Journal ArticleDOI
Dietary flavonoid aglycones and their glycosides: Which show better biological significance?
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TLDR
With in vivo (oral) treatment, flavonoids glycosides showed similar or even higher antidiabetes, anti-inflammatory, antidegranulating, antistress, and antiallergic activity than their flavonoid aglycones.Abstract:
The dietary flavonoids, especially their glycosides, are the most vital phytochemicals in diets and are of great general interest due to their diverse bioactivity. The natural flavonoids almost all exist as their O-glycoside or C-glycoside forms in plants. In this review, we summarized the existing knowledge on the different biological benefits and pharmacokinetic behaviors between flavonoid aglycones and their glycosides. Due to various conclusions from different flavonoid types and health/disease conditions, it is very difficult to draw general or universally applicable comments regarding the impact of glycosylation on the biological benefits of flavonoids. It seems as though O-glycosylation generally reduces the bioactivity of these compounds - this has been observed for diverse properties including antioxidant activity, antidiabetes activity, anti-inflammation activity, antibacterial, antifungal activity, antitumor activity, anticoagulant activity, antiplatelet activity, antidegranulating activity, antitrypanosomal activity, influenza virus neuraminidase inhibition, aldehyde oxidase inhibition, immunomodulatory, and antitubercular activity. However, O-glycosylation can enhance certain types of biological benefits including anti-HIV activity, tyrosinase inhibition, antirotavirus activity, antistress activity, antiobesity activity, anticholinesterase potential, antiadipogenic activity, and antiallergic activity. However, there is a lack of data for most flavonoids, and their structures vary widely. There is also a profound lack of data on the impact of C-glycosylation on flavonoid biological benefits, although it has been demonstrated that in at least some cases C-glycosylation has positive effects on properties that may be useful in human healthcare such as antioxidant and antidiabetes activity. Furthermore, there is a lack of in vivo data that would make it possible to make broad generalizations concerning the influence of glycosylation on the benefits of flavonoids for human health. It is possible that the effects of glycosylation on flavonoid bioactivity in vitro may differ from that seen in vivo. With in vivo (oral) treatment, flavonoid glycosides showed similar or even higher antidiabetes, anti-inflammatory, antidegranulating, antistress, and antiallergic activity than their flavonoid aglycones. Flavonoid glycosides keep higher plasma levels and have a longer mean residence time than those of aglycones. We should pay more attention to in vivo benefits of flavonoid glycosides, especially C-glycosides.read more
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The neuromodulatory effects of flavonoids and gut Microbiota through the gut-brain axis
TL;DR: A review of the relationship between bioactive flavonoids and the gut-brain axis is presented in this article , which examines the current state-of-the-art research into the relationship.
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Beneficial Effects of Bauhinia rufa Leaves on Oxidative Stress, Prevention, and Treatment of Obesity in High-Fat Diet-Fed C57BL/6 Mice
Paola dos Santos da Rocha,Sarah Lam Orué,Daniel Ferreira Leite,Priscilla Pereira de Toledo Espindola,Nadla S. Cassemiro,Denise Brentan Silva,Carlos Alexandre Carollo,Valéria Nunes-Souza,Luiza A. Rabelo,Jaqueline Ferreira Campos,Leticia M. Estevinho,Edson Lucas dos Santos,Kely de Picoli Souza +12 more
TL;DR: In this article , Bauhinia rufa (Bong.) Steud leaves (MEBr) were investigated for the treatment of obesity in mice fed a high-fat diet (HFD 60%).
Journal ArticleDOI
In vitro acetylcholinesterase, tyrosinase inhibitory potentials of secondary metabolites from Euphorbia schimperiana and Euphorbia balsamifera
Salha Mana Aljubiri,Eman Abd Elsalam,Faten K. Abd El Hady,Mohamed O. Radwan,Abdulrahman I. Almansour,Kamel H. Shaker +5 more
TL;DR: In this paper , the AChE, tyrosinase, and α-glucosidase inhibition activities of Euphorbia schimperiana and E. balsamifera extracts, fractions, and available pure compounds were evaluated.
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Can floral nectars reduce transmission of Leishmania?
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The Synthesis, Characterization and Anti-Tumor Activity of a Cu-MOF Based on Flavone-6,2′-dicarboxylic Acid
Jie Zhang,Tingting Jiang,Xinyu Song,Qingling Li,Yang Liu,Yan-hui Wang,Xiaojv Chi,Jie Sun,Liangliang Zhang +8 more
TL;DR: A two-dimensional copper(II) framework (LDU-1) was constructed under solvothermal conditions and characterized by single-crystal X-ray diffraction, infrared spectroscopy (IR), thermogravimetric analysis and powder X-Ray diffraction (PXRD) as discussed by the authors.
References
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Journal ArticleDOI
Structure-antioxidant activity relationships of flavonoids and phenolic acids
TL;DR: The factors underlying the influence of the different classes of polyphenols in enhancing their resistance to oxidation are discussed and support the contention that the partition coefficients of the flavonoids as well as their rates of reaction with the relevant radicals define the antioxidant activities in the lipophilic phase.
Journal ArticleDOI
Biochemistry and molecular cell biology of diabetic complications
TL;DR: This integrating paradigm provides a new conceptual framework for future research and drug discovery in diabetes-specific microvascular disease and seems to reflect a single hyperglycaemia-induced process of overproduction of superoxide by the mitochondrial electron-transport chain.
Journal ArticleDOI
Antioxidant and antiradical activities of flavonoids.
Stanisław Burda,Wieslaw Oleszek +1 more
TL;DR: From seven structurally divergent groups of flavonoids, only flavonols with a free hydroxyl group at the C-3 position of the flavonoid skeleton showed high inhibitory activity to beta-carotene oxidation.
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A review on the dietary flavonoid kaempferol.
José Manuel Calderón-Montaño,Estefanía Burgos-Morón,Concepción Pérez-Guerrero,Miguel López-Lázaro +3 more
TL;DR: The distribution of ka Kempferol in the plant kingdom and its pharmacological properties are reviewed and the pharmacokinetics and safety of kaempferol are analyzed to help understand the health benefits of kaEMPferol-containing plants and to develop this flavonoid as a possible agent for the prevention and treatment of some diseases.
Journal ArticleDOI
Recent advances in understanding the antibacterial properties of flavonoids
T.P. Tim Cushnie,Andrew J. Lamb +1 more
TL;DR: Flavonoids are a family of plant-derived compounds with potentially exploitable activities, including direct antibacterial activity, synergism with antibiotics, and suppression of bacterial virulence, and recent advances towards understanding these properties are described.