Depth-encoded all-fiber swept source polarization sensitive OCT
Zhao Wang,Hsiang-Chieh Lee,Osman O. Ahsen,ByungKun Lee,WooJhon Choi,Benjamin Potsaid,Jonathan J. Liu,Vijaysekhar Jayaraman,A. Cable,Martin F. Kraus,Kaicheng Liang,Joachim Hornegger,James G. Fujimoto +12 more
TLDR
A simple and robust all-fiber PS-OCT system based on swept source technology and polarization depth-encoding that was demonstrated in human retina, finger and lip imaging, as well as ex vivo swine esophagus and cardiovascular imaging.Abstract:
Polarization sensitive optical coherence tomography (PS-OCT) is a functional extension of conventional OCT and can assess depth-resolved tissue birefringence in addition to intensity. Most existing PS-OCT systems are relatively complex and their clinical translation remains difficult. We present a simple and robust all-fiber PS-OCT system based on swept source technology and polarization depth-encoding. Polarization multiplexing was achieved using a polarization maintaining fiber. Polarization sensitive signals were detected using fiber based polarization beam splitters and polarization controllers were used to remove the polarization ambiguity. A simplified post-processing algorithm was proposed for speckle noise reduction relaxing the demand for phase stability. We demonstrated systems design for both ophthalmic and catheter-based PS-OCT. For ophthalmic imaging, we used an optical clock frequency doubling method to extend the imaging range of a commercially available short cavity light source to improve polarization depth-encoding. For catheter based imaging, we demonstrated 200 kHz PS-OCT imaging using a MEMS-tunable vertical cavity surface emitting laser (VCSEL) and a high speed micromotor imaging catheter. The system was demonstrated in human retina, finger and lip imaging, as well as ex vivo swine esophagus and cardiovascular imaging. The all-fiber PS-OCT is easier to implement and maintain compared to previous PS-OCT systems and can be more easily translated to clinical applications due to its robust design.read more
Citations
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Journal Article
In Vivo Endoscopic Optical Biopsy with Optical Coherence Tomography
Guillermo J. Tearney,Mark E. Brezinski,Brett E. Bouma,Stephen A. Boppart,Costas Pitris,James F. Southern,James G. Fujimoto +6 more
TL;DR: In this article, optical coherence tomography was adapted to allow high-speed visualization of tissue in a living animal with a catheter-endoscope 1 millimeter in diameter, which was used to obtain cross-sectional images of the rabbit gastrointestinal and respiratory tracts at 10-micrometer resolution.
Journal Article
Polarization-sensitive low-coherence reflectometer for birefringence characterization and ranging
TL;DR: In this article, a polarization-sensitive optical coherence-domain reflectometer capable of characterizing the phase retardation between orthogonal linear polarization modes at each reflection point in a birefringent sample is presented.
Journal ArticleDOI
Polarization sensitive optical coherence tomography – a review [Invited]
TL;DR: Polarization sensitive (PS) OCT draws advantage from the fact that several materials and tissues can change the light's polarization state, adding an additional contrast channel and providing quantitative information.
Journal ArticleDOI
Deep tissue volume imaging of birefringence through fibre-optic needle probes for the delineation of breast tumour
Martin Villiger,Dirk Lorenser,Robert A. McLaughlin,Bryden C. Quirk,Rodney W. Kirk,Brett E. Bouma,Brett E. Bouma,David D. Sampson +7 more
TL;DR: In this paper, the authors performed polarization-sensitive optical coherence tomography through miniature imaging needles and developed an algorithm to efficiently reconstruct images of the depth-resolved tissue birefringence free of artefacts.
Patent
Integrated optical system and components utilizing tunable optical sources and coherent detection and phased array for imaging, ranging, sensing, communications and other applications
TL;DR: In this article, an integrated optical system is configured such that when the optical source is tuned in optical frequency, the receiver produces electrical signals that are processed to produce optical profile information about the sample.
References
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Optical coherence tomography
David Huang,Eric A. Swanson,Charles P. Lin,Joel S. Schuman,William G. Stinson,Warren Chang,Michael R. Hee,Thomas J. Flotte,Kenton W. Gregory,Carmen A. Puliafito,James G. Fujimoto +10 more
TL;DR: OCT as discussed by the authors uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way analogous to ultrasonic pulse-echo imaging.
Book ChapterDOI
Optical Coherence Tomography
Eric A. Swanson,J. Izatt,M. Bee,David Huang,Charles P. Lin,Carmen A. Puliafito,Carmen A. Puliafito,James G. Fujimoto +7 more
TL;DR: Optical coherence tomography (OCT) has developed rapidly since its first realisation in medicine and is currently an emerging technology in the diagnosis of skin disease as mentioned in this paper, where OCT is an interferometric technique that detects reflected and backscattered light from tissue.
Journal ArticleDOI
Split-spectrum amplitude-decorrelation angiography with optical coherence tomography
Yali Jia,Ou Tan,Jason Tokayer,Benjamin Potsaid,Y. Wang,Jonathan J. Liu,Martin F. Kraus,Hrebesh M. Subhash,James G. Fujimoto,Joachim Hornegger,David Huang +10 more
TL;DR: In this paper, a split-spectrum amplitude-decorrelation angiography (SSADA) was proposed to improve the signal-to-noise ratio (SNR) of flow detection.
Journal ArticleDOI
In Vivo Endoscopic Optical Biopsy with Optical Coherence Tomography
Guillermo J. Tearney,Mark E. Brezinski,Mark E. Brezinski,Brett E. Bouma,Brett E. Bouma,Stephen A. Boppart,Stephen A. Boppart,Costas Pitris,Costas Pitris,James F. Southern,James F. Southern,James G. Fujimoto,James G. Fujimoto +12 more
TL;DR: Optical coherence tomography was adapted to allow high-speed visualization of tissue in a living animal with a catheter-endoscope 1 millimeter in diameter, and was used to obtain cross-sectional images of the rabbit gastrointestinal and respiratory tracts at 10-micrometer resolution.
Journal Article
In Vivo Endoscopic Optical Biopsy with Optical Coherence Tomography
Guillermo J. Tearney,Mark E. Brezinski,Brett E. Bouma,Stephen A. Boppart,Costas Pitris,James F. Southern,James G. Fujimoto +6 more
TL;DR: In this article, optical coherence tomography was adapted to allow high-speed visualization of tissue in a living animal with a catheter-endoscope 1 millimeter in diameter, which was used to obtain cross-sectional images of the rabbit gastrointestinal and respiratory tracts at 10-micrometer resolution.