Journal ArticleDOI
Dietary flavonoid aglycones and their glycosides: Which show better biological significance?
Reads0
Chats0
TLDR
With in vivo (oral) treatment, flavonoids glycosides showed similar or even higher antidiabetes, anti-inflammatory, antidegranulating, antistress, and antiallergic activity than their flavonoid aglycones.Abstract:
The dietary flavonoids, especially their glycosides, are the most vital phytochemicals in diets and are of great general interest due to their diverse bioactivity. The natural flavonoids almost all exist as their O-glycoside or C-glycoside forms in plants. In this review, we summarized the existing knowledge on the different biological benefits and pharmacokinetic behaviors between flavonoid aglycones and their glycosides. Due to various conclusions from different flavonoid types and health/disease conditions, it is very difficult to draw general or universally applicable comments regarding the impact of glycosylation on the biological benefits of flavonoids. It seems as though O-glycosylation generally reduces the bioactivity of these compounds - this has been observed for diverse properties including antioxidant activity, antidiabetes activity, anti-inflammation activity, antibacterial, antifungal activity, antitumor activity, anticoagulant activity, antiplatelet activity, antidegranulating activity, antitrypanosomal activity, influenza virus neuraminidase inhibition, aldehyde oxidase inhibition, immunomodulatory, and antitubercular activity. However, O-glycosylation can enhance certain types of biological benefits including anti-HIV activity, tyrosinase inhibition, antirotavirus activity, antistress activity, antiobesity activity, anticholinesterase potential, antiadipogenic activity, and antiallergic activity. However, there is a lack of data for most flavonoids, and their structures vary widely. There is also a profound lack of data on the impact of C-glycosylation on flavonoid biological benefits, although it has been demonstrated that in at least some cases C-glycosylation has positive effects on properties that may be useful in human healthcare such as antioxidant and antidiabetes activity. Furthermore, there is a lack of in vivo data that would make it possible to make broad generalizations concerning the influence of glycosylation on the benefits of flavonoids for human health. It is possible that the effects of glycosylation on flavonoid bioactivity in vitro may differ from that seen in vivo. With in vivo (oral) treatment, flavonoid glycosides showed similar or even higher antidiabetes, anti-inflammatory, antidegranulating, antistress, and antiallergic activity than their flavonoid aglycones. Flavonoid glycosides keep higher plasma levels and have a longer mean residence time than those of aglycones. We should pay more attention to in vivo benefits of flavonoid glycosides, especially C-glycosides.read more
Citations
More filters
Book ChapterDOI
Use of Selected Antioxidant-Rich Spices and Herbs in Foods
Percin Karakol,Emin Kapi +1 more
TL;DR: In this article, the antioxidant properties of various herbs and spices used to add flavor to foods or to extend their shelf life have been examined in the light of large-scale nutritional epidemiological studies, in vitro cellular/animal studies and clinical trials.
Journal ArticleDOI
Antilipidemic and Hepatoprotective Effects of Ethanol Extract of Justicia spicigera in Streptozotocin Diabetic Rats
Marina Murillo-Villicaña,Ruth Noriega-Cisneros,Donovan J. Peña-Montes,Maribel Huerta-Cervantes,Asdrúbal Aguilera-Méndez,Christian Cortés-Rojo,Rafael Salgado-Garciglia,Rocío Montoya-Pérez,Héctor Riveros-Rosas,Alfredo Saavedra-Molina +9 more
TL;DR: In this paper , Justicia spicigera (EJS) ethanol extract was applied to male Wistar rats with streptozotocin-induced diabetes to maintain diminished lipid and liver function profiles.
Journal ArticleDOI
Computational study of the main flavonoids from Chrysobalanus icaco L. against NADPH-oxidase and in vitro Antioxidant Activity
Lucas Villar Pedrosa da Silva Pantoja,Surianne Samantha Amorim Trindade,A. S. Carneiro,João Paulo Bastos Silva,Thiago Portal da Paixão,Camila Fernanda Rodrigues Romeiro,Cleiane Santana Pinheiro de Moraes,Ana Carla Godinho Pinto,Nádia Rezende Barbosa Raposo,Marcieni Ataíde de Andrade +9 more
TL;DR: The results demonstrate for the first time the in silico action of quercetin against NOX, as well as reiterate the antioxidant potential of C. icaco.
Journal ArticleDOI
Insight into isolation and characterization of compounds of Chaerophyllum bulbosum aerial part with antioxidant, anticholinesterase, anti-urease, anti-tyrosinase, and anti-diabetic activities
TL;DR: In this article, various extracts of Chaerophyllum bulbosum L. aerial parts were investigated in terms of the isolation of compounds and ability to inhibit enzyme (AChE, BChE urease, tyrosinase, α-amylase, and α-glucosidase) activities.
Journal ArticleDOI
Characterization of Constituents with Potential Anti-Inflammatory Activity in Chinese Lonicera Species by UHPLC-HRMS Based Metabolite Profiling
Eva M. Pferschy-Wenzig,Sabine Ortmann,Atanas G. Atanasov,Klara Hellauer,Jürgen Hartler,Olaf Kunert,Markus Gold-Binder,Angela Ladurner,Elke H. Heiss,Simone Latkolik,Yimin Zhao,Pia Raab,Marlene Monschein,Nina Trummer,Bolaji Oloyede Samuel,Sara L. Crockett,Jianhua Miao,Gerhard G. Thallinger,Valery N. Bochkov,Verena M. Dirsch,Rudolf Bauer +20 more
TL;DR: Overall, the approach was found useful to narrow down the number of potentially bioactive constituents in the complex extracts investigated, and the application of more refined concepts, such as extract prefractionation combined with bio-chemometrics, may help to further enhance the reliability of candidate selection.
References
More filters
Journal ArticleDOI
Structure-antioxidant activity relationships of flavonoids and phenolic acids
TL;DR: The factors underlying the influence of the different classes of polyphenols in enhancing their resistance to oxidation are discussed and support the contention that the partition coefficients of the flavonoids as well as their rates of reaction with the relevant radicals define the antioxidant activities in the lipophilic phase.
Journal ArticleDOI
Biochemistry and molecular cell biology of diabetic complications
TL;DR: This integrating paradigm provides a new conceptual framework for future research and drug discovery in diabetes-specific microvascular disease and seems to reflect a single hyperglycaemia-induced process of overproduction of superoxide by the mitochondrial electron-transport chain.
Journal ArticleDOI
Antioxidant and antiradical activities of flavonoids.
Stanisław Burda,Wieslaw Oleszek +1 more
TL;DR: From seven structurally divergent groups of flavonoids, only flavonols with a free hydroxyl group at the C-3 position of the flavonoid skeleton showed high inhibitory activity to beta-carotene oxidation.
Journal ArticleDOI
A review on the dietary flavonoid kaempferol.
José Manuel Calderón-Montaño,Estefanía Burgos-Morón,Concepción Pérez-Guerrero,Miguel López-Lázaro +3 more
TL;DR: The distribution of ka Kempferol in the plant kingdom and its pharmacological properties are reviewed and the pharmacokinetics and safety of kaempferol are analyzed to help understand the health benefits of kaEMPferol-containing plants and to develop this flavonoid as a possible agent for the prevention and treatment of some diseases.
Journal ArticleDOI
Recent advances in understanding the antibacterial properties of flavonoids
T.P. Tim Cushnie,Andrew J. Lamb +1 more
TL;DR: Flavonoids are a family of plant-derived compounds with potentially exploitable activities, including direct antibacterial activity, synergism with antibiotics, and suppression of bacterial virulence, and recent advances towards understanding these properties are described.