Decoding the Role of the Insula in Human Cognition: Functional Parcellation and Large-Scale Reverse Inference
TLDR
The present study suggests that the insula is instrumental in integrating disparate functional systems involved in processing affect, sensory-motor processing, and general cognition and is well suited to provide an interface between feelings, cognition, and action.Abstract:
Recent work has indicated that the insula may be involved in goal-directed cognition, switching between networks, and the conscious awareness of affect and somatosensation. However, these findings have been limited by the insula's remarkably high base rate of activation and considerable functional heterogeneity. The present study used a relatively unbiased data-driven approach combining resting-state connectivity-based parcellation of the insula with large-scale meta-analysis to understand how the insula is anatomically organized based on functional connectivity patterns as well as the consistency and specificity of the associated cognitive functions. Our findings support a tripartite subdivision of the insula and reveal that the patterns of functional connectivity in the resting-state analysis appear to be relatively conserved across tasks in the meta-analytic coactivation analysis. The function of the networks was meta-analytically "decoded" using the Neurosynth framework and revealed that while the dorsoanterior insula is more consistently involved in human cognition than ventroanterior and posterior networks, each parcellated network is specifically associated with a distinct function. Collectively, this work suggests that the insula is instrumental in integrating disparate functional systems involved in processing affect, sensory-motor processing, and general cognition and is well suited to provide an interface between feelings, cognition, and action.read more
Citations
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TL;DR: A connectivity-based parcellation framework is designed that identifies the subdivisions of the entire human brain, revealing the in vivo connectivity architecture and provides a fine-grained, cross-validated atlas and contains information on both anatomical and functional connections.
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Jason T. Buhle,Jennifer A. Silvers,Tor D. Wager,Richard B. Lopez,Chukwudi Onyemekwu,Hedy Kober,Jochen Weber,Kevin N. Ochsner +7 more
TL;DR: A meta-analysis of 48 neuroimaging studies of reappraisal suggests that reappRAisal involves the use of cognitive control to modulate semantic representations of an emotional stimulus, and these altered representations in turn attenuate activity in the amygdala.
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Network attributes for segregation and integration in the human brain.
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Structure and Function of the Human Insula.
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