Detection of catalase in rat heart mitochondria.
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TLDR
Catalase, representing 0.025% of heart mitochondrial protein, is important for detoxifying mitochondrial derived H2O2 and represents a key antioxidant defense mechanism for myocardial tissue.About:
This article is published in Journal of Biological Chemistry.The article was published on 1991-11-15 and is currently open access. It has received 522 citations till now. The article focuses on the topics: Catalase & Mitochondrion.read more
Citations
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Journal ArticleDOI
How mitochondria produce reactive oxygen species.
TL;DR: The description outlined here facilitates the understanding of factors that favour mitochondrial ROS production and develops better methods to measure mitochondrial O2•− and H2O2 formation in vivo, as uncertainty about these values hampers studies on the role of mitochondrial ROS in pathological oxidative damage and redox signalling.
Journal ArticleDOI
Mitochondrial formation of reactive oxygen species.
TL;DR: This review describes the main mitochondrial sources of reactive species and the antioxidant defences that evolved to prevent oxidative damage in all the mitochondrial compartments and discusses various physiological and pathological scenarios resulting from an increased steady state concentration of mitochondrial oxidants.
Journal ArticleDOI
Mitochondria, Oxidants, and Aging
TL;DR: The evidence is reviewed that both supports and conflicts with the free radical theory of aging and the growing link between mitochondrial metabolism, oxidant formation, and the biology of aging is examined.
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Mitochondrial free radical generation, oxidative stress, and aging.
TL;DR: In this article, the authors reviewed the mitochondrial rates of production and steady state levels of reactive oxygen species generated by mitochondria, or from other sites within or outside the cell, cause damage to mitochondrial components and initiate degradative processes.
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First line defence antioxidants-superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPX): Their fundamental role in the entire antioxidant defence grid
TL;DR: The present review tends to articulate important information on SOD, CAT and GPX as first line defense antioxidant enzymes.
References
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Journal ArticleDOI
Hydroperoxide metabolism in mammalian organs.
Book
Data for Biochemical Research
TL;DR: Methods for the detection of biochemical compounds on paper and thin layer chromatograms, with some notes on separation Ion exchange, gel filtration, and affinity chromatography media isotopic data.
Journal Article
Biology of disease: free radicals and tissue injury.
Bruce A. Freeman,James D. Crapo +1 more
TL;DR: This review surveys cellular sources of free radicals and the reactions they can undergo and discusses cellular defenses and adaptive mechanisms.
Journal ArticleDOI
Generation of superoxide anion by the NADH dehydrogenase of bovine heart mitochondria.
J F Turrens,A Boveris +1 more
TL;DR: An O2- -dependent autocatalytic process that requires NADH, submitochondrial particles and adrenaline is described.
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Nondroplet ultrastructural demonstration of cytochrome oxidase activity with a polymerizing osmiophilic reagent, diaminobenzidine (dab)
TL;DR: The sites of reactivity of both parts of the respiratory chain have implications for the chemiosomotic hypothesis of Mitchell who suggests a mechanism of energy conservation during electron transport in the respiratory Chain of the mitochondrion.