Journal ArticleDOI
Designing of a multi-epitope vaccine candidate against Nipah virus by in silico approach: a putative prophylactic solution for the deadly virus
TLDR
A stable multivalent vaccine combining several T-cell and B-cell epitopes of the essential Nipah viral proteins with the help of different ligands and adjuvants which can effectively induce both humoral and cellular immune responses in human is designed.Abstract:
Nipah virus (NPV) is one of the most notorious viruses with a very high fatality rate. Because of the recurrent advent of this virus and its severe neurological implications, often leading to high ...read more
Citations
More filters
Journal ArticleDOI
Immunoinformatics Approach to Design Multi-Epitope- Subunit Vaccine against Bovine Ephemeral Fever Disease
TL;DR: In this paper, a highly efficacious multi-epitope vaccine candidate was designed against the geographically distributed bovine ephemeral fever virus (BEFV) population.
Journal ArticleDOI
Mining of Ebola virus genome for the construction of multi-epitope vaccine to combat its infection.
TL;DR: Ebola virus is the primary causative agent of viral hemorrhagic fever that is an epidemic disease and responsible for the massive premature deaths in humans as mentioned in this paper, despite knowing the molecular mechanism.
Journal ArticleDOI
Scrutinizing the SARS-CoV-2 protein information for designing an effective vaccine encompassing both the T-cell and B-cell epitopes.
TL;DR: This present study provides an initial platform for the rapid generation of an efficacious protective vaccine for combating COVID-19 and reveals the plausibility of the high expression and easy purification of the vaccine product.
Journal ArticleDOI
In silico vaccine design: A tutorial in immunoinformatics
TL;DR: In this paper , the basic procedure for in silico vaccine design is outlined, and three concise phases are discussed: target selection and epitope identification, vaccine construction, and vaccine analysis and refinement.
Posted ContentDOI
Scrutinizing the SARS-CoV-2 protein information for the designing an effective vaccine encompassing both the T-cell and B-cell epitopes
TL;DR: This present study provides an initial platform of the rapid generation of an efficacious protective vaccine for combating COVID-19 and shows the plausibility of the high expression and easy purification of the vaccine product.
References
More filters
Journal ArticleDOI
PROCHECK: a program to check the stereochemical quality of protein structures
TL;DR: The PROCHECK suite of programs as mentioned in this paper provides a detailed check on the stereochemistry of a protein structure and provides an assessment of the overall quality of the structure as compared with well refined structures of the same resolution.
Journal ArticleDOI
Scalable molecular dynamics with NAMD
James C. Phillips,Rosemary Braun,Wei Wang,James C. Gumbart,Emad Tajkhorshid,Elizabeth Villa,Christophe Chipot,Robert D. Skeel,Laxmikant V. Kale,Klaus Schulten +9 more
TL;DR: NAMD as discussed by the authors is a parallel molecular dynamics code designed for high-performance simulation of large biomolecular systems that scales to hundreds of processors on high-end parallel platforms, as well as tens of processors in low-cost commodity clusters, and also runs on individual desktop and laptop computers.
Book ChapterDOI
Protein identification and analysis tools in the ExPASy server
Marc R. Wilkins,Elisabeth Gasteiger,Amos Marc Bairoch,Jean Emmanuel Sanchez,Keith L. Williams,Ron D. Appel,Denis Hochstrasser +6 more
TL;DR: Details are given about protein identification and analysis software that is available through the ExPASy World Wide Web server and the extensive annotation available in the Swiss-Prot database is used.
Journal ArticleDOI
The I-TASSER Suite: protein structure and function prediction
TL;DR: A stand-alone I-TASSER Suite that can be used for off-line protein structure and function prediction and three complementary algorithms to enhance function inferences are developed, the consensus of which is derived by COACH4 using support vector machines.