Journal ArticleDOI
Cytokines, nitrite/nitrate, soluble tumor necrosis factor receptors, and procalcitonin concentrations : comparisons in patients with septic shock, cardiogenic shock, and bacterial pneumonia
de Werra I,Jaccard C,Corradin Sb,René Chioléro,Bertrand Yersin,Gallati H,Assicot M,Bohuon C,J. D. Baumgartner,Michel P. Glauser,D. Heumann +10 more
TLDR
It was shown that increase of proinflammatory cytokines was a consequence of inflammation, not of shock, and measurements of NO2-/NO3- concentration and procalcitonin concentration represented the most suitable tests for defining patients with septic shock.Abstract:
Objectives To determine and compare the respective concentrations of tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, soluble TNF receptors, nitrite/nitrate (NO2 sup -/NO3 sup -), and procalcitonin in the plasma of patients with septic shock, cardiogenic shock, and bacterial pneumonia withoutread more
Citations
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Serum Procalcitonin and C-Reactive Protein Levels as Markers of Bacterial Infection: A Systematic Review and Meta-analysis
TL;DR: The diagnostic accuracy of PCT markers was higher than that of CRP markers among patients hospitalized for suspected bacterial infections and had a higher positive likelihood ratio and lower negative likelihood ratio than didCRP markers in both groups.
Journal ArticleDOI
Sepsis biomarkers: a review
TL;DR: An electronic search of the PubMed database using the key words "sepsis" and "biomarker" to identify clinical and experimental studies which evaluated a biomarker in sepsis found 3370 references covering 178 different biomarkers.
Journal ArticleDOI
Consensus on circulatory shock and hemodynamic monitoring. Task force of the European Society of Intensive Care Medicine
Maurizio Cecconi,Daniel De Backer,Massimo Antonelli,Richard Beale,Jan Bakker,Christoph Hofer,Roman Jaeschke,Alexandre Mebazaa,Michael R. Pinsky,Jean-Louis Teboul,Jean Louis Vincent,Andrew Rhodes +11 more
TL;DR: In this article, the authors provide support to the bedside clinician regarding the diagnosis, management and monitoring of circulatory shock, which is a life-threatening syndrome resulting in multiorgan failure and a high mortality rate.
Journal ArticleDOI
Diagnostic value of procalcitonin, interleukin-6, and interleukin-8 in critically ill patients admitted with suspected sepsis
Stéphan Juergen Harbarth,Katarina Holeckova,Céline Froidevaux,Didier Pittet,Bara Ricou,Georges E. Grau,Laszlo Vadas,Jérôme Pugin +7 more
TL;DR: Elevated PCT concentrations appear to be a promising indicator of sepsis in newly admitted, critically ill patients capable of complementing clinical signs and routine laboratory parameters suggestive of severe infection.
Journal ArticleDOI
Procalcitonin as a diagnostic test for sepsis in critically ill adults and after surgery or trauma: a systematic review and meta-analysis.
TL;DR: Procalcitonin represents a good biological diagnostic marker for sepsis, severe sepsi, or septic shock, difficult diagnoses in critically ill patients and should be included in diagnostic guidelines for sePSis and in clinical practice in intensive care units.
References
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Journal ArticleDOI
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Pierre Damas,Didier Ledoux,Monique Nys,Y Vrindts,Donat De Groote,Paul Franchimont,Maurice Lamy +6 more
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Journal ArticleDOI
Circulating Interleukin-1 and Tumor Necrosis Factor in Septic Shock and Experimental Endotoxin Fever
Joseph G. Cannon,Ronald G. Tompkins,Jeffrey A. Gelfand,H.R. Michie,G.G. Stanford,J.W.M. van der Meer,Stefan Endres,Gerhard Lonnemann,J. Corsetti,B. Chernow,Douglas W. Wilmore,Sheldon M. Wolff,John F. Burke,Charles A. Dinarello +13 more
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