating gene expression.
Patent
Control of gene expression
M. Graham,Robert Norman Rice +1 more
TL;DR: The present invention utilises recombinant DNA technology to post-transciptionally modify or modulate the expression of a target gene in a cell tissue, organ or whole organism, thereby producing novel phenotypes.
Journal ArticleDOI
Aflatoxin-producing potential of communities of Aspergillus section Flavi from cotton producing areas in the United States
TL;DR: Differences among communities of Aspergillus section Flavi resident in soils planted with cotton were compared among several areas in the southern United States may reflect geographic isolation and/or adaptation, and may cause different vulnerabilities to aflatoxin contamination among crops planted in diverse locations.
References
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Journal Article
Dose-response characteristics of aflatoxin B1 carcinogenesis in the rat.
G N Wogan,P M Newberne +1 more
Journal ArticleDOI
Drugs which affect the Structure and Function of DNA
TL;DR: This article provides a detailed description of three modes of action of antimicrobial drugs that seem to function by combining with DNA, distorting its structure and function.
Journal ArticleDOI
Curing of a Killer Factor in Saccharomyces cerevisiae
Gerald R. Fink,Cora A. Styles +1 more
TL;DR: The segregation patterns of killer strains indicate that this killer determinant may be different from the killer previously described, and treatment of a killer strain with cycloheximide, but not with ethidium bromide, converts it into a sensitive nonkiller.
Book ChapterDOI
The use of inhibitors in studies on protein synthesis.
TL;DR: This chapter summarizes the current knowledge about the mode of action of various inhibitors on pro- and eukaryotic protein synthesis and recommends using appropriate controls when using an antibiotic to ascertain that the inhibitions produced are indeed those which are desired.